Effects of orally administered fingerroot (Boesenbergia pandurata) extract on oxazolone-induced atopic dermatitis-like skin lesions in hairless mice

Kim, Myung Suk; Pyun, Hee Bong; Hwang, Jae Kwan

doi:10.1007/s10068-013-0075-z

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…1) is a natural chalcone derivative isolated from Boesenbergia pandurata Roxb. (B. pandurata), which has bioactivities, including anti-obesity, anticancer, and antioxidant effects [12]. Previous results reported that panduratin A effectively inhibited the growth of periopathogens, including P. gingivalis [13,14].…”

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confidence: 99%

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Kim¹,

Kim²,

Kim³

et al. 2018

Journal of Microbiology and Biotechnology

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Periodontitis is an inflammatory disease caused by microbial lipopolysaccharide (LPS), destroying gingival tissues and alveolar bone in the periodontium. In the present study, we evaluated the anti-inflammatory and anti-osteoclastic effects of panduratin A, a chalcone compound isolated from , in human gingival fibroblast-1 (HGF-1) and RAW 264.7 cells. Treatment of panduratin A to LPS-stimulated HGF-1 significantly reduced the expression of interleukin-1β and nuclear factor-kappa B (NF-κB), subsequently leading to the inhibition of matrix metalloproteinase-2 (MMP-2) and MMP-8 compared with that in the LPS control (** < 0.01). These anti-inflammatory responses were mediated by suppressing the mitogen-activated protein kinase (MAPK) signaling and activator protein-1 complex formation pathways. Moreover, receptor activator of NF-κB ligand (RANKL)-stimulated RAW 264.7 cells treated with panduratin A showed significant inhibition of osteoclastic transcription factors such as nuclear factor of activated T-cells c1 and c-Fos as well as osteoclastic enzymes such as tartrate-resistant acid phosphatase and cathepsin K compared with those in the RANKL control (** < 0.01). Similar to HGF-1, panduratin A suppressed osteoclastogenesis by controlling MAPK signaling pathways. Taken together, these results suggest that panduratin A could be a potential candidate for development as a natural anti-periodontitis agent.

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confidence: 99%

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Kim¹,

Kim²,

Kim³

et al. 2018

Journal of Microbiology and Biotechnology

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“…[Zingiberaceae] is recognized as a medicinal plant and contains various bioactive compounds, including pinostrobin, cardamon, boesenbergin, 5,7-dihydroxy-flavone, 1,8-cineole, and pandurate A [7]. Panduratin A is known for its active biological properties and also exhibits anti-inflammatory, antioxidative, antibacterial, and antiobesity activities [8].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Boesenbergia rotunda Extract on 3T3-L1 Preadipocytes and Its Use in Capsaicin-Loaded Body-Firming Formulation: In Vitro Biological Study and In Vivo Human Study

Sritananuwat,

Samseethong,

Jitsaeng

et al. 2024

Cosmetics

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Boesenbergia rotunda has been used as an antiobesity agent by suppressing adipogenesis. This study aimed to investigate the biological activity of B. rotunda on preadipocyte cells and to evaluate the effectiveness and safety of using B. rotunda extract in a capsaicin-loaded body-firming formulation. The antiadipogenesis of B. rotunda ethanolic extract was evaluated in 3T3-L1 preadipocyte cells. After the application of the B. rotunda extract-loaded body-firming formulation on the skin of volunteers for 28 d, thigh circumference, melanin index, and skin erythema were investigated. The results showed that the ethanolic extract of B. rotunda was not toxic toward 3T3-L1 cells at concentrations lower than 20 µg/mL, with antiadipogenesis of the B. rotunda extract occurring at a concentration of 1 µg/mL. The B. rotunda extract containing panduratin A was mixed with capsaicin body-firming products and successfully permeated into and through the skin. Applying this formulation to the thighs of the volunteers two times a day for 21 days led to a significant reduction in thigh circumference and melanin index. A slight elevation in skin erythema was observed, but there was no significant increase in redness or pain. In conclusion, the B. rotunda extract contained bioactive compounds that inhibited antiadipogenesis. The formulations containing B. rotunda extract and capsaicin showed potential as effective body-firming products.

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“…This could be attributed to the immunomodulatory effects of fingerroot extract in rodent models. Previous studies have reported decreases in inflammatory cytokines and modulation of bone metabolism following oral administration of fingerroot extract in rat and mouse models [43] , [44] . Furthermore, a decrease in creatinine levels was observed in male rats receiving medium and high doses of fingerroot extract formulation.…”

Section: Discussionmentioning

confidence: 92%

Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

Techapichetvanich,

Tangpanithandee,

Supannapan

et al. 2024

Toxicology Reports

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Effects of orally administered fingerroot (Boesenbergia pandurata) extract on oxazolone-induced atopic dermatitis-like skin lesions in hairless mice

Cited by 8 publications

References 25 publications

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Effectiveness and Safety of Boesenbergia rotunda Extract on 3T3-L1 Preadipocytes and Its Use in Capsaicin-Loaded Body-Firming Formulation: In Vitro Biological Study and In Vivo Human Study

Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

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