Effects of pain and fatigue on physical functioning and depression in persons with muscular dystrophy

The association of age, pain, and fatigue with physical functioning and depressive symptoms in persons with spinal cord injury

“…[9][10][11][12][13]20,37 In the present study of persons with SCI, we observed similarities and differences in these associations relative to those observed in other populations. Specifically, pain -in addition to level of injury -was associated with physical functioning, and both pain and fatigue were associated with depression, highlighting the importance of monitoring both pain and fatigue as persons age with SCI.…”

“…walking more than a mile, doing vigorous activities). Relatedly, and also not surprising, participants' total scores on the PROMIS physical functioning measure were lower than we have observed for persons with other disabilities 20,37 (although not sufficiently low to create a floor effect). In fact, although not reported in this manuscript, we conducted the same analyses on versions of the PROMIS measure with additional items removed and also on other physical functioning measures from this survey and the results remained the same.…”

“…The findings of independent associations of pain and fatigue with depression closely mirror previous findings for SCI [9][10][11][12][13] and for other disabilities we have studied, such as post-polio syndrome 20 and muscular dystrophy. 37 By identifying independent associations of pain and fatigue with depression, the results demonstrate that pain and fatigue are not merely proxy measures of each other. Instead, they make independent contributions to depression, which suggests that both clinical issues should be carefully evaluated and treated so as to minimize their respective potential negative influences on depression.…”

Resilience Predicts Functional Outcomes in People Aging With Disability: A Longitudinal Investigation

“…[26][27][28][29] Study inclusion criteria included (1) being able to read and write English; (2) endorsing a diagnosis of MS, SCI, MD or PPS; and (3) being at least 18 years old. Participants learned about the study through a registry of previous research participants (68%) or via advertisements or word of mouth (32%).…”

Quality improvement in neurology

“…29,30 Untreated pain interferes with physical functioning and is associated with depression. 31,32 Nonpharmacologic and pharmacologic interventions are available to treat pain and improve attendant comorbidities.…”