Effects of Ovariectomy and Exercise Training on Mineral Status in a High-Fat Diet-Induced Obesity Rat Model

Mašánová, Vlasta; Krivošíková, Zora; Ursı́nyová, Monika; Uhnáková, Iveta; Kebis, Anton; Kramárová, Patrícia; Wsólová, Ladislava; Gajdoš, Martin

doi:10.1007/s12011-021-02655-9

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…Considering that physical exercise increases energy expenditure [42], it is possible to speculate that the trained OVX animals presented a negative energy balance, leading to the protective effects of training on weight and fat gain. These data corroborate other studies that also showed a reduction in body weight [36,43] and adiposity [44] after physical training sessions with OVX rodents.…”

Section: Discussionsupporting

confidence: 92%

Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis

Santos,

Silva,

Alves

et al. 2024

IJMS

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Menopause is characterized by a reduction in sex hormones in women and is associated with metabolic changes, including fatty liver and insulin resistance. Lifestyle changes, including a balanced diet and physical exercise, are necessary to prevent these undesirable changes. Strength training (ST) has been widely used because of the muscle and metabolic benefits it provides. Our study aims to evaluate the effects of ST on hepatic steatosis and insulin resistance in ovariectomized mice fed a high-fat diet (HFD) divided into four groups as follows: simulated sedentary surgery (SHAM-SED), trained simulated surgery (SHAM-EXE), sedentary ovariectomy (OVX-SED), and trained ovariectomy (OVX-EXE). They were fed an HFD for 9 weeks. ST was performed thrice a week. ST efficiently reduced body weight and fat percentage and increased lean mass in OVX mice. Furthermore, ST reduced the accumulation of ectopic hepatic lipids, increased AMPK phosphorylation, and inhibited the de novo lipogenesis pathway. OVX-EXE mice also showed a better glycemic profile, associated with greater insulin sensitivity identified by the euglycemic–hyperinsulinemic clamp, and reduced markers of hepatic oxidative stress compared with sedentary animals. Our data support the idea that ST can be indicated as a non-pharmacological treatment approach to mitigate metabolic changes resulting from menopause.

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Section: Discussionsupporting

confidence: 92%

Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis

Santos,

Silva,

Alves

et al. 2024

IJMS

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show abstract

“…Conversely, in obese rats induced by a HFD, adipose tissue increases in the bone marrow, and the microarchitecture is destroyed. [ 27 ] Various inflammatory cytokines derived from adipocytes negatively affect the bone,[ 28 ] which was supported by our current results. The tissue volume was the smallest in the control group with the smallest body weight, and the tissue volume was the largest in the HFD group with the largest body weight.…”

Section: Discussionsupporting

confidence: 87%

“…4A ). According to a previous study by Masanova et al[ 28 ], a HFD interferes with mineral deposition in bone. Even if a bone structure is eventually formed by osteoblasts, bone strength cannot be maintained if the mineralization process is not performed well and will result in a condition similar to that of osteomalacia or rickets.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Protects Bone Microarchitecture against Deterioration due to High-Fat Diet-Induced Obesity

Kim

et al. 2023

J Bone Metab

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Background: We evaluated the protective effects of melatonin against high-fat diet (HFD)-induced deterioration of bone microarchitecture using high-resolution peripheral quantitative computed tomography (HR-pQCT).Methods: Four-week-old male C57BL/6 mice were divided into control (chow diet group), HFD, and HFD + melatonin-administered groups. Mice were sacrificed after 14 weeks, and the right femur was extracted. The microskeletal structure of the femur was analyzed using SkyScan1173 (version 1.6). A 3-dimensional image was reconstructed using the Nrecon (version 1.7.0.4) program.Results: Bone volume (BV) was significantly increased in the HFD group compared with that in the normal diet group, and that of the melatonin group also increased significantly compared with BV of the normal diet group (<i>p</i><0.05). Percent BV/total volume [TV] and bone surface/BV were significantly higher in both the HFD and melatonin groups than in the normal diet group (<i>p</i><0.05), and the melatonin group had the highest BV/total volume (TV). BMD was lower in the HFD than in the normal diet group and was the highest in the melatonin group.Conclusions: This study shows that melatonin inhibited the deterioration of microarchitecture induced by a HFD. A better understanding of the protective effect of melatonin on bone microarchitecture and mechanisms could provide fracture prevention for people who are obese.

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“…Zn 2+ also inhibits the expression of RANKL in osteoblasts and inhibits the formation of osteoclasts. 76,77 Studies have shown that when Zn 2+ contacts osteoblasts, it stimulates the production of TGF-b, which can increase the production of OPG to inhibit osteoclast activity. 78 Additionally, Ca 2+ and Sr 2+ can also inhibit osteoclasts to promote bone tissue growth.…”

Section: Inhibition Of Osteoclastsmentioning

confidence: 99%

Application of bioactive metal ions in the treatment of bone defects

Cui

et al. 2022

J. Mater. Chem. B

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Effects of Ovariectomy and Exercise Training on Mineral Status in a High-Fat Diet-Induced Obesity Rat Model

Cited by 5 publications

References 57 publications

Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis

Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis

Melatonin Protects Bone Microarchitecture against Deterioration due to High-Fat Diet-Induced Obesity

Application of bioactive metal ions in the treatment of bone defects

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