2020
DOI: 10.3390/ijms21082661
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Effects of Oxidative Stress on Protein Translation: Implications for Cardiovascular Diseases

Abstract: Cardiovascular diseases (CVDs) are a group of disorders that affect the heart and blood vessels. Due to their multifactorial nature and wide variation, CVDs are the leading cause of death worldwide. Understanding the molecular alterations leading to the development of heart and vessel pathologies is crucial for successfully treating and preventing CVDs. One of the causative factors of CVD etiology and progression is acute oxidative stress, a toxic condition characterized by elevated intracellular levels of rea… Show more

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Cited by 51 publications
(41 citation statements)
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References 195 publications
(221 reference statements)
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“…The regulation of protein synthesis under oxidative conditions can vary depending on the concentration of ROS. It is known that under a low or medium concentration of ROS, the translation process of certain proteins, such as the antioxidant transcription factor Nrf2, may be induced for adaptation to the oxidative microenvironment [ 19 , 76 ], while high concentrations of ROS completely damage this process [ 79 ]. Moreover, data from the literature indicate that the polyadenylate-binding protein 1 may play a role in mRNA stability [ 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…The regulation of protein synthesis under oxidative conditions can vary depending on the concentration of ROS. It is known that under a low or medium concentration of ROS, the translation process of certain proteins, such as the antioxidant transcription factor Nrf2, may be induced for adaptation to the oxidative microenvironment [ 19 , 76 ], while high concentrations of ROS completely damage this process [ 79 ]. Moreover, data from the literature indicate that the polyadenylate-binding protein 1 may play a role in mRNA stability [ 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…In addition to cancer, several neurodegenerative diseases, such as the commonly known Parkinson’s disease and Alzheimer’s disease, have also been linked to oxidative stress [ 48 , 49 ]. Besides, oxidative stress is involved in the pathogenesis of many other diseases as well, either chronic or acute, which include cardiovascular diseases [ 50 , 51 ], insulin resistance [ 52 ], pulmonary fibrosis [ 53 , 54 ], chronic obstructive pulmonary disease (COPD) [ 55 ], muscle protein degradation [ 56 ], renal dysfunction [ 57 ], stroke and others [ 58 ].…”
Section: Oxidative Stressmentioning
confidence: 99%
“…Importantly, we show that the SAC defect observed in Aurkb cKO oocytes can be explained by an age‐related reduction in the expression of key SAC proteins. Because oxidative stress (OS), another hallmark of maternal gamete aging (Tarín, 1995), can alter protein homeostasis (Ghosh & Shcherbik, 2020; Stadtman & Levine, 2000), we evaluated reactive oxygen species (ROS) accumulation in cKO oocytes. We observed premature accumulation of ROS in older Aurkb cKO prophase I‐arrested oocytes when compared to oocytes from wild‐type (WT) animals, consistent with an alteration in protein homeostasis.…”
Section: Introductionmentioning
confidence: 99%