Effects of organotin compounds on pubertal male rats

Grote, Konstanze

doi:10.1016/j.tox.2004.05.003

Cited by 102 publications

(78 citation statements)

References 70 publications

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“…In a recent laboratory study, TPT induced anti-androgenic effects in pubertal male rats. Administration of 2, 6, and 12 mg/kg/day decreased testis weight; epididymis and prostate weights were reduced at 6 and 12 mg/kg/day, and seminal vesicle weights at 6 mg/kg/day (Grote et al 2004). In rats the histopathological effects of 2 or 6 mg TPT/kg b.w.…”

Section: Triphenyltin Compoundsmentioning

confidence: 90%

Laboratory Tests with Androgenic and Anti-Androgenic Pesticides – Comparative Studies on Endocrine Modulation in the Reproductive System of Invertebrates and Vertebrates

Watermann¹,

Gnass²,

Kolodzey³

et al. 2011

Pesticides in the Modern World - Effects of Pesticides Exposure

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Section: Triphenyltin Compoundsmentioning

confidence: 90%

Laboratory Tests with Androgenic and Anti-Androgenic Pesticides – Comparative Studies on Endocrine Modulation in the Reproductive System of Invertebrates and Vertebrates

Watermann¹,

Gnass²,

Kolodzey³

et al. 2011

Pesticides in the Modern World - Effects of Pesticides Exposure

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Section: Introductionmentioning

confidence: 99%

“…The rodent thyroid/ pubertal assay using juvenile male rats is used to examine the effects of hormone-like acting substances on the neuroendocrine axis during the sensitive period of puberty. This assay has been used for evaluation of so-called endocrine disrupting chemicals, with several modifications [22][23][24][25][26][27].In vivo, estrogen controls many physiological processes and is involved in the development of reproductive organs. Recently, the effect of endogenous or exogenous chemicals with estrogenic activity on male reproductive development and function in adulthood has become the subject of intensive research and debate.…”

mentioning

confidence: 99%

Effects of Postnatal Administration of Diethylstilbestrol on Puberty and Thyroid Function in Male Rats

Shin

Kim

Kang

et al. 2009

Journal of Reproduction and Development

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Abstract.To examine the effects of diethylstilbestrol (DES) on male pubertal development and thyroid function, juvenile male Sprague-Dawley rats were given DES daily by oral intubation at doses of 10, 20 and 40 μg/kg/day from postnatal day 33 for 20 days. Prepuce separation was significantly delayed at the dose of 20 μg/kg/day and above in the DES-treated rats. DES treatment induced a significant reduction in the weights of testes, epididymides, the ventral prostate, seminal vesicles plus coagulating glands and fluid, levator ani bulbocavernosus muscles, Cowper's glands and the glans penis. The weights of the liver and adrenals increased in the DES-treated animals. DES caused a dosedependent reduction in germ cells; in particular the spermatids were mainly affected. The serum levels of testosterone and luteinizing hormone were significantly reduced in the DES-treated groups, but that of estradiol decreased. No differences were observed in the serum thyroxine levels of the control and DES-treated groups. In microscopic observation of the DES-treated animals, degeneration of germ cells and tubular atrophy in the testis were noted, but there were no microscopic changes in the thyroid. These results indicate that DES affected the pubertal development of juvenile male rats and that its mode of action may be related to alterations in hormone levels. Key words: Diethylstilbestrol, Male rat, Pubertal development (J. Reprod. Dev. 55: [461][462][463][464][465][466] 2009) oncerns have been raised about the potential adverse effects of environment chemicals that mimic the actions of estrogen on the reproduction and development of humans and wildlife species. Exposure of the developing male to exogenous estrogenic compounds can result in reproductive and developmental abnormalities and an increase in human male reproductive disorders, which include testicular cancer, cryptorchidism, hypospadias and low sperm counts [1][2][3][4]. Neonatal treatment with estrogens causes alterations in germ cell development and permanent impairment of testicular function [5][6][7][8][9]. As perinatal exposure of male animals and humans to synthetic estrogens can induce similar adverse changes in male reproductive health, it has been hypothesized that inappropriate exposure to estrogens during juvenile periods may interfere with the development of the reproductive system and with the sperm count in the adult [10,11]. Faced with growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influences of these substances on mammalian sexual differentiation and genital development [12,13].Diethylstilbestrol (DES) is a stilbene, a non-steroid estrogen, that can bind to estrogen receptors (ERs) and is widely used as a model estrogen for the study of estrogenic effects on the male reproductive function [13][14][15][16]. DES has been observed to have endocrine and reproductive toxicity in rats and mice. It is active over a wide dose range, showing effects on the mouse ventral prost...

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“…TBTO has been shown to be an endocrinedisrupting agent and to produce adverse effects in reproductive systems in aquatic organisms (Funahashi et al, 1980;Grote et al, 2004). Moreover, TBTO is known to persist in the environment with deleterious consequences to marine and aquatic ecosystems (Takashi et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO)

Osman¹,

Kol²,

Peijnenburg³

et al. 2009

Journal of Immunotoxicology

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Effects of organotin compounds on pubertal male rats

Cited by 102 publications

References 70 publications

Laboratory Tests with Androgenic and Anti-Androgenic Pesticides – Comparative Studies on Endocrine Modulation in the Reproductive System of Invertebrates and Vertebrates

Laboratory Tests with Androgenic and Anti-Androgenic Pesticides – Comparative Studies on Endocrine Modulation in the Reproductive System of Invertebrates and Vertebrates

Effects of Postnatal Administration of Diethylstilbestrol on Puberty and Thyroid Function in Male Rats

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO)

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