Effects of oral iron supplementation on some haematological parameters and iron biochemistry in neonatal dairy calves

Mohri, Mehrdad; Sarrafzadeh, F.; Seifi, Hesam A; Farzaneh, Nima

doi:10.1007/s00580-004-0523-5

Cited by 27 publications

(56 citation statements)

References 6 publications

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“…Various studies reported that administration of iron provided an increase in RBC parameters in calves (Bostedt et al 2000;Bunger et al 1986;Geisser et al 1991;Sakozy et al. 1984; Mohri et al 2004;Rajora et al 1995;Lindt and Blum 1994). In the present study, administration of iron in the test 1 group similarly provided an increase in RBC parameters although the difference with control group was not significant.…”

Section: Discussionsupporting

confidence: 61%

“…Scheidegger (1973), Bostedt and Schramel (1982), and Bostedt et al (1990) reported that a progressive reduction in serum Fe concentration occurs over the first few days of life. Various studies reported that the administration of iron provided an increase in serum iron concentration in calves (Mollerberg et al 1975b;Bomba et al 1986;Bunger et al 1986;Rajora et al 1995;Bostedt et al 2000;Steinhardt and Thielscher 2003;Mohri et al 2004). In the present study, the administration of iron provided no significant changes in serum Fe concentration between trial groups because there was a 12 to 13 days interval between iron injection and the first measurement of the concentrations in serum.…”

Section: Discussionmentioning

confidence: 96%

“…A progressive reduction in HCT, RBC, and Hb occurs over the first weeks of life (Mohri et al 2004;Swenson and Reece 1993;Cole et al 1997). Bomba et al (1986) reported the changes in RBC parameters and serum iron in calves fed milk replacer, hay, and grain mix.…”

Section: Discussionmentioning

confidence: 96%

“…Lindt and Blum (1994) showed that Fe deficiency anemia is frequent problem in veal calves but not in calves fed roughage, concentrates and mineral/vitamin supplements but Bunger et al (1980) concluded that unrestricted feeding on concentrate rich in iron during colostral period did not prevent Fe deficiency and believed that anemia developing in the first month of life was not physiological but was due to Fe deficiency. However, numerous studies showed that the administration of iron provided an increase in hematological parameters and a better growth in calves (Mollerberg et al 1975a;Sakozy et al 1984;Bunger et al 1986;Geisser et al 1991;Gygax et al 1993;Lindt and Blum 1993;Bostedt et al 2000;Mohri et al 2004).…”

Section: Introductionmentioning

confidence: 97%

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Effects of parenteral supply of iron and copper on hematology, weight gain, and health in neonatal dairy calves

et al. 2008

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The objective of the present study was to examine the effects of parenteral administration of iron and copper on hematological parameters, weight gain, and health of neonatal dairy calves in the period when iron and copper deficiency could be existed. Twenty-four Holstein calves were used for the experiment and randomly assigned to four different treatments. Treatments consisted of (1) control (no injections of Fe and Cu), (2) test 1 (1000 mg Fe as fe-dextran was injected to each calf at day 2 of age), (3) test 2 (160 mg Cu as methionine-copper complex was injected to each calf at day 14 of age), and (4) test 3 (Fe and Cu were injected to each calf as mentioned previously). Blood samples were collected from all of the calves within 24-48 hours after birth and at 7, 14, 21 and 28 days of age for measuring hematological parameters and within 24-48 hours after birth and at 14, 21 and 28 days of age for the determination of iron, copper, TIBC concentrations, and AST activity. Anti-coagulated blood was analyzed shortly after collection for: number of red blood cell (RBC), hemoglobin (Hb), heamatocrit (HCT), total leukocyte count (WBC), Platelet (Plt), MCH, MCV, MCHC, and differential leukocyte counts. The amounts of iron, copper, TIBC, and AST were measured in serum. Group had significant effects on the amounts of HCT, RBC, hemoglobin, MCV, neutrophil, weekly weight gain, and daily gain during each week (p < 0.05). Sampling time had significant effects on the amounts of RBC, MCV, MCH, MCHC, WBC, neutrophil, lymphocyte, monocyte, platelet, fibrinogen, copper, TIBC, AST, weight, weekly gain and, daily gain during each week (p < 0.05). significant interactions between sampling time and group were seen for HCT, RBC, hemoglobin, MCV, platelet, total protein, fibrinogen, iron, and TIBC (p < 0.05). Improved RBC parameters and MCV were seen in calves of group 4 (test 3) in comparing with control group. Total and daily gains were also significantly improved in test groups in comparing with control group (p < 0.05). No significant difference was seen for the days of treatment between groups.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

