Effects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steers

Sartin, James L.; Kemppainen, Robert J.; Marple, D. N.; Carnes, R.; Dieberg, Gudrun; Oliver, E.H.

doi:10.1016/0739-7240(87)90036-1

Cited by 12 publications

(14 citation statements)

References 21 publications

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“…For example, in many species, the a-adrenergic sys- Values are expressed as means ± S E M , n = 6. * p < 0 .0 5 , ** p < 0.01. vs. control (0 pg/ml).a p = 0.06. tem stimulates G H secretion, while in sheep, a-adrenergic antagonists stimulate G H secretion [29], In some species, serotonin stimulates G H release [24,30], but serotonin inhibits G H release in sheep [31].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Endotoxin on Pituitary Hormone Secretion in Sheep

Coleman¹,

Elsasser²,

Kemppainen³

et al. 1993

Neuroendocrinology

106

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Endotoxin, a potent stimulator of the immune system and an important mediator in the pathophysiology of septic shock, has been shown to alter the release of certain hormones following its systemic administration. The purpose of this study was to determine the effects of endotoxin on pituitary hormone secretion both in vivo and in vitro in sheep, with emphasis placed on its effects on growth hormone (GH) release. Endotoxin (400 ng/kg i.v.) increased plasma GH, adrenocorticotropic hormone (ACTH), cortisol and prolactin, while it decreased luteinizing hormone (LH) pulse frequency (p < 0.05). Plasma levels of tumor necrosis factor, a major mediator of endotoxin effects, also increased following endotoxin administration. Endotoxin did not affect the GH response to human GH-releasing hormone. In vitro studies evaluated the effect of endotoxin to alter GH secretion from dispersed sheep anterior pituitary cells at dosages of 1, 10 and 50 µg/ml, with samples collected at 4, 8 and 24 h. Endotoxin increased pituitary GH secretion at 24 h for 1 µg/ml (p < 0.05) and at all time periods for 10 and 50 µg/ml (p < 0.05). It also led to an increased release of ACTH and LH in vitro. The results of this study demonstrate the ability of endotoxin to alter pituitary hormone secretion both in vivo and in vitro in sheep, suggesting a direct effect of endotoxin on the pituitary gland.

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Section: Discussionmentioning

confidence: 99%

“…Nashville. Tenn., U SA ) [24]. Medium A C T H was assayed using antisera AFP6328031 from N ID D K D .…”

Section: In Vitro Studiesmentioning

confidence: 99%

Effect of Endotoxin on Pituitary Hormone Secretion in Sheep

Coleman¹,

Elsasser²,

Kemppainen³

et al. 1993

Neuroendocrinology

106

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“…1987). In cattle, quipazine, a non‐selective serotonin agonist, stimulated GH release when it was administered peripherally (Sartin et al. 1987; Gaynor et al.…”

Section: Introductionmentioning

confidence: 99%

A possible role of central serotonin in L‐tryptophan‐induced GH secretion in cattle

Kasuya¹,

Yayou²,

Hashizume³

et al. 2010

Animal Science Journal

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To clarify the role of serotonin (5-HT) in the regulatory mechanism of L-tryptophan (TRP)--induced growth hormone (GH) secretion in cattle, changes in 5-HT concentrations in the cerebrospinal fluid (CSF) in the third ventricle (3V) and GH in plasma before and after the peripheral infusion of TRP were determined simultaneously. The direct effect of TRP on GH release from the dispersed anterior pituitary cells was also assessed. A chronic cannula was placed in 3V by stereotaxic surgery, then CSF and blood were withdrawn under physiological conditions. TRP (38.5 mg/kg BW) was infused through an intravenous catheter from 12.00 to 14.00 hours and CSF and blood sampling were performed from 11.00 to 18.00 hours at 1-h intervals. The concentration of 5-HT in CSF was determined by high-performance liquid chromatography with electrochemical detection. GH, melatonin (MEL), and cortisol (CORT) concentrations were measured by radio-immunoassay and enzyme-immunoassay. Concentrations of 5-HT were increased by TRP infusion. The TRP infusion significantly increased GH release. On the other hand, TRP did not stimulate GH release from the bovine pituitary cells. MEL and CORT concentrations were not altered by TRP infusion. These results suggest that TRP induced GH release via the activation of serotonergic neurons in cattle.

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“…2). It has been reported that GH secretion is clearly stimulated by peripheral injection of quipazine, the agonist of 5‐HT receptors in cattle (Sartin et al . 1987; Gaynor et al .…”

Section: Discussionmentioning

confidence: 99%

“…The systemic injection of quipazine, a 5‐HT agonist, induces increases in GH concentration dramatically in cattle (Vijayan et al . 1978; Sartin et al . 1987; Gaynor et al .…”

Section: Introductionmentioning

confidence: 99%

Effects of serotonin injected into the third ventricle on prolactin and growth hormone secretion in Holstein steers

Kasuya

Kushibiki

Yayou

et al. 2008

Animal Science Journal

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In order to clarify the role of serotonin (5‐HT) in the regulation of pituitary hormones, the effects of 5‐HT injected into the third ventricle (3V) on prolactin (PRL) and growth hormone (GH) release were investigated in Holstein steers. A chronic cannula was implanted in 3V by stereotaxic surgery under general anesthesia. After sufficient recovery from surgery, 5‐HT (0, 0.1, 1.0, 2.0 mg) was injected into via the cannula and blood samples were collected over 4 h. Plasma PRL and GH concentrations were determined by radioimmunoassay. PRL release was significantly stimulated by the injection of 5‐HT. The increase in PRL was observed at 20 min after the injection at three doses and the highest dose (2.0 mg) was the most effective in stimulating PRL release. The injection of 5‐HT into 3V, at all doses tested, did not alter GH release significantly. Our results suggest that 5‐HT is involved in the regulation of PRL release partly through the hypothalamus in cattle.

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Effects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steers

Cited by 12 publications

References 21 publications

Effect of Endotoxin on Pituitary Hormone Secretion in Sheep

Effect of