Effects of Oral Cromolyn on the Nasal Response due to Foods

Allergic Conjunctivitis and Nasal Allergy

“…These tests generate only static data at a certain time interval without any information on the dynamic aspects. 18,23,28,31,40,51]. As a well-established technique, CPTs are not usually included in routine diagnostic procedure [1•, 4, 5, 7, 8, 11, 12, 18, 23, 31, 39, 51].…”

“…We have recorded all three types of primary and secondary CR (immediate, late, or delayed) analogous to the three types of nasal response to food ingestion challenge. According to our preliminary data, the CR to food were prevented significantly by oral cromolyn (Nalcrom; Sanofi-Aventis, Paris, France) analogously to its effect on the nasal response caused by foods [28,40,52].…”

Diseases of the Sinuses

“…The role of food allergy and of foods in general in subjects with various allergic disorders, especially in those suffering from rhinitis (66,100,205,206), otitis media (100,207), sinusitis (59), bronchial asthma (208-211), atopic eczema (208.212, 213), urticaria (214), entero-colitis (208), and general malaise complaints (100,205,209,215), is still underestimated. The reasons for this underestimation may include:…”

“…Although the clinical manifestations are significantly related to the ingestion of additives, the antibodies of the IgE or other classes or sensitized T-lymphocytes have not yet been unequivocally found in the clinically affected patients (l00). Moreover, the disodium cromoglycate, administrated orally, has been shown to prevent significantly various symptoms owing to the food allergy, whereas this drug has been found to be completely ineffective on the symptoms following oral challenge with additives (66,100,206,210,211,213,214). This suggests that additives may produce the symptoms through nonimmunologic mechanisms, such as nonspecific hyperreactivity, direct mediator release without preceding antigen-antibody interaction, direct effects on the effector organs, or through a direct pharmacologic action, e.g., subtoxic effects (l 00).…”

“…The food ingestion challenge should not only be regarded as (1) an exclusive method for demonstrating the existence of the particular types of the organ response, e.g., nasal response owing to the food, but in combination with other parameters, such as X-ray of sin uses (59), echography (59), tympanography (207), lung functions (209,215), and so forth, but, (2) it should also be considered as the sole method for the confirmation of the causal role of the nasal mucosa and nasal response in other organs and their response to foods, such as middle ear, paranasal sinuses, bronchial tree, and eyes (59,66,100,205,208,214,215).…”