Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Misu, Naoko; Kamiya, Tetsuro; Kobayashi, Yuka; Hirako, Makoto; Nagao, Toshihiro; Shikano, Michiko; Matsuhisa, Eriko; Ando, Takashi; Adachi, Hiroshi; Kimura, Genjiro

doi:10.1540/jsmr.40.169

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…In an in vivo canine study with the gastric slow waves measured from a pair of electrodes placed on the gastric serosa, it was found that the frequency of the gastric slow waves decreased linearly with greater initial meal volume. A transient frequency dip in the gastric slow waves after a meal has been frequently and consistently reported in electrogastrographic studies [109][110][111][112][113][114]. Figure 4 shows a typical decrease in the slow wave frequency measured in a conscious dog using a pair of gastric serosal electrodes when the stomach was distended by an intragastric balloon; the frequency of the gastric slow wave was about 6 cpm before gastric distention and reduced to about 5 cpm during gastric distention.…”

Section: Roles Of Icc As Mechanoreceptorssupporting

confidence: 58%

Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies

Yin

Chen

2008

J Cellular Molecular Medi

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The aim of this article is to provide a better understanding of the roles of interstitial cells of Cajal (ICC) in regulating gastrointestinal motility by reviewing in vitro and in vivo physiological motility studies. Based on the in vitro studies, ICC are proposed to have the following functions: to generate slow waves, to mediate neurotransmission between the enteric nerves and the gastrointestinal muscles and to act as mechanoreceptors. However, there is limited evidence available for these hypotheses from the in vivo motility studies. In this review, we first introduce the major subtypes of ICC and their established functions. Three Kit mutant mouse and rodent models are presented and the loss of ICC subtypes in these mutants is reviewed. The physiological motility findings from various in vitroand in vivo experiments are discussed to give a critical review on the roles of ICC in generating slow waves, regulating gastrointestinal motility, mediating neural transmission and serving as mechanoreceptors. It is concluded that the role of ICC as pacemakers may be well established, but other cells may also be involved in the generation of slow waves; the theory that ICC are mediators of neurotransmission is challenged by the majority of the in vivo motility studies; the hypothesis that ICC are mechanoreceptors has not found supportive evidence from the in vivo studies yet. More studies are needed to explain discrepancies in motility findings between the in vitro and in vivo experiments.

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Section: Roles Of Icc As Mechanoreceptorssupporting

confidence: 58%

Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies

Yin

Chen

2008

J Cellular Molecular Medi

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“…Scintigraphy and electrogastrography detect gastric motion indirectly (Misu et al. ; Stacher et al. ).…”

Section: Introductionmentioning

confidence: 99%

“…Ultrasonographic evaluation of gut motility frequently depends on personal skill. Scintigraphy and electrogastrography detect gastric motion indirectly (Misu et al 1990;Stacher et al 1990). Moreover, radiography requires contrast medium which affects gut motility, and is limited by the exposure time, thus it is unsuitable to monitor slow contractions.…”

Section: Introductionmentioning

confidence: 99%

Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects

Teramoto

Shimizu²,

Yogo

et al. 2014

Physiol Rep

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Glutamate is thought to serve as a special signal for gut functions. We investigated the effects of monosodium l‐glutamate (MSG) on gastric emptying and duodenal motility. Ten healthy male volunteers underwent rapid magnetic resonance imaging (MRI) of the abdomen. Coronal images were successively acquired after ingestion of liquid meal (200 kcal in 200 mL: 9 g protein, 28.4 g carbohydrate, 5.6 g fat, 370 mg Na+) with and without 0.5% MSG. During the acquisition of MRI, participants breathed freely. In all participants, the gastric residual volume gradually decreased to 80.1 ± 14.2% without MSG and to 75.9 ± 14.3% with MSG after 60 min (P = 0.45 between the groups, n = 10). In two of 10 participants, gastric emptying slowed down significantly, whereas in the remaining eight participants, gastric residual volume decreased to 84.0 ± 13.1% without MSG, and to 73.0 ± 14.6% with MSG after 60 min (P = 0.015, n = 8). There was no difference in the shape of the stomach between groups. In four of the eight participants responding positively to MSG, the duodenum wall was sufficiently identified to quantify the motions. The inclusion of MSG enhanced duodenal motility, judging from changes in (1) the magnitude of the duodenal area, (2) the center of gravity, and (3) the mean velocity of the wall motions. The third parameter most significantly indicated the excitatory effect of l‐glutamate on duodenum motility (~ three‐ to sevenfold increase during 60 min, P < 0.05, n = 4). These results suggest that MSG accelerates gastric emptying by facilitating duodenal motility, at least in subjects with positive responses to MSG.

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“…Ultrasonographic evaluation of gut motility frequently depends upon personal skill. Scintigraphy and electrogastrograms detect gastric motion indirectly (Stacher et al 1990; Misu et al 2004). Also, radiography requires contrast medium, which affects gastrointestinal (GI) motility and is limited by the exposure time, being unsuitable for monitoring slow contractions.…”

mentioning

confidence: 99%

Assessment of gastric emptying and duodenal motility upon ingestion of a liquid meal using rapid magnetic resonance imaging

Teramoto¹,

Shimizu²,

Yogo

et al. 2012

Experimental Physiology

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Gastric emptying is achieved by co-operation between gastric and duodenal motor activity. Therefore, evaluation of gastric emptying and its associated mechanisms would benefit clinical therapy as well as medical research. Healthy volunteers underwent rapid magnetic resonance imaging (MRI) of the abdomen along the coronal plane after ingestion of a liquid meal. The gastric fundal and duodenal areas were quantified semi-automatically by self-developed segment software. The average gastric fundal area determined by the serosal end in 40 sequential images was reduced to ∼81% 30 min after and to ∼70% 60 min after ingestion of a liquid meal. The average duodenal area also decreased to ∼86% after 30 min and to 83% after 60 min. In contrast, changes in the centre of gravity increased to about fivefold after 30 min and to about threefold after 60 min. The mean velocity of the duodenal wall mimicked changes in the centre of gravity. The application of metoclopramide, a dopamine D 2 receptor antagonist, accelerated gastric emptying, presumably due to facilitated duodenal activity even immediately after liquid meal ingestion. The ingestion of water caused fast gastric emptying in 30 min, accompanied by high duodenal motility, but it ceased after 60 min, presumably reflecting complete gastric emptying. A rapid MRI scan visualized the association between gastric emptying and duodenal motility that could be modified by calories and dopaminergic neurotransmission. Changes in the centre of gravity and mean velocity of the duodenal wall appear to quantify the motility obtained from cine MRI accurately.

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Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Cited by 5 publications

References 29 publications

Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies

Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies

Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects

Assessment of gastric emptying and duodenal motility upon ingestion of a liquid meal using rapid magnetic resonance imaging

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