Effects of oral L-carnitine and DL-carnitine supplementation on alloxan-diabetic rats

Bazotte, Roberto Barbosa; Lopes-Bertolini, Gisele

doi:10.1590/s1516-89132012000100010

Cited by 12 publications

(8 citation statements)

References 40 publications

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“…L-carnitine glucose-lowering effects in diabetes is controversial. several studies showed glucose-lowering effect upon L-carnitine administration but some other studies were not successful to show this hypoglycemic property of L-carnitine [15,27,[29][30][31][32]. This controversy could be contributed to the route of L-carnitine administration in different studies.…”

Section: Resultsmentioning

confidence: 99%

Carnitine effects on serum and pancreas inflammatory response in diabetic rats

Masoumi‐Ardakani¹,

Fallah²,

Shahouzehi³

2019

Ukr.Biochem.J

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diabetes is a group of disorders characterized by elevated blood glucose and insulin secretion defect. Previous studies have reported L-carnitine beneficial and hypoglycemic effects in diabetic models. L-carnitine anti-inflammatory properties in diabetes were not assessed perfectly, and there is a lack of information about this matter. Therefore, we designed this study and evaluated L-carnitine different doses supplementation on pro-inflammatory cytokines in STZ-induced diabetic rats' pancreas and serum. We selected 48 male rats (200 ± 10 g) and randomly divided them into six groups (n = 8). Group 1, control; group 2, Diabetic control (DC); groups 3-6, STZ-induced diabetic rats which received L-carnitine different doses as follow; 300, 200, 100 and 50 mg/kg/day by intraperitoneal injection for 5 weeks. When the study ended, serum and pancreas samples were collected and cytokines levels were measured by specific ELISA kits. Our results showed that in diabetic rats, pro-inflammatory cytokines levels were elevated. Two L-carnitine doses 300 and 200 mg/ kg/day showed beneficial effects and 300 mg/kg/day showed more effective and significant effects than other doses. The 300 mg/kg significantly reduced IL-1β and IL-6 levels in pancreas and serum. Our data proved the protective effects of intraperitoneal L-carnitine administration against diabetes and inflammation in diabetic rats. Indeed, l-carnitine long term supplementation through the intraperitoneal injection can be considered as a good and safe therapeutic strategy in diabetes.

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Section: Resultsmentioning

confidence: 99%

Carnitine effects on serum and pancreas inflammatory response in diabetic rats

Masoumi‐Ardakani¹,

Fallah²,

Shahouzehi³

2019

Ukr.Biochem.J

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“…It demonstrated that long term L-carnitine supplementation reduced TG and cholesterol but hyperglycemia was still present in diabetic rats [15]. on the other hand, Bazotte R. B. and Lopes-Bertolini G. showed that L-carnitine administration showed no significant effects on blood glucose and total cholesterol but normalized blood TG levels in diabetic rats [16]. Rodrigues B. and colleagues were suggested that high dose of L-carnitine reduced diabetes severity and also improved cardiac function [10].…”

Section: Resultsmentioning

confidence: 99%

“…But data about hypoglycemic effects of L-carnitine in dia betes are inconsistent [1,10,15,16] and the mecha nism of L-carnitine beneficial effects are not fully understood, therefore, we designed this study to evaluate oral L-carnitine supplementation effects on adiponectin and insulin circulating levels and also, expression of amPK, PPARγ and aPPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding (PTB) domain and leucine zipper motif) genes in liver of STZ-induced diabetic rats. materials and methods materials.…”

mentioning

confidence: 99%

Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver

Shahouzehi¹,

Barkhordari²,

Aminizadeh³

et al. 2017

Ukr.Biochem.J.

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“…The elevation of serum glucose above 7.5 mmol/L was considered as an index and confirmation of diabetes induction (Nazari et al, 2016). One diabetic group (n = 15) received LC 300 mg kg −1 day −1 (Bazotte & Bertolini, 2012) in drinking water concomitant with HF/ HC diets for 28 days. The other diabetic group (n = 15; diabetic control) received only the HF/HC diet for 28 days.…”

Section: Experimental Designmentioning

confidence: 99%