Effects of osteoporosis on alveolar bone repair after tooth extraction: A systematic review of preclinical studies

Só, Bruna Barcelos; Silveira, Felipe Martins; Llantada, Gabriela Sauer; Jardim, Luísa Comerlato; Calcagnotto, Thiago; Martins, Marco Antônio Trevizani; Martins, Manoela Domingues

doi:10.1016/j.archoralbio.2021.105054

Cited by 11 publications

(9 citation statements)

References 80 publications

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“…Owing to the high ROS level and persistent inflammation throughout the entire bone repair cycle, the osteoclast activity surpasses osteoblast activity, resulting in delayed bone regeneration . Consequently, effective antioxidant and anti-inflammatory treatments throughout the bone repair cycle (>3 months) are necessary for osteoporotic bone implants. , Before the antioxidant and anti-inflammatory experiments began, the LA released from the hydrogels was determined as a function of time by measuring the LA content in the extracts. As shown in Figure b, the concentration of LA gradually decreased over time, yet it still exceeded 1000 μM after 3 months of release, so it had the potential for treating long-term disease.…”

Section: Resultsmentioning

confidence: 99%

Degradation-Dependent Self-Release Hydrogel with over Three Months of Antioxidation and Anti-inflammation for Osteoporotic Bone Repair

Zhou,

Lu,

Jia

et al. 2024

Chem. Mater.

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Although hydrogel-loaded drugs hold potential for treating osteoporotic bone defects, there is no example that meets the release requirement for repair of >3 months owing to the difficulty in overcoming the diffusion drug release. Herein, a degradation-dependent self-release (DDSR) hydrogel that negated diffusion was developed by polymerizing only the natural antioxidant lipoic acid (LA). By controlling just the degradation rate of the hydrogel, the LA sustained release from the poly(LA) backbone and achieved ∼4 months of antioxidation and anti-inflammation. After 12 weeks of implantation, the new bone formation ratio in osteoporotic bone defects treated using the DDSR hydrogel ran to 46 ± 5.7%, considerably higher than that of untreated defects (25.4 ± 4.2%) and even approaching that of normal bone repair (48.7 ± 7.1%). Notably, the DDSR hydrogel could also serve as carriers to load osteoinductive nanohydroxyapatite, thus further accelerating osteoporotic bone repair. The DDSR hydrogel with no diffusion constitutes the first hydrogel of >3-month drug release for osteoporotic bone repair.

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Section: Resultsmentioning

confidence: 99%

Degradation-Dependent Self-Release Hydrogel with over Three Months of Antioxidation and Anti-inflammation for Osteoporotic Bone Repair

Zhou,

Lu,

Jia

et al. 2024

Chem. Mater.

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“…Densidad ósea en la mandíbula: La osteoporosis puede afectar el hueso de la mandíbula, lo que representa desafíos durante procedimientos dentales como la colocación de implantes y cirugía oral (5,15). La disminución de la DMO en la mandíbula conlleva cambios microestructurales, como mayor porosidad y pérdida de densidad trabecular, predisponiendo a microfracturas.…”

Section: Impacto En La Salud Oralunclassified

“…Los resultados resaltaron que la LSI, mediante la relación de contraste de speckle y la relación de parches, permitió diferenciar entre tejido sano y osteoporótico. Estos hallazgos sugieren que la LSI podría ser útil para evaluar lesiones de osteoporosis en el hueso alveolar (15).…”

