Effects of oral buserelin on urinary LH secretion in male infants

Bassol, Susana; Barraza-Vázquez, Antonio; Nava, M; Recio, R

doi:10.1016/s0010-7824(97)00036-x

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…In adult men, ingestion of 0.6 mg buserelin dissolved in cow milk had no biological effect on both serum and urinary levels of LH [32]. On the other hand, 2-4 month old male infants receiving a single oral dose of 35 µg of the GnRH agonist buserelin mixed with breast milk showed an increase in urinary LH concentrations within 4-6 h after treatment [34]. These findings suggest that a s u f f i c i e n t q u a n t i t y o f b u s e r e l i n e s c a p e s gastrointestinal inactivation probably due to immaturity of enzyme function.…”

Section: Discussionmentioning

confidence: 92%

Study of Enteral versus Parenteral Application of the Gonadotropin Releasing Hormone Agonist Gonadorelin[6-D-Phe] (D-Phe6-LHRH) on LH Secretion in Goettinger Miniature Pigs

Brüssow

Kanitz

Tuchscherer

et al. 2007

Journal of Reproduction and Development

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Abstract. With respect to the assessment of residue situation and as a part of preclinical trials to determine the biological activities of potential gonadotropin releasing hormone (GnRH) residues in porcine organisms the GnRH agonist Gonadorelin[6-D-Phe] (D-Phe 6 -LHRH) was administered either enterally or intramuscularly (i.m.) to female Goettinger miniature pigs in order to evaluate the GnRHinduced luteinizing hormone (LH) surge. Gilts received an (i) enteral application of 10 mg D-Phe 6 -LHRH via a probang (enteral group, n=7), (ii) i.m. injection of 0.1 mg D-Phe 6 -LHRH (parenteral group, n= 5), or (iii) saline injection (control group, n=4). The GnRH and saline applications were repeated every second day with up to seven repetitions. Blood samples were collected via previously fitted jugular catheters immediately before injections, over an 8 h period in 1 h intervals beginning 2 h after injections, and at 24, 26, 28 and 30 h after applications. Enteral application of D-Phe 6 -LHRH induced an LH surge in 23 of 30 treatments. All gilts in the parenteral group exhibited LH release after each DPhe 6 -LHRH application (P<0.05), whereas no LH surges were observed after saline injection in the control group. A significant (P<0.05) LH rise to mean maximum LH concentrations of 3.25 ± 0.43 and 3.05 ± 0.26 ng/ml occurred in both the enteral and parenteral groups, but there was no difference in the time interval after GnRH (2.6 ± 0.3 vs. 2.3 ± 0.3 h) and the mean duration of LH peak (6.5 ± 0.4 and 6.8 ± 0.3 h) between the treatment groups. In conclusion, (i) enteral application of 10 mg D-Phe 6 -LHRH induced LH release in a physiological range from the pituitary of female minipigs, and (ii) neither an accumulative effect nor a cumulative LH response were found after repeated GnRH application. Furthermore, (iii) in regard to consumer protection and gonadotropin secretion, D-Phe 6 -LHRH residues can be excluded from having long-term effects.

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Section: Discussionmentioning

confidence: 92%

Study of Enteral versus Parenteral Application of the Gonadotropin Releasing Hormone Agonist Gonadorelin[6-D-Phe] (D-Phe6-LHRH) on LH Secretion in Goettinger Miniature Pigs

Brüssow

Kanitz

Tuchscherer

et al. 2007

Journal of Reproduction and Development

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show abstract

“…• reduce the insemination dose and sperm concentration to lower vaginal reabsorption; • study other routes of administration as suggested by Gudmundsson et al (1984), Roberts et al (1999), Bassol et al (1997) and Brüssow et al (2007); • evaluate the effects of the physiological status of does and semen treatment (i.e., estrus, secretions, inflammatory status, and seminal plasma); • improve the knowledge base regarding intraovarian factors that affect ovulation in rabbits (Lindner et al, 1977).…”

Section: Discussionmentioning

confidence: 99%