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Effects of parenteral supply of iron and copper on hematology, weight gain, and health in neonatal dairy calves

et al. 2008

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“…However, Bunger et al [5] concluded that unrestricted feeding on concentrate rich in iron during colostral feeding period did not prevent Fe deficiency and believed that anemia developing in the first month of life was not physiological but was due to Fe deficiency. Numerous studies showed that the administration of iron to calves (orally or parenterally) provided an increase in hematological parameters and a better growth in calves [6][7][8][9][10][11][12][13][14][15]. On the other hand, there is a report that indicated iron supplementation (injection) had no effect on red blood cell (RBC) parameters and health of supplemented calves [16].…”

mentioning

confidence: 98%

Effects of Parenteral Supply of Iron on RBC Parameters, Performance, and Health in Neonatal Dairy Calves

Mohri

Poorsina²,

Sedaghat

2009

Biol Trace Elem Res

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The present study was designed to evaluate the effects of parenteral iron on red blood cell parameters, performance, and health in dairy Holstein calves. Twenty neonatal calves were equally divided at random into two groups, one of which served as controls. Care was taken to ensure homogeneity of sex, age, and general health status of the animals. The controls received a normal diet and water ad libitum, while the study animals were injected with 1 g iron as Fe-dextran 2 days after birth. A daily record was kept of the calves' weight and growth parameters. At periods of 24-48 h after birth and at 14, 28, and 42 days of age, jugular blood was drawn from all the experimental and control animals to measure the packed cell volume, red blood count, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and iron levels. At the start of the experiments, there were no significant differences between these parameters between the two study groups (p > 0.05). With time, significant differences were seen between most of the values measured (p < 0.05) except for the mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and iron level. Significant differences were seen for total weight gain and mean daily weight gain, which were higher in the iron-supplemented group (p < 0.05).

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Effects of oral or parenteral iron supplementation on haematological parameters, blood iron status and growth in newborn calves fed milk replacer

et al. 2023

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BackgroundThis study aimed to assess the influence of early life iron supplementation on the haematological parameters of calves fed milk replacer on a high plane of nutrition.MethodsThirty calves were allocated to receive either a sham treatment (CON), injection of 1000 mg Fe3+ (INJ) or oral administration of 1050 mg Fe3+ (ORAL), all administered less than 1 hour after birth. Blood was obtained before treatment, on days 1, 3, 5 and 7 of life and once weekly until week 9. Samples were analysed for haemoglobin (Hb), packed cell volume (PCV) and estimated transferrin saturation (%TSAT).ResultsThe Hb and PCV of calves in the INJ and ORAL groups were above the values of those in the CON group throughout the study. Hb and PCV of the CON group remained within the reference range for calves. The %TSAT exceeded reported ranges in the ORAL group in the first week. Values for the CON group were below the INJ and ORAL groups throughout the entire study. Average daily gain did not differ between treatments.LimitationsThe sample size was insufficient to assess the influence of iron supplementation on disease development. Furthermore, the study was set in a controlled environment and not performed under field conditions.ConclusionsOral and subcutaneous iron administration had similar effects on haematological development but resulted in numerically different transferrin saturation. Control animals showed lower Hb and PCV but did not develop overt anaemia.

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Effects of oral iron supplementation on some haematological parameters and iron biochemistry in neonatal dairy calves

Cited by 27 publications

References 6 publications

Effects of parenteral supply of iron and copper on hematology, weight gain, and health in neonatal dairy calves

Effects of parenteral supply of iron and copper on hematology, weight gain, and health in neonatal dairy calves

Effects of Parenteral Supply of Iron on RBC Parameters, Performance, and Health in Neonatal Dairy Calves

Effects of oral or parenteral iron supplementation on haematological parameters, blood iron status and growth in newborn calves fed milk replacer

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