Section: Técnica De Imágenes De Speckle Láser (Lsi)unclassified

Osteoporosis de los huesos maxilares

Vaca Navarrete,

Mendoza Arteaga,

Granizo Molina

et al. 2024

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Introducción: La osteoporosis es una enfermedad que debilita los huesos y aumenta el riesgo de fracturas. Afecta a millones de personas en todo el mundo y se espera que su incidencia se duplique. Se relaciona con la salud oral, especialmente la densidad ósea mandibular, evaluada mediante radiografías panorámicas y el Índice Cortical Mandibular (ICM). La densitometría ósea (DXA) es crucial para el diagnóstico. El tratamiento requiere un enfoque integral para el cuidado del paciente. Objeto: sintetizar los principales tópicos respecto a osteoporosis de los maxilares, para proporcionar una comprensión integral del impacto de esta condición en la salud oral. Metodología: Se realizó una revisión bibliográfica narrativa a partir de una búsqueda de artículos científicos en las bases de especializadas ScienceDirect, SciELO, Redalyc, PubMed. Los criterios de selección para la construcción del manuscrito son: artículos en inglés y/o español que incluyeran información respecto a la fisiopatología, etiología, características, diagnóstico y abordaje terapéutico de la osteoporosis y su relación con la salud bucal. Resultados: Se construyó un documento científico accesible para el personal de primer nivel que aborda a este grupo de pacientes. Conclusión: La osteoporosis generalmente no afecta significativamente a los huesos orofaciales, pero puede provocar complicaciones dentales y maxilofaciales. La enfermedad periodontal es más común y grave en personas con osteoporosis, debido a la pérdida de densidad ósea. Es esencial que los pacientes con osteoporosis reciban atención dental regular y se comuniquen con su dentista sobre su condición. Un seguimiento dental regular es importante para detectar y tratar problemas tempranos. Los dentistas deben trabajar con otros médicos para cuidar adecuadamente a los pacientes con osteoporosis y prevenir complicaciones dentales y maxilofaciales. Área de estudio general: odontología. Área de estudio específica: rehabilitación oral. Tipo de estudio: original.

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“…OVX females (OVXF) received an ovariectomy at 12 weeks of age followed by 14 weeks of healing, similar to an established model performed by Du et al [65]. Removal of ovaries creates conditions for estrogen deficiency-induced osteoporosis, similar to human menopause, resulting in a dysregulation of bone remodeling [65,66]. The OM group was chosen to simulate the detrimental effects of senescence on bone remodeling.…”

Section: Animalsmentioning

confidence: 99%

Effects of Dicationic Imidazolium-Based Ionic Liquid Coatings on Oral Osseointegration of Titanium Implants: A Biocompatibility Study in Multiple Rat Demographics

Wheelis

Biguetti

Natarajan

et al. 2022

Genes

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Dicationic imidazolium-based ionic liquids with amino acid anions, such as IonL-phenylalanine (IonL-Phe), have been proposed as a multifunctional coating for titanium (Ti) dental implants. However, there has been no evaluation of the biocompatibility of these Ti coatings in the oral environment. This study aims to evaluate the effects of IonL-Phe on early healing and osseointegration of Ti in multiple rat demographics. IonL-Phe-coated and uncoated Ti screws were implanted into four demographic groups of rats to represent biological variations that could affect healing: young males (YMs) and females (YFs), ovariectomized (OVXFs) females, and old males (OMs). Samples underwent histopathological and histomorphometric analysis to evaluate healing at 7 and 30 days around IonL-coated and uncoated Ti. The real-time quantitative polymerase chain reaction was also conducted at the 2- and 7-day YM groups to evaluate molecular dynamics of healing while the IonL-Phe was present on the surface. IonL-coated and uncoated implants demonstrated similar histological signs of healing, while coated samples’ differential gene expression of immunological and bone markers was compared with uncoated implants at 2 and 7 days in YMs. While YMs presented suitable osseointegration for both uncoated and IonL-Phe-coated groups, decreased success rate in other demographics resulted from lack of supporting bone in YFs and poor bone quality in OVXFs and OMs. Overall, it was found that IonL-coated samples had increased bone-to-implant contact across all demographic groups. IonL-Phe coating led to successful osseointegration across all animal demographics and presented the potential to prevent failures in scenarios known to be challenged by bacteria.

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Effects of osteoporosis on alveolar bone repair after tooth extraction: A systematic review of preclinical studies

Cited by 11 publications

References 80 publications

Degradation-Dependent Self-Release Hydrogel with over Three Months of Antioxidation and Anti-inflammation for Osteoporotic Bone Repair

Degradation-Dependent Self-Release Hydrogel with over Three Months of Antioxidation and Anti-inflammation for Osteoporotic Bone Repair

Osteoporosis de los huesos maxilares

Effects of Dicationic Imidazolium-Based Ionic Liquid Coatings on Oral Osseointegration of Titanium Implants: A Biocompatibility Study in Multiple Rat Demographics

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