Effects of oral levamisole as an adjuvant to hepatitis B vaccine in health-care workers non-responders to previous vaccinations: A randomised controlled trial

Effects of adjuvants (granulocyte-macrophage colony-stimulating factor, levamisole, adjuvant system 04, adjuvant system 02B) on enhancing immune response to hepatitis B vaccine: a systematic review and meta-analysis

“…The data were analyzed through a random-effects meta-analysis model using R programming language and Stata (version 11.2).Results: A total of 36 article including 4805 participants were included in this review. The findings revealed that the response rate to HBV vaccination for levamisole in the study group was 46.1% (95% confidence interval (CI) [38][39][40][41][42][43][44][45][46][47][48][49][50][51]), and that was 43.8% (95% CI [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]) in the control group. These values were also 56.8% (95% CI [53-60]) and 43.3% (95% CI [40-46.7]) for GM-CSF in the study group and the control group, respectively.…”

“…These values were also 56.8% (95% CI [53-60]) and 43.3% (95% CI [40-46.7]) for GM-CSF in the study group and the control group, respectively. Considering AS04, the response rate in the study group was 50.8% (95% CI ), and that was 45.8% (95% CI [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]) in the control group. Moreover, these values were 86.3% (95% CI ) and 47.6% (95% CI ) for AS02B in the study group and the control group, respectively.…”