Effects of oral exposure to leachate from boiled-water treated plastic products on gut microbiome and metabolomics

Hu, Naifan; Zhang, Xue; Yu, Zhenfan; Du, Yurun; He, Xiaoxue; Pu, Lining; Pan, Degong; He, Shulan; Liu, Xiaojuan; Li, Jianping

doi:10.1016/j.jhazmat.2022.129605

Cited by 19 publications

(3 citation statements)

References 64 publications

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“…Previous reports suggested that leachate from boiled-water-treated plastic products may disrupt the gut microbiome and metabolome 5,26 . Yet, systematic studies of the consequences of multiple plastic leachate exposures on male reproductive health are lacking.…”

Section: Discussionmentioning

confidence: 99%

“…In developing nations, where roadside vendors and snack bars are common, freshly prepared, or hot liquid food is often served in disposable transparent plastic bags, making it a particularly pronounced trend. This lifestyle choice offers convenience and hygiene but also raises concerns about potential health risks associated with microplastics and leachate from these packaging materials 5 .…”

Section: Introductionmentioning

confidence: 99%

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Impact of leachate from boiled-water-treated plastic products on male reproductive health: insights from transcriptomic and metabolomic profiling

Yu,

Yao,

Meng

et al. 2023

Preprint

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Given the extensive use of plastic materials in modern society, there is an escalating concern about the potential risks associated with exposure to plastic products. This study investigated the impact of plastic leachates from boiled-water-treated products, including polypropylene (PP), high-density polyethylene (PEH), low-density polyethylene (PEL), polystyrene (PS), and polyethylene terephthalate (PET), on male reproductive health. Experimental mice were administered daily doses of the plastic leachates for 180 consecutive days. Histological analysis of the testes and epididymis was conducted, revealing vacuolization and absence of sperms in the seminiferous tubules of mice treated with PP, PEH, PEL, and PS, while PET exhibited lower reproductive toxicity. Furthermore, transcriptomic and metabolomic profiling were employed to identify key genes and metabolites related to plastic exposure.Transcriptome analysis showed significant changes in genes associated with spermatogenesis following exposure to leachates, while metabolome analysis indicated an impact on the lipid metabolism pathway. Overall, the study provides evidence that oral exposure to leachates from boiled-water-treated plastic products could negatively affect spermatogenesis and lipid metabolism, thereby posing risks to male reproductive health. These findings offer crucial insights into the potential risks associated with plastic consumption and may advocate for the selection of relatively safe plastic products for everyday use.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of leachate from boiled-water-treated plastic products on male reproductive health: insights from transcriptomic and metabolomic profiling

Yu,

Yao,

Meng

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…228,229 Nowadays microplastics and nanoplastics have entered a variety of organisms through the food chain, [311][312][313] which pose a serious threat to the ecological environment. [314][315][316][317] For instance, Jiang et al found that PS particles can induce oxidative stress, causing damage to mitochondria and lysosomes. This causes the cell cycle to be arrested in the G0/G1 phase, eventually leading to apoptosis.…”

Section: Methods For Removing Contaminants Produced During Photoaging...mentioning

confidence: 99%

A review on photochemical effects of common plastics and their related applications

Huang,

Wang

2023

Journal of Polymer Science

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The photochemical effects of plastics refer to a series of photochemical reactions of plastics under certain illumination conditions. In order to help researchers understand the research progress of photochemical effects of plastics, we will introduce photochemical effects of seven common plastics and discuss the influence of functional groups of polymers in plastics on the photochemical effects of plastics in this review. Based on this, we discuss the impact of photochemical effects on the properties of plastics and some factors affecting the surface photochemical effects of plastics. Last but not least, although in most cases the photochemical effects of plastics are extremely detrimental to the control of plastic pollution, some applications based on the photochemical effects of plastics will also be introduced in this review. It is believed that this review can provide some new ideas for the development of new and clean processes and some promising materials such as light‐responsive materials.

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Study on the impact of photoaging on the generation of very small microplastics (MPs) and nanoplastics (NPs) and the wettability of plastic surface

Huang

Wang

2023

Environ Sci Pollut Res

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Effects of oral exposure to leachate from boiled-water treated plastic products on gut microbiome and metabolomics

Cited by 19 publications

References 64 publications

Impact of leachate from boiled-water-treated plastic products on male reproductive health: insights from transcriptomic and metabolomic profiling

Impact of leachate from boiled-water-treated plastic products on male reproductive health: insights from transcriptomic and metabolomic profiling

A review on photochemical effects of common plastics and their related applications

Study on the impact of photoaging on the generation of very small microplastics (MPs) and nanoplastics (NPs) and the wettability of plastic surface

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