Effects of oral paricalcitol therapy on arterial stiffness and osteopontin in hypertensive patients with chronic kidney disease and secondary hyperparathyroidism

Abstract

Treatment with oral paricalcitol in hypertensive subjects suffering from CKD stages 3-5 and secondary hyperparathyroidism is accompanied by amelioration of arterial stiffness as reflected by the reduction of carotid-femoral PWV.

Effect of Vitamin D Supplementation on Vascular Function and Inflammation in Patients with Chronic Kidney Disease: A Controversial Issue

“…The effect of vitamin D supplementation on diastolic BP was also described in five trials . The pooled analysis showed that diastolic BP had no difference between the vitamin D intervention and control groups (SMD, 0.01; 95% CI, −0.26 to 0.27; P = 0.97; Figure ).…”

“…Six studies described the changes in systolic BP . The results of the pooled analysis demonstrated that systolic BP was not different in the group receiving vitamin D compared with the control group (SMD, −0.04; 95% CI, −0.29 to 0.22; P = 0.77; Figure ).…”

“…Five studies reported the effect of vitamin D intake on the levels of PWV . The pooled results of five studies suggested that vitamin D supplementation had no significant difference on PWV (SMD, −0.13; 95% CI, −0.38 to 0.13; P = 0.33; Figure ).…”

“…A total of 579 patients were included in these 10 studies, among which 313 were treated with vitamin D and the control group included 266 who received placebo. Of these, two records were included for FMD change, and five , six , five , and six records were included in this meta‐analysis of PWV, systolic BP, diastolic BP, and CRP, respectively. Among the included CKD patients, those reported in four studies received dialysis treatment.…”

Health Risks of Hypovitaminosis D: A Review of New Molecular Insights

“…Notably, paricalcitol have a therapeutic advantage compared to calcitriol that is consistent with the suppression of renin production (reduced side effects of hypercalcemia) and lack of vascular calcium deposition, which instead causes aortic calcifications with arterial stiffness and hypertension regardless of plasma Ca and P levels. The reason for the selective effect of paricalcitol has to be better elucidated since its clearance from the bloodstream is comparable to that of 1,25(OH)2D [ 47 , 48 , 49 , 50 , 51 ].…”