2021
DOI: 10.1016/j.jmgm.2020.107799
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Effects of oscillating electric fields on conotoxin peptide conformation: A molecular dynamic simulation study

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Cited by 11 publications
(7 citation statements)
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“…Dean et al simulated the M-1 conotoxin protein under the oscillating electric fields of strengths 2, 6, and 47 V/m at the frequency of 1800 MHz. 14 The results showed that the conformation of the toxin changed at 47 V/m electric field, but changed very little at 6 V/m electric field, and the lowest electric field of 2 V/m had no effect on the conformation of the toxin. Cifra and Prusǎ analyzed the influence of the parameters of molecular force field on dielectric spectrum.…”
Section: Introductionmentioning
confidence: 93%
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“…Dean et al simulated the M-1 conotoxin protein under the oscillating electric fields of strengths 2, 6, and 47 V/m at the frequency of 1800 MHz. 14 The results showed that the conformation of the toxin changed at 47 V/m electric field, but changed very little at 6 V/m electric field, and the lowest electric field of 2 V/m had no effect on the conformation of the toxin. Cifra and Prusǎ analyzed the influence of the parameters of molecular force field on dielectric spectrum.…”
Section: Introductionmentioning
confidence: 93%
“…The molecular mechanism of the nonthermal effect of microwaves has been studied deeply. Yarovsky et al used molecular dynamics simulation to study the structure, side-chain orientation, aggregation tendency, and dipole moment orientation of polypeptides in a microwave field . The results showed that different intensities and frequencies of the microwave field induced specific polypeptide structure.…”
Section: Introductionmentioning
confidence: 99%
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“…By stimulating proteases according to this property to change their secondary structure and, thus, affect the function or properties of proteases, the catalytic process can be precisely controlled to achieve the goals of clinical precision treatment and maximizing production benefits. Many factors affect the structure of proteins, and a large number of studies have shown that exogenous factors such as pressure [8], temperature [9][10][11], ion concentration [11], irradiation [12], PH [13], the electric field [14][15][16], and magnetic field [17] affect protein conformation stability.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, the focus of neurodegenerative disease research has been shifted towards the molecular level: on the effects of electric field on protein conformation, aggregation, and fibril formation. It has already been shown that different electric field modalities, such as oscillating [ 30 , 31 ] and static fields [ 32 , 33 ] can induce significant structural changes in amylogenic proteins [ 34 , 35 ] and disrupt aggregations and fibrils [ 36 ]. Studies also report electric field-induced changes in activity [ 37 , 38 ], hydration [ 39 ], and adsorption [ 40 ] of proteins.…”
Section: Introductionmentioning
confidence: 99%