Effects of ovariectomy and estrogen replacement therapy on arthritis and bone mineral density in rats with collagen-induced arthritis

Yamasaki, Daisuke; Enokida, Makoto; Okano, T.; Hagino, Hiroshi; Teshima, Ryota

doi:10.1016/s8756-3282(01)00426-4

Cited by 39 publications

(42 citation statements)

References 28 publications

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“…Therefore, glucocorticoids are widely used to treat a variety of inflammatory diseases, such as asthma, rheumatoid arthritis and inflammatory bowel disease (IBD) (Franchimont, 2004). Furthermore, estrogen is used to prevent postmenopausal osteoporosis and also relieves symptoms in animal models of atherosclerosis, rheumatoid arthritis and IBD (Yamasaki et al, 2001;Pfeilschifter et al, 2002;Hodgin and Maeda, 2002;Chadwick et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Direct interaction between estrogen receptor α and NF-κB in the nucleus of living cells

Quaedackers

Brink

Saag

et al. 2007

Molecular and Cellular Endocrinology

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Section: Introductionmentioning

confidence: 99%

Direct interaction between estrogen receptor α and NF-κB in the nucleus of living cells

Quaedackers

Brink

Saag

et al. 2007

Molecular and Cellular Endocrinology

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“…The peak incidence in women coincides with the time of menopause (2), and there is evidence that the female sex hormone estrogen can affect both the incidence and the progression of the disease in humans (3,4) and in animal models (5)(6)(7). The disease activity often decreases during pregnancy (4) and then flares in the postpartum period, when hormone levels drop quickly.…”

mentioning

confidence: 99%

“…The frequency of generalized osteoporosis in postmenopausal patients with RA has been reported to be almost 50% (9,10). Collagen-induced arthritis (CIA) is a well-established mouse model of human RA (11), and the impact of sex steroids on the inflammatory disease has been extensively studied by several groups (5)(6)(7)12,13). We have recently reported that both the estrogen deficiency after ovariectomy and the inflammatory disease contribute equally and additively to the development of generalized bone loss in CIA (14).…”

mentioning

confidence: 99%

Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis

Jochéms

Islander

Kallkopf

et al. 2007

Arthritis & Rheumatism

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Objective. In postmenopausal rheumatoid arthritis (RA), both estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. Hormone replacement therapy (HRT) with estradiol preserves bone mineral density (BMD) and ameliorates arthritis, but long-term therapy is no longer an option due to significant side effects. We therefore used a mouse model of human RA to test the hypothesis that a selective estrogen receptor modulator (SERM), the raloxifene analog LY117018, could be beneficial in the treatment of both arthritis and osteoporosis.Methods. Female DBA/1 mice were ovariectomized and arthritis was induced with collagen immunization. Mice received an injection of raloxifene, estradiol, or vehicle control, administered prophylactically or therapeutically, and thereafter the clinical arthritis score was evaluated continuously. At termination, BMD was analyzed with peripheral quantitative computed tomography. Paws were collected for histology, and sera were analyzed for cytokines and markers of bone and cartilage turnover. Levels of cytokine messenger RNA (mRNA) were investigated with real-time polymerase chain reaction.Results. Treatment with raloxifene dramatically decreased the frequency and severity of arthritis. Effective preservation of bone and cartilage was seen in raloxifene-exposed mice, as demonstrated by increased BMD and decreased serum levels of cartilage oligomeric matrix protein in the raloxifene-treated mice compared with controls. Decreased levels of mRNA for both tumor necrosis factor ␣ and RANKL in spleen cells from raloxifene-treated arthritic mice indicated an immunosuppressive action of this SERM.Conclusion. In a well-established model of postmenopausal RA, the raloxifene analog LY117018 potently inhibits the progression of arthritis and the associated development of osteoporosis, both in a prophylactic and in a therapeutic regimen. Since long-term HRT has been associated with significant side effects, raloxifene may be a useful adjuvant treatment for postmenopausal RA.

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“…The joint diameter was measured in millimeters with the help of Vernier calipers, and change in joint diameter was calculated (21,22).…”

Section: Pharmacological Studymentioning

confidence: 99%

Reduced Ulcerogenic Potential and Antiarthritic Effect of Chitosan–Naproxen Sodium Complexes

Ghosh

Bhise²,

Paradkar

et al. 2012

AAPS PharmSciTech

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Abstract. The purpose of this research was to address the utility of naproxen sodium-chitosan spray-dried complexes for antiulcer and antiarthritic activities. The cold stress technique was used to examine the ulcerogenic potential of naproxen sodium (NPX) and spray-dried formulations in the different doses. The ulcerations reduced with the dose of spray-dried complexes of naproxen sodium and chitosan. The conspicuous hemorrhagic lesions were visible in the morphological features of the animal treated with naproxen 50 mg/kg (p.o.). Thus, the results suggest that the spray-dried naproxen sodium-chitosan complex (NPXF) was not corrosive to the gastric mucosa at high doses of 50, 100, and 200 mg/kg (p.o.) under stressful conditions. It is evident from the present investigation that NPXF does not possess any ulcerogenic potential in comparison to naproxen which, under stressful conditions, led to the hypersecretion of HCl, culminating to petichial hemorrhages in the gastric mucosa of the animals. The biphasic pattern was observed in the various arthritic parameters. The rise in paw volume, joint diameter, WBC count, arthritis score, and fall in body weight was significantly ameliorated in the animals treated with NPXF (5, 10, and 20 mg/kg, p.o). At the end of the study, slight erythema was visible in the naproxen-treated animals. However, no erythema, redness, or ulcers were visible in the animals treated with NPXF. Thus, the direct compression properties and reduced ulcerogenic activity, combined with the demonstrated solubilizing power and analgesic effect enhancer ability toward the drug, make naproxen sodium-chitosan spray-dried complexes particularly suitable for developing a reduced-dose, fast-release, solid oral dosage form of naproxen.

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Effects of ovariectomy and estrogen replacement therapy on arthritis and bone mineral density in rats with collagen-induced arthritis

Cited by 39 publications

References 28 publications

Direct interaction between estrogen receptor α and NF-κB in the nucleus of living cells

Direct interaction between estrogen receptor α and NF-κB in the nucleus of living cells

Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis

Reduced Ulcerogenic Potential and Antiarthritic Effect of Chitosan–Naproxen Sodium Complexes

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