Effects of paracetamol on the polychaete Hediste diversicolor: occurrence of oxidative stress, cyclooxygenase inhibition and behavioural alterations

Nogueira, Ana Filipa; Nunes, Bruno

doi:10.1007/s11356-020-12046-7

Cited by 9 publications

(4 citation statements)

References 99 publications

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“…In this case, microscopic analysis of cells reflects a remarkable decrease in MI, reaching a maximum of 9 ± 0.7 and 9.8 ± 1.2 at 500 mg L −1 treatment in P. sativum and L. culinaris , respectively. According to several investigations using eukaryotic models as bioindicators, e.g., Hediste diversicolor (Nogueira and Nunes 2021 ), Hyalella azteca (Gómez-Oliván et al 2012 ), Daphnia magna (Daniel et al 2019 ), Crassostrea gigas (Bebianno et al 2017 ), Dreissena polymorpha (Parolini et al 2010 ), Gibbula umbilicalis (Giménez and Nunes 2019 ), Phorcus lineatus (Almeida and Nunes 2019 ), Ruditapes philippinarum (Correia et al 2016 ), Mytilus spp. (Piedade et al 2020 ), Rhamdia quelen (Perussolo et al 2019 ), Cyprinus carpio (Gutiérrez-noya et al 2020 ), Danio rerio (Xia et al 2017 ), Chlorella sp .…”

Section: Resultsmentioning

confidence: 99%

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Mercado

Galvis

2023

Environ Sci Pollut Res

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Paracetamol is one of the most widely used drugs worldwide, yet its environmental presence and hazardous impact on non-target organisms could rapidly increase. In this study, the possible cytotoxic effects of paracetamol were evaluated using two bioindicator plants Lens culinaris and Pisum sativum . Concentrations of 500, 400, 300, 200, 100, 50, 25, 5, 1 mg L −1 , and a control (distilled water) were used for a total of 10 treatments, which were subsequently applied on seeds of Lens culinaris Med . and Pisum sativum L. ; after 72 h of exposure, root growth, mitotic index, percentage of chromosomal abnormalities, and the presence of micronucleus were evaluated. The cytotoxic effect of paracetamol on L. culinaris and P. sativum was demonstrated, reporting the inhibition of root growth, the presence of abnormalities, and a significant micronucleus index at all concentrations used, which shows that this drug has a high degree of toxicity.

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Section: Resultsmentioning

confidence: 99%

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Mercado

Galvis

2023

Environ Sci Pollut Res

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“…However, these studies indicated that paracetamol exposure could highly affect metabolic response in aquatic organisms, suggesting toxic effects in continuous time. Moreover, paracetamol exposure also led to several effects on soil organisms, such as increased hypoactivity (28 days) and burrowing time (96 h) in Hediste diversicolor [ 48 ]. Paracetamol increases superoxide dismutase activity in intermediate exposure levels and glutathione peroxidase and glutathione reductase in chronic levels of exposure.…”

Section: Biotoxicity Of Pharmaceutical Active Compoundsmentioning

confidence: 99%

Modified polymer membranes for the removal of pharmaceutical active compounds in wastewater and its mechanism-A review

Ratnasari

2023

Bioengineered

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Membrane technology can play a suitable role in removing pharmaceutical active compounds since it requires low energy and simple operation. Even though membrane technology has progressed for wastewater applications nowadays, modifying membranes to achieve the strong desired membrane performance is still needed. Thus, this study overviews a comprehensive insight into the application of modified polymer membranes to remove pharmaceutical active compounds from wastewater. Biotoxicity of pharmaceutical active compounds is first prescribed to gain deep insight into how membranes can remove pharmaceutical active compounds from wastewater. Then, the behavior of the diffusion mechanism can be concisely determined using mass transfer factor model that represented by β and B with value up to 2.004 g h mg −1 and 1.833 mg g −1 for organic compounds including pharmaceutical active compounds. The model refers to the adsorption of solute to attach onto acceptor sites of the membrane surface, external mass transport of solute materials from the bulk liquid to the membrane surface, and internal mass transfer to diffuse a solute toward acceptor sites of the membrane surface with evidenced up to 0.999. Different pharmaceutical compounds have different solubility and relates to the membrane hydrophilicity properties and mechanisms. Ultimately, challenges and future recommendations have been presented to view the future need to enhance membrane performance regarding fouling mitigation and recovering compounds. Afterwards, the discussion of this study is projected to play a critical role in advance of better-quality membrane technologies for removing pharmaceutical active compounds from wastewater in an eco-friendly strategy and without damaging the ecosystem.

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“…For example, antineoplastic drugs used against cancer diseases are responsible to cause changes in the reproductive function, oxidative stress, genotoxicity, cytotoxicity and neurotoxicity [56]. Widely used analgesics (e.g., paracetamol) are systematically reported to occur in the wild, where they may exert effects on oxidative stress biomarkers [57][58][59].…”

Section: Environmental Impact and Risk Assessmentmentioning

confidence: 99%

Emerging Contaminants in Seafront Zones. Environmental Impact and Analytical Approaches

et al. 2021

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Some chemical substances have the potential to enter the coastal and marine environment and cause adverse effects on ecosystems, biodiversity and human health. For a large majority of them, their fate and effects are poorly understood as well as their use still unregulated. Finding effective and sustainable strategies for the identification of these emerging and/or anthropogenic contaminants that might cause polluting effects in marine environments to mitigate their adverse effects, is of utmost importance and a great challenge for managers, regulators and researchers. In this review we will evaluate the impact of emerging contaminants (ECs) on marine coastal zones namely in their ecosystems and biodiversity, highlighting the potential risks of organic pollutants, pharmaceuticals and personal care products. Emerging microextraction techniques and high-resolution analytical platforms used in isolation, identification and quantification of ECs will be also reviewed.

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Effects of paracetamol on the polychaete Hediste diversicolor: occurrence of oxidative stress, cyclooxygenase inhibition and behavioural alterations

Cited by 9 publications

References 99 publications

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L

Modified polymer membranes for the removal of pharmaceutical active compounds in wastewater and its mechanism-A review

Emerging Contaminants in Seafront Zones. Environmental Impact and Analytical Approaches

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