Effects of paeoniflorin on tumor necrosis factor-α-induced insulin resistance and changes of adipokines in 3T3-L1 adipocytes

Periapical lesions decrease Akt serine phosphorylation and plasma membrane GLUT4 content in rat skeletal muscle

“…Conversely, attenuation of TNF-α-induced inflammation has been found to restore tyrosine phosphorylation of IRS-1 and Akt in 3T3-L1 adipocytes [30], suggesting that TNF-α directly affects Akt phosphorylation. Reduced plasma cytokine levels in patients undergoing apicoectomy, curettage [31,32], tooth extraction [33], or conventional endodontic therapy [34] indicate that treatment of inflammatory disorders such as PL can reverse systemic inflammation.…”

Paeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways

“…Thus, reduction of the microglial chemotaxis has been considered as a promising strategy for controlling AD development. Previous researches showing inhibitory effects of PF on CCL-2 in 3T3-L1 (Kong et al, 2013) and HT-29 (Zhang et al, 2014) cells promote us to investigate its effects on Aβ-stimulated CCL-2 production in microglia. We here found that PF administration decreased CCL-2 production from Aβ 1-42 -treated microglia.…”

Paeoniflorin inhibits doxorubicin-induced cardiomyocyte apoptosis by downregulating microRNA-1 expression

“…(family Paeoniaceae), which is a traditional Chinese herbal medicine that has been used in China for >1,000 years. It has been reported that PEF exerts multiple pharmacological activities, such as inhibition of tumor invasion and metastasis (15), reduction of inflammatory factor production (16), prevention of insulin resistance (17) and neuroprotective effects (18). Our previous study demonstrated that PEF was able to inhibit DOX-induced cardiomyocyte apoptosis by reducing the production of reactive oxygen species (ROS) (19); however, the downstream mechanism remains unclear.…”