Effects of Oxidative Stress on the Electrophysiological Function of Neuronal Membranes

Jovanović, Zorica

doi:10.5772/33580

Cited by 1 publication

(1 citation statement)

References 86 publications

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“…A decrease in the level of CoQ10, the only endogenously produced lipid-soluble antioxidant produced in the cell [28], with ageing has been shown [31]. As discussed previously, ROS may compromise the integrity of cell membranes via peroxidation of membrane lipids [32,33], which impacts mechanical properties of cell membrane.…”

Section: Discussionmentioning

confidence: 91%

Significance of Ubiad1 for Epidermal Keratinocytes Involves More Than CoQ10 Synthesis: Implications for Skin Aging

et al. 2018

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Abstract:The significance of Coenzyme Q10 (CoQ10) as an anti-oxidant barrier of the skin, as well as a key component in anti-aging strategies for skin care products, has been firmly established. Biosynthesis of CoQ10 in the mitochondria is well known, but there is only limited information on the non-mitochondrial synthesis of CoQ10 in the skin. Recent findings in zebrafish identified that a tumor suppressor, Ubiad1, is also a key enzyme in the non-mitochondrial synthesis of CoQ10. The purpose of this study was to investigate expression of Ubiad1 in human skin, and its implication in the skin's cutaneous response to oxidative stress. We observed Ubiad1 localization in the epidermis, particularly a subcellular localization in the Golgi apparatus. Ubiad1 modulation by a pentapeptide was associated with an observed reduction in ROS/RNS stresses (−44%/−19% respectively), lipid peroxidation (−25%) and preservation of membrane fluidity under stress conditions. Electron microscopy of keratinocytes revealed a significant degree of stimulation of the Golgi complex, as well as significantly improved mitochondrial morphology. Given the importance of CoQ10 in mitigating the visible signs of skin aging, our findings identify Ubiad1 as an essential component of the defensive barriers of the epidermis.

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