Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

Ishibashi, Masaru; Takano, Shinobu; Yanagida, Hiroki; Takatsuna, Masafumi; Nakajima, Koji; Osuga, Yutaka; Wayner, M.J.; Sasaki, Kohsuke

doi:10.1016/j.peptides.2004.10.014

Cited by 90 publications

(68 citation statements)

References 69 publications

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“…A significant part of this projection arises from orexincontaining cells; indeed, the innervation of the PVT is among the most dense in the brain (Fig. 3), and orexin depolarizes PVT neurons (Ishibashi et al, 2005). Third, and most important for the current model, the LH more directly reaches widespread areas of striatum (well beyond the accumbens) via this midline thalamic projection, as discussed below.…”

Section: How Does the Striatum Become Engaged By Hypothalamic Systems?mentioning

confidence: 83%

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Kelley

Baldo

Pratt

2005

J of Comparative Neurology

313

286

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We elaborate herein a novel theory of basal ganglia function that accounts for why palatable, energy-dense foods retain high incentive value even when immediate physiological energy requirements have been met. Basal ganglia function has been studied from the perspective of topographical segregation of processing within parallel circuits, with primary focus on motor control and cognition. Recent findings suggest, however, that the striatum can act as an integrated unit to modulate motivational state. We describe evidence that the striatal enkephalin system, which regulates the hedonic impact of preferred foods, undergoes coordinated gene expression changes that track current motivational state with regard to food intake. Striatal enkephalin gene expression is also downregulated by an intrastriatal infusion of a cholinergic muscarinic antagonist, a manipulation that greatly suppresses food intake. To account for these findings, we propose that signaling through a hypothalamic-midline thalamic-striatal axis impinges on the cholinergic interneurons of the striatum, which via their large, overlapping axonal fields act as a network to modulate enkephalin-containing striatal output neurons. A key relay in this circuit is the paraventricular thalamic nucleus, which receives convergent input from orexin-coded hypothalamic energy-sensing and behavioral state-regulating neurons, as well as from circadian oscillators, and projects to cholinergic interneurons throughout the striatal complex. We hypothesize that this system evolved to coordinate feeding and arousal, and to prolong the feeding central motivational state beyond the fulfillment of acute energy needs, thereby promoting "overeating" and the consequent development of an energy reserve for potential future food shortages.

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Section: How Does the Striatum Become Engaged By Hypothalamic Systems?mentioning

confidence: 83%

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Kelley

Baldo

Pratt

2005

J of Comparative Neurology

313

286

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“…In fact, it is known that Orx/Hcrt controls general arousal (Sakurai et al, 2010); for instance, it has been described that expectation of food rewards induces the activation of neurons that contain Orx/Hcrt receptors within the PVT (Choi et al, 2010). Most neurons in the PVT are sensitive to Orx-A/Hcrt-1 and Orx-B/Hcrt-2, and the prefrontal cortex is an important target of Orx/Hcrt-activated PVT neurons (Ishibashi et al, 2005;Huang et al, 2006). The present results suggest that Orx/Hcrt inputs to the PVT facilitate cortical activation that is linked to general arousal (Sato-Suzuki et al, 2002), which could explain the reinstatement of cocaine seeking.…”

Section: Discussionmentioning

confidence: 99%

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

Matzeu

Kerr

Weiss

et al. 2016

J Pharmacol Exp Ther

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Orexin/hypocretin (Orx/Hcrt) projections from the lateral hypothalamus to the paraventricular nucleus of the thalamus (PVT) are implicated in drug addiction. Specifically, the posterior section of the PVT (pPVT) innervates brain structures that modulate motivated behavior. This study investigated the role of pPVTOrx/Hcrt transmission in cocaine-seeking behavior. Because the effects of Orx/Hcrt are mediated by two Orx/Hcrt receptors (Hcrt-r1 and Hcrt-r2), we examined the extent to which Hcrt-r1 and Hcrt-r2 are involved in Orx/Hcrt-induced cocaine seeking. Male Wistar rats were made cocaine dependent by selfadministering cocaine 6 hours/day (long access) for 21 days. After self-administration training, the rats underwent daily extinction training, during which cocaine was withheld. After extinction, the rats were injected into the pPVT with Orx-A/Hcrt-1 (0-2 mg) alone or, using a single dose of 0.5 mg, in combination with an Hcrt-r1 antagonist (SB334867; 0-15 mg) or an Hcrt-r2 antagonist (TCSOX229; 0-15 mg). Orx-A/Hcrt-1 alone reinstated (primed) cocaine seeking. Unexpectedly, coadministration of Orx-A/Hcrt-1 with SB334867 did not have any effects on Orx-A/Hcrt-1-induced reinstatement, whereas when coadministered with Orx-A/Hcrt-1, TCSOX229 prevented cocaine-seeking behavior. These results indicate that Hcrt-r2 in the pPVT mediates the reinstating effect of Orx-A/Hcrt-1 in animals with a history of cocaine dependence and further identify Hcrt-r2 as a possible molecular target that can guide future therapeutic approaches for the prevention of drug-seeking behavior.

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“…Electrophysiological studies indicate these peptides have both pre-and postsynaptic excitatory effects ) and produce membrane depolarization when direct responses are observed. This depolarization is mediated by a variety, and probably a mixture, of mechanisms including the closure of K ϩ channels (Bayer et al 2002;Bisetti et al 2006;Grabauskas and Moises 2003;Hoang et al 2003Hoang et al , 2004Hwang et al 2001;Ishibashi et al 2005;Ivanov and Aston-Jones 2000), forward activation of the electrogenic Na ϩ /Ca 2ϩ exchanger (NCE) (Burdakov et al 2003;Eriksson et al 2001;Wu et al 2002Wu et al , 2004, and activation of a cation current (Murai and Akaike 2005;Ferguson 2002, 2003).…”

Section: Introductionmentioning

confidence: 99%

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca²⁺ Transients Mediated by L-Type Calcium Channels

Kohlmeier

Watanabe²,

Tyler³

et al. 2008

Journal of Neurophysiology

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Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

Cited by 90 publications

References 69 publications

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca²⁺ Transients Mediated by L-Type Calcium Channels

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Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

Cited by 90 publications

References 69 publications

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca2+ Transients Mediated by L-Type Calcium Channels

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Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca²⁺ Transients Mediated by L-Type Calcium Channels