Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice

Fan, Xingpei; Wei, Xiangjuan; Hu, Hailong; Zhang, Boya; Yang, Daqian; Du, Hai-Ning; Zhu, Ruijiao; Sun, Xiaotong; Oh, Yuri; Gu, Ning

doi:10.1016/j.chemosphere.2021.132607

Cited by 84 publications

(35 citation statements)

References 40 publications

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“…Males exposed to small MP (T2) had higher cholesterol levels than control males (Figure A1; χ 3 = 8.80, P = 0.03; post hoc P = 0.05). These elevated levels of cholesterol are in agreement with the shearwaters study and could be indicative of metabolic disruption driven by MP or be related to exposure to plastic-associated chemicals . Females exposed to the mixture of large and small MP (T3) tended to have lower cholesterol levels than control females (Figure A1; F 3 = 5.64, P < 0.01; post hoc P = 0.09).…”

Section: Resultssupporting

confidence: 85%

Microplastic Ingestion Induces Size-Specific Effects in Japanese Quail

Monclús

Smith

Ciesielski

et al. 2022

Environ. Sci. Technol.

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Plastic pollution can pose a threat to birds. Yet, little is known about the sublethal effects of ingested microplastics (MP), and the effects of MP < 1 mm in birds remain unknown. This study therefore aimed at evaluating the toxicity of environmentally relevant polypropylene and polyethylene particles collected in the Norwegian coast in growing Japanese quail (Coturnix japonica). Birds were orally exposed to 600 mg MP over 5 weeks, covering small (<125 μm) and large (3 mm) MP, both separately and in a mixture. We evaluated multiple sublethal endpoints in quail, including oxidative stress, cytokine levels, blood-biochemical parameters, and reproductive hormones in blood, as well as body mass. Exposure to small MP significantly induced the activities of the antioxidant enzymes catalase, glutathione-S-transferase, and glutathione peroxidase. Exposure to large MP increased the levels of aspartate aminotransferase (liver parameter) and decreased 17β-estradiol levels in females. Body mass was not directly affected by MP ingestion; however, quail exposed to small MP and a mixture of large and small MP had a different growth rate compared to control quail. Our study used similar levels of MP as ingested by wild birds and demonstrated size-dependent effects of MP that can result in sublethal effects in avifauna.

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Section: Resultssupporting

confidence: 85%

Microplastic Ingestion Induces Size-Specific Effects in Japanese Quail

Monclús

Smith

Ciesielski

et al. 2022

Environ. Sci. Technol.

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“…Chronic exposure to monodispersed polystyrene significantly increases plasma glucose levels and ROS levels but does not influence plasma insulin secretion. Ultimately oral administration of monodispersed polystyrene increases ROS, liver triglycerides and determines the accumulation of cholesterol in mice [53]. A schematic summary of the various effects consequent from microplastic presence in mice offspring is illustrated in Fig.…”

Section: Disease Mechanism and Cellular Damagementioning

confidence: 99%

Pregnancy in the Era of the Environmental Crisis: Plastic and Pollution

Ragusa¹,

Principi²,

Matta³

2022

Clin. Exp. Obstet. Gynecol.

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Objective:The environmental crisis we are experiencing is becoming a more popular topic of expert discussion and analysis. Human activity and expansion on the planet are exacerbating climate change and global warming, this, together with the increase in plastic production, and general pollution, posing a threat to our resources, supplies, and survival. This research aims to review what is known about the association between pollution and pregnancy and sensitize experts to women's education towards healthier behaviors. Mechanism: We chose to focus on the effects of the environment on fetal development and maternal health, considering various studies that highlight the potential consequences of exposure to certain environmental stressors. The paper briefly illustrates the probable mechanisms that, starting from cellular and intracellular damage, determined above all by plastics, lead to chronic activation of the immune system in response to danger and, therefore, to epigenetic modifications at the base of diseases in adulthood. Findings in Brief: We describe the effects of the main pollutants on pregnancy, with particular attention to the role of plastic. Finally, we briefly outline some individual possible solutions to this complex problem. Conclusions: In the era of environmental crisis, becoming aware of the mechanisms behind biological damage resulting from exposure to certain pollutants and plastics, especially in a period as sensitive as pregnancy, should be the driving force behind a change of direction. As physicians, this means educating our patients and recommending individual solutions to reduce the impact of contaminants to provide the best possible environment for women's and children's health, especially during the delicate period of pregnancy; but the ultimate solution is to drastically reduce global plastic production and pollution, and to recycle the plastic that is needed anyway.

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“…Chronic exposure to monodispersed polystyrene significantly increases plasma glucose levels and ROS levels but does not influence plasma insulin secretion. Ultimately, oral administration of monodispersed polystyrene increases ROS, liver triglycerides and determines the accumulation of cholesterol in mice [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas

Ragusa

Matta

Cristiano

et al. 2022

IJERPH

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Microplastics (MPs) are defined as plastic particles smaller than 5 mm. They have been found almost everywhere they have been searched for and recent discoveries have also demonstrated their presence in human placenta, blood, meconium, and breastmilk, but their location and toxicity to humans have not been reported to date. The aim of this study was twofold: 1. To locate MPs within the intra/extracellular compartment in human placenta. 2. To understand whether their presence and location are associated with possible structural changes of cell organelles. Using variable pressure scanning electron microscopy and transmission electron microscopy, MPs have been localized in ten human placentas. In this study, we demonstrated for the first time the presence and localization in the cellular compartment of fragments compatible with MPs in the human placenta and we hypothesized a possible correlation between their presence and important ultrastructural alterations of some intracytoplasmic organelles (mitochondria and endoplasmic reticulum). These alterations have never been reported in normal healthy term pregnancies until today. They could be the result of a prolonged attempt to remove and destroy the plastic particles inside the placental tissue. The presence of virtually indestructible particles in term human placenta could contribute to the activation of pathological traits, such as oxidative stress, apoptosis, and inflammation, characteristic of metabolic disorders underlying obesity, diabetes, and metabolic syndrome and partially accounting for the recent epidemic of non-communicable diseases.

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Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice

Cited by 84 publications

References 40 publications

Microplastic Ingestion Induces Size-Specific Effects in Japanese Quail

Microplastic Ingestion Induces Size-Specific Effects in Japanese Quail

Pregnancy in the Era of the Environmental Crisis: Plastic and Pollution

Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas

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