Effects of oxytocin on the hair growth ability of dermal papilla cells

Abstract

Oxytocin (OXT) is a neuropeptide hormone termed “love hormone” produced and released during childbirth and lactation. It is also produced in response to skin stimulation (e.g., during hugging and massaging) and music therapy. The effects of OXT on various organs have been revealed in recent years; however, the relationship between hair follicles and OXT remains unclear. In this study, we examined the effects of OXT on dermal papilla (DP) cells that control hair growth by secreting growth/regression signals. Gene expression analysis revealed that DP signature markers were significantly upregulated in DP cells treated with OXT. In addition, we tested the hair growth-promoting effects of OXT using in vitro hair follicle organoids. OXT promoted the growth of hair peg-like sprouting by upregulating the expression of growth-promoting factors, including genes encoding vascular endothelial growth factor A (VEGFA). This study highlights the positive effects of OXT in hair follicles and may assist in the development of new treatments for alopecia.

Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation

“…5 B). In our previous study, oxytocin caused a 1.3-increase in the same assay 6 . These results suggest that cinnamic acid has almost the same level of hair growth-promoting effect as oxytocin.…”

“…The application of this approach to cells of human origin showed that immature hair shaft-like structures elongated in response to minoxidil, a typical hair growth-promoting agent 15 . In our previous study, we examined potential hair growth-promoting drug candidates using human hair follicloids and identified the effects of oxytocin on hair growth 6 . In the present study, we evaluated the effects of cinnamic acid (0, 50, 100 and 500 μg/mL) on hair follicles using human hair follicloids.…”

“…Recently, we reported oxytocin as a potential hair growth promoter 6 . The study demonstrated that oxytocin treatment upregulated hair growth-related genes in dermal papilla (DP) cells, thereby promoting hair growth in an in vitro hair follicle growth model.…”