Effects of organophosphorus pesticides and their ozonation byproducts on gap junctional intercellular communication in rat liver cell line

Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

“…Most reports focused on neurotoxicity, while far less is known regarding the non-cholinergic effects, especially actions on liver connexins. Wu et al (2007) demonstrated that parathion, methyl parathion, diazinon and malathion inhibited GJIC in rat liver cell cultures. These OP compounds elicit this effect themselves, since their oxons and ozonation byproducts produced no marked effect.…”

Potential cytotoxic effect of Anilofos by using Allium cepa assay

“…Organophosphorus pesticides (OPs) are one of the most important groups of pesticides which have been widely used in agriculture, industry and hygiene (Bello-Ramírez et al 2000;Ballesteros and Parrado 2004;Wu et al 2007). OPs, such as herbicides and insecticides, increased economic profits significantly, however, the abusive usage of these pesticides during decades caused serious hazards on environmental and human health (Mann et al 2009;Burridge et al 2010).…”

Insight into natural medium remediation through ecotoxicity correlation with clay catalyst selectivity in organic molecule ozonation

“…This indicates a beneficial effect of ozonation on water treatment even for the production of drinking water without the formation of GJIC toxicity. 72 In other works, oxon and diazoxon were found to be more toxic than their precursor compounds, 52 thereby explaining the slight increase in the relative mortality for prolonged ozonation after previous toxicity depletion in the presence of clay catalysts. Values close to unity were obtained for low DAZ degradation yields and for less acidic clay catalysts such as NaMt and hydrotalcite.…”