EFFECTS OF PARA AMINOBENZOIC ACID AND THIOURACIL ON THYROID FUNCTION AND RESISTANCE TO LOW PRESSURES<sup>1</sup>

Gordon, Michael; Goldsmith, E. D.; Charipper, Harry A.

doi:10.1210/endo-37-4-223

Cited by 12 publications

(7 citation statements)

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“…Thiourea-treated tadpoles reach sizes not attained in normal development (13,16). The growth-promoting effect of prolactin in these animals is equally well documented (4)(5)(6)(7)(8).…”

Section: Discussionmentioning

confidence: 94%

“…Tadpoles treated with appropriate doses of this substance enter into metamorphic stasis and remain in this condition as long as the treatment continues. After its termination, such tadpoles promptly resume normal metamorphic changes, provided that the dosages of the goitrogen were not too high and the treatment not too long (12)(13)(14). Mter the onset of thiourea administration there is usually a short initial period with a slight but consistent acceleration of hind leg growth (15) which Iwasawa (14) referred to as a passing hyperthyroidism-like condition.…”

Section: Discussionmentioning

confidence: 99%

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Prolactin as a Goitrogenic Agent in Amphibia¹

Gona

1967

Endocrinology

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The nature of the inhibitory action of mammalian prolactin on the development of bullfrog tadpoles was investigated. Tadpoles injected ip with 20 jug of thyroxine (T 4 ) and 2 or 4 mg of ovine prolactin (NIH-P-S-7) underwent metamorphic changes in parallel with T 4 -injected controls. By contrast, tadpoles injected with 4 IU of bovine thyrotropic hormone (TSH) and either 4.0 or 0.4 mg of prolactin entered into developmental stasis after showing early signs of metamorphic climax, while TSH-injected controls completed the various metamorphic steps, including tail resorption. Histological examination of the thyroids of animals treated with both TSH and prolactin revealed an extremely high degree of hypertrophy and hyperplasia, with more pronounced depletion of the colloid than in TSH-injected controls. It is concluded that in these experiments prolactin acts at the level of the thyroid and that it has goitrogenic properties. (Endocrinology 8 1 : 748, 1967) P ROLACTIN appears to possess a great diversity of actions in different vertebrates aside from its well-known effects in mammals. For example, it elicits "waterdrive," or second metamorphosis, in the red eft stage of the common newt (1, 2). Another role concerns osmoregulation in fish (3). Excess growth in tadpoles carrying ectopic pituitary transplants was reported by Etkin and Lehrer (4), who postulated that this was the result of an increased rate of prolactin secretion by the ectopic pituitaries which are freed from the normally existing hypothalamic inhibition of prolactin release. Other investigations demonstrated that mammalian prolactin has a marked growth-promoting effect in tadpoles (5-8). Olivereau (9) reported a thyroid-stimulating effect of prolactin in eels and concluded that this hormone acts as a thyrotropin-releasing factor in these fish. More recently, it was found (10) that mammalian prolactin inhibits metamor-

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“…Thiourea-treated tadpoles reach sizes not attained in normal development (13,16). The growth-promoting effect of prolactin in these animals is equally well documented (4)(5)(6)(7)(8).…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Prolactin as a Goitrogenic Agent in Amphibia¹

Gona

1967

Endocrinology

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“…Thiouracil l owers the incidence of dietary cirrhosis of the liver in rats (71), increases the resistance to reduced barometric pressure (72), interferes with the estrous cycle and lowers the heart rate (74), and diminishes cardiac response to epinephrine in patients (75). Thiourea induces suprarenal cortical deficiency and a de creased liver glycogen (73) and interferes with the development of sea urchin eggs (76):…”

Section: The Thyroid and Thyrotropic Hormonesmentioning

confidence: 99%

Metabolic Functions of the Endocrine Glands

Lukens¹

1947

Annu. Rev. Physiol.

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“…Depression of the B.M.R. by PABA was first conclusively demonstrated by Gordon, Goldsmith, and Charipper (1945). Berman (1945) reported a favorable response to PABA in patients with Graves' disease.…”

mentioning

confidence: 94%

Differentiation of the Antithyroid Action of Thiouracil, Thiourea and Paba From Sulfonamides by Iodide Administration

Mackenzie

1947

Endocrinology

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EFFECTS OF PARA AMINOBENZOIC ACID AND THIOURACIL ON THYROID FUNCTION AND RESISTANCE TO LOW PRESSURES¹

Cited by 12 publications

References 0 publications

Prolactin as a Goitrogenic Agent in Amphibia¹

Prolactin as a Goitrogenic Agent in Amphibia¹

Metabolic Functions of the Endocrine Glands

Differentiation of the Antithyroid Action of Thiouracil, Thiourea and Paba From Sulfonamides by Iodide Administration

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EFFECTS OF PARA AMINOBENZOIC ACID AND THIOURACIL ON THYROID FUNCTION AND RESISTANCE TO LOW PRESSURES1

Cited by 12 publications

References 0 publications

Prolactin as a Goitrogenic Agent in Amphibia1

Prolactin as a Goitrogenic Agent in Amphibia1

Metabolic Functions of the Endocrine Glands

Differentiation of the Antithyroid Action of Thiouracil, Thiourea and Paba From Sulfonamides by Iodide Administration

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Product

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EFFECTS OF PARA AMINOBENZOIC ACID AND THIOURACIL ON THYROID FUNCTION AND RESISTANCE TO LOW PRESSURES¹

Prolactin as a Goitrogenic Agent in Amphibia¹

Prolactin as a Goitrogenic Agent in Amphibia¹