Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio)

Oliveira, Rhaul; McDonough, Sakchai; Ladewig, Jessica Cl; Soares, Amadeu M.V.M.; Nogueira, António J.A.; Domingues, Inês

doi:10.1016/j.etap.2013.07.019

Cited by 142 publications

(79 citation statements)

References 43 publications

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“…In freshwater microalga ( Scenedesmus obliquus ) exposed to norfloxacin in the concentration range between 0.0 and 60 mg L −1 , GST activity was found to be significantly increased at higher norfloxacin concentrations, reaching a peak value at 15 mg L −1 [21]. Oliveira et al [28] investigated the effect of two antibiotics (oxytetracycline and amoxicillin) on zebrafish enzymes. GST activity was induced in muscle and gill samples.…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Oliveira et al, amoxicillin at the highest concentration (221 mg L −1 ) inhibited the activity of CAT in gills and head samples of zebrafish. Zebrafish exposed to oxytetracycline in the concentration of 25.0–100.0 mg L −1 exhibited a dose-dependent inhibition of CAT activity in head samples, whereas no alteration was observed in the other tissues analyzed [28]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Bartoskova

Dobšíková

Stancová

et al. 2014

BioMed Research International

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The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215. In the Subchronic Toxicity Test, a significant (P < 0.01) increase in the activity of glutathione peroxidase, glutathione S-transferase, and catalase was found. In the test, norfloxacin did not affect lipid peroxidation and catalytic activity of glutathione reductase. From the results, we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Bartoskova

Dobšíková

Stancová

et al. 2014

BioMed Research International

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“…Furthermore, in 2013 at the University of Aveiro Portugal, Oliveira et al, measured the effects of amoxicillin in embryos and adults of Danio rerio; the effects found in embryos exposed with amoxicillin were premature hatching, malformations such as edema and deformities in the tail as well as abnormal development of fish. In the other hand, in adults exposed to amoxicillin, they found that amoxicillin produce the inhibition on the activity of the enzyme catalase (CAT) in certain tissues such as gills and brain, as well as produce an induction of the activity of the enzyme glutathione transferase (GTS) in tissues such as muscle, gills and brain, indicating that this antibiotic is capable of modifying the normal enzyme activity in fish [118].…”

Section: Toxicological Risk Of Amoxicillinmentioning

confidence: 99%

Amoxicillin in the Aquatic Environment, Its Fate and Environmental Risk

Elizalde-Velázquez¹,

Gómez-Oliván²,

Galár-Martínez³

et al. 2016

Environmental Health Risk - Hazardous Factors to Living Species

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Amoxicillin is a broad-spectrum antibiotic widely used for treating both human and animal diseases, and it belongs to a group that are excreted unchanged within urine and faeces; therefore, it is possible to find traces of this drug or its degradation products in environmental water bodies. In water, it is rapidly degraded by biotic and abiotic factors, yielding different intermediate products; these are suspected of being more resistant to degradation, and potentially more toxic, than the parent compound. In the water bodies, these compounds may produce toxic effects on the aquatic organisms from different trophic levels and produce an ecological imbalance. Amoxicillin may bioaccumulate in fish muscle tissues, with the possibility of the occurrence of these drugs in food, leading to a passive consumption of this antibiotic resulting in undesirable effects on consumer health such as immunoallergic responses. However, the main problem related with the presence of this antimicrobial compounds in fish tissues is the possibility of inducing bacterial resistance genes. At present, the available scientific knowledge is less than what is needed to fully assess the risks that amoxicillin pose to the environment, and it is still necessary to conduct large amount of research works before a thorough understanding of this severe environmental issue.

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“…Oliveira et al [98] observed the inhibition of catalase activity in adult brain and gills of Danio rerio fish when exposed to higher concentrations of amoxicillin (50 and 100 mg L -1…”

Section: Antibiotic Effects On the Environmentmentioning

confidence: 99%

Veterinary Antibiotics in the Environment

Botelho¹,

Monteiro²,

LuizTornisielo³

2015

Emerging Pollutants in the Environment - Current and Further Implications

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In recent years, pharmaceutical pollution in the environment has been a great concern due to the potential effects on the human and animal health. Some of the most used classes such as antibiotics, which are used to prevent and treat bacterial infections and promote the growth of livestock, deserve to be highlighted since their intensive use has contaminated environmental matrices such as soil, water, sediment, plants, and animals with effects on the biota. To better understand the potential ecological risk of antibiotics in environments and to develop management strategies for these substances searching to reach the reduction of these compounds in aquatic systems, one of the most important steps is to determine the environmental concentrations of these compounds in the environments through analytical methods and evaluate their effects on the biota. The goal of this chapter is contribute with information about the effects of these compounds on the biota as well as its environmental behavior and bacterial resistance in additional to the main techniques for samples preparation and quantitative and confirmatory methods for its determination in the environment.

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Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio)

Cited by 142 publications

References 43 publications

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Amoxicillin in the Aquatic Environment, Its Fate and Environmental Risk

Veterinary Antibiotics in the Environment

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