Effects of oral versus long-acting antipsychotics on social functioning: A psychiatrists’ survey in India

Gundugurti, Prasad Rao; Nagpal, Rajesh; Sheth, Ashit; Narang, Prashant; Gawande, Sonal; Singh, Vikram

doi:10.1016/j.ajp.2017.08.002

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…However, Ashong et al, didn't found any evidence of LAIs among schizophrenic patient because of cost, insurance coverage, treatment setting, negative attitudes of healthcare professionals and patients, fear, and pain on injection [1]. But, in India perceived expenses of LAIs is an important cause of low LAI using [8][9][10]. Mukherjee et al, found only 4.42% respondents were found to get parenteral preparations [5].…”

Section: Discussionmentioning

confidence: 99%

Pattern of psychotropic prescription in a tertiary care hospital of Bangladesh: a cross-sectional analysis of prescription photos

Hussain¹,

Alam²,

Mali³

et al. 2018

Ment Health Addict Res

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Section: Discussionmentioning

confidence: 99%

Pattern of psychotropic prescription in a tertiary care hospital of Bangladesh: a cross-sectional analysis of prescription photos

Hussain¹,

Alam²,

Mali³

et al. 2018

Ment Health Addict Res

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“…There were no significant differences observed among all formulations regarding satisfaction on the Drug Attitude Inventory-10 (DAI-10) scores (p > 0.05). Gundugurti et al [41] surveyed psychiatrists in India on oral vs. LAI use regarding social functioning. They found that oral second-generation antipsychotic tablets were more commonly prescribed in acute treatment, whereas in the chronic phase, patients were treated with either tablets or LAIs.…”

Section: Reasons For Switching To Laismentioning

confidence: 99%

Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom

Qadir,

Kar,

Ball

et al. 2023

Pharmacy

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The aim of this survey of psychiatrists from the UK and India was to compare their opinions on antipsychotic medication choice and their experiences of such medications’ effectiveness and tolerability in patients who were newly diagnosed with acute schizophrenia. Following ethical approval, a cross-sectional online survey of psychiatrists from the UK and India was conducted. Ninety-five responses were received from each country. The most selected first-line APDs in both countries were olanzapine (47.5%), risperidone (42.8%) and aripiprazole (25.3%). A total of 60% of psychiatrists from India (60%) and 48% from the UK (48%) selected ‘medication efficacy’ as the main factor in their choice. Reassessment and consideration to switch most often took place within 4–6 weeks (53.7%) and 3–6 months (11.6%). The major reasons for switching antipsychotic medications were poor clinical efficacy (69%) and lack of tolerability (45%). Nonadherence was the most common reason for relapse (90% of UK psychiatrists and 70% of Indian psychiatrists), followed by illicit drug use (27.6%). The most commonly reported side effects that led to nonadherence were weight gain (10.8%), drowsiness (10.4%), erectile dysfunction and movement disorders (equally 8.7%). It was concluded that olanzapine, risperidone and aripiprazole are the most commonly selected as the initial treatment choice by psychiatrists from India and the UK. They are perceived as widely effective and well tolerated.

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“…A total of 12 functional definitions of relapse were identified, listed as follows: Hospitalization (all causes) (15 studies) 7,[17][18][19][20][21][22][23][24][25][26][27][28][29][30] ; Psychiatricrelated hospitalization (overall psychotic, mental/behavioral disorders) (7 studies) 20,[31][32][33][34][35][36] ; schizophrenia-related hospitalizations (specific to symptoms of schizophrenia) (7 studies) [37][38][39][40][41][42][43] ; schizophrenia-related emergency department (ED) visits (3 studies) [39][40][41] ; Psychiatric-related ED visits (3 studies) 18,29,30 ; Increase in the Clinical Global Impression Scale (CGI-S) score (2 studies) 17,44 or according to psychiatrist assessment (1 study) 45 ; Symptom re-emergence (1 study) 20 ; Intentional overdose events leading to ED visits or hospital admissions (1 study) 30 ; Suicidality (including ideation and attempts) leading to ED visits or hospital admissions (1 study) 30 ; ED visits (unspecified reasons) (1 study) 7 ; Medication switch (1 study). 19...…”

Section: Definitions and Measurements Of Schizophrenia Relapsementioning

confidence: 99%

Impact of schizophrenia relapse definition on the comparative effectiveness of oral versus injectable antipsychotics: A systematic review and meta‐analysis of observational studies

Cristarella

Castillon

Nepveu

et al. 2022

Pharmacology Res & Perspec

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Although relapse is an important outcome to measure the effectiveness of schizophrenia treatment, no standard definition exists. This review aimed at identifying definitions and measurements of schizophrenia relapse in observational studies of long‐acting injectables (LAIs) versus oral antipsychotics (OAPs) and at determining their impact on heterogeneity of comparative effectiveness estimates. A systematic review was conducted using MEDLINE and Embase (01 January 2010–11 November 2019 [date last searched]). Pragmatic searches of gray literature and snowballing were also conducted. Search outputs were screened independently by two assessors at first stage, and full‐text of potentially eligible sources at second stage. For each retained source, definition and measurement of relapse, study methods, and comparative effectiveness estimates were extracted. Heterogeneity of estimates was assessed using I2 statistic with a threshold of 50% for substantial heterogeneity. Literature search yielded 543 sources and pragmatic searches, 21, of which 35 were eligible. Twelve definitions of relapse were found based on hospitalization/emergency department (ED) data (28 studies) or clinical assessment (5 studies). No definition was provided in five studies. According to quantitative analyses, in studies defining relapse as schizophrenia‐related hospitalization and/or ED visits over 1‐year follow‐up, LAIs were significantly more effective than OAPs. For studies measuring relapse based on all‐cause hospitalization, heterogeneity was too high for pooling; yet this definition is the most frequently found in pooled estimates published in the literature. Schizophrenia relapse definitions led to substantial heterogeneity of comparative effectiveness estimates of LAIs versus OAPs. Creating study subgroups based on relapse definition effectively reduces statistical heterogeneity.

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Effects of oral versus long-acting antipsychotics on social functioning: A psychiatrists’ survey in India

Cited by 10 publications

References 26 publications

Pattern of psychotropic prescription in a tertiary care hospital of Bangladesh: a cross-sectional analysis of prescription photos

Pattern of psychotropic prescription in a tertiary care hospital of Bangladesh: a cross-sectional analysis of prescription photos

Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom

Impact of schizophrenia relapse definition on the comparative effectiveness of oral versus injectable antipsychotics: A systematic review and meta‐analysis of observational studies

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