1977
DOI: 10.1136/gut.18.2.111
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Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man.

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Cited by 21 publications
(8 citation statements)
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“…Local mechanisms implicated in mucosal defence are; mucus-like alkaline secretions, mucosal hydrophilicity, rapid epithelial cell renewal, rich mucosal blood flow, mucosal sulphydryls and increased resistance of gland cells in deep mucosa to acid and peptic activity. [1] Calcium ions are involved in the regulation of acid secretion in the stomach [2,3] and has been considered as a serious contender responsible for the development of various types of ulcers. [4] Calcium influx plays an important role in stimulationsecretion coupling in mammalian oxyntic cells, an effect that can be inhibited by calcium channel blockers.…”
Section: Introductionmentioning
confidence: 99%
“…Local mechanisms implicated in mucosal defence are; mucus-like alkaline secretions, mucosal hydrophilicity, rapid epithelial cell renewal, rich mucosal blood flow, mucosal sulphydryls and increased resistance of gland cells in deep mucosa to acid and peptic activity. [1] Calcium ions are involved in the regulation of acid secretion in the stomach [2,3] and has been considered as a serious contender responsible for the development of various types of ulcers. [4] Calcium influx plays an important role in stimulationsecretion coupling in mammalian oxyntic cells, an effect that can be inhibited by calcium channel blockers.…”
Section: Introductionmentioning
confidence: 99%
“…Calcium plays an important role in a vari ety ofbiological processes [1,2], Many inves tigations demonstrate the influence of cal cium on gastric acid secretion and gastrin release [3][4][5][6][7], These findings only indicate that gastric secretion can be altered by exper imental modification of the calcium concen tration. In 1963, the hypothesis was put for ward that an increase of Ca++ influx into the cell following depolarization of the cell mem brane was important for the release of hor mones.…”
Section: Insulin • Verapamilmentioning
confidence: 88%
“…Each column represents the mean ± SEM. [33][34][35]. Furthermore, the calcimimetic compound KRN568 increased gastrin release in healthy subjects [36].…”
Section: Discussionmentioning
confidence: 99%