Objective: To study the interaction between a calcium channel blocker, amlodipine, and antiulcer agents, famotidine and omeprazole, in pylorus ligation-induced gastric ulcers in rats. Materials and Methods: Gastric ulcers were induced in albino rats by pyloric ligation as described by Shay et al. Effects of different doses of amlodipine, famotidine and omeprazole on volume, pH, acidity of gastric secretion and ulcer index were observed. In addition, the effects of low dose of amlodipine in combination with low dose of famotidine or omeprazole on the above Department of Pharmacology, Medical College, parameters were studied. Vadodara-390 001. Gujarat. Results: Amlodipine (0.5 mg and 1 mg/kg, i.p.), famotidine (4 mg/kg, i.p.) and omeprazole (4 mg/kg, i.p.) produced significant antiulcer effects. Low doses of famotidine (1 mg/kg, i.p.), Received: 14.12.2005 omeprazole (1 mg/kg, i.p.) and amlodipine (0.25 mg/kg, i.p.) did not alter the above parameters Revised: 6.4.2006 significantly. Combined administration of low dose of amlodipine (0.25 mg/kg) and famotidine Accepted: 28.4.2006 (1 mg/kg) showed significant antiulcer effects, which were apparent from the reduction in volume of gastric acid secretion, acidity and ulcer index with simultaneous increase in the intragastric Correspondence to: pH. Similarly, low dose of omeprazole (1 mg/kg) when combined with low dose of amlodipine Amol Bhave (0.25 mg/kg) also showed significant antiulcer effects. E-mail: Conclusion: Amlodipine produced significant antiulcer effects in pylorus-ligated model. albhave2005@rediffmail.com Combination of low doses of amlodipine with low doses of either famotidine or omeprazole produced significant antiulcer effects. It is suggested that the patients who received amlodipine therapy for some other clinical conditions are less prone to develop peptic ulcers; and even if ulcers develop, they would require lower doses of antiulcer agents like famotidine and omeprazole.