Effects of Oxygen and Carbon Dioxide on Inosine Fermentation

Shibai, Hiroshiro; Ishizaki, Ayaaki; Mizuno, Hiroshi; Hirose, Yoshio

doi:10.1080/00021369.1973.10860642

Cited by 14 publications

(6 citation statements)

References 2 publications

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“…lactofermenturn high partial pressures of CO, caused a decrease in glutamate production, sugar consumption and respiratory activity (Hirose et al 1968). High CO, tension also resulted in a decrease in product formation in a nucleoside fermentation employing a mutant of B. subtilis (Shibai et al 1973). In the same fermentation, the yield of inosine was shown to be independent of the bicarbonate ion concentration in the culture medium, but greatly reduced by increasing partial pressures of CO, (Ishizaki et al 1973).…”

Section: Effects O F C O O N T H E P R O D U C T I O N O F B I O C mentioning

confidence: 96%

The inhibition by CO₂ of the growth and metabolism of micro‐organisms

Dixon

Kell

1989

Journal of Applied Bacteriology

437

244

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Section: Effects O F C O O N T H E P R O D U C T I O N O F B I O C mentioning

confidence: 96%

The inhibition by CO₂ of the growth and metabolism of micro‐organisms

Dixon

Kell

1989

Journal of Applied Bacteriology

437

244

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“…Accumulation of evolved C02 in the fermentor head space and the culture medium can inhibit many microbial biosynthetic processes (5,22,23,27,36). Problems associated with inadequate ventilation of evolved C02 are now being studied for industrial processes (18)(19)(20)(21).…”

Section: Resultsmentioning

confidence: 99%

Application of Oxygen-Enriched Aeration in the Production of Bacitracin by Bacillus licheniformis

Flickinger

Perlman

1979

Antimicrob Agents Chemother

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The physiological effects of controlling the dissolved oxygen tension at 0.01, 0.02, and 0.05 atm by the use of oxygen-enriched aeration were investigated during growth and bacitracin production by Bacillus licheniformis ATCC 10716. Up to a 2.35-fold increase in the final antibiotic yield and a 4-fold increase in the rate of bacitracin synthesis were observed in response to 02-enriched aeration. The increase in antibiotic production was accompanied by increased respiratory activity and an increase in the specific productivity of the culture from 1.3 to 3.6 g of antibiotic per g of cell mass produced. Oxygen enrichment of the aeration decreased medium carbohydrate uptake and the maximum specific growth rate of B. licheniformis from 0.6 h-1 to as low as 0.15 h-', depending upon the level of enrichment and the conditions of oxygen transfer rate (impeller speed). The response of this culture to 02 enrichment suggests that this method of controlling the dissolved oxygen tension for antibiotic-producing cultures may simulate conditions that would occur if the carbon source were fed slowly, as is often employed to optimize antibiotic production. Analysis of the biologically active bacitracins produced by B. licheniformis ATCC 10716 suggested that the ratio of biologically active peptides was not changed by 02 enrichment, nor were any new biologically active compounds formed.

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“…The microorganism, medium, analytical procedures and instruments for carbon dioxide and oxygen detec tion were the same as described in the previous papers. 1,9) Fermentation was carried out by glass made jar fer mentors with 400ml of the medium and stainless steel jar fermentors of a total volume of 70liters containing 30liters of the medium.…”

Section: Methodsmentioning

confidence: 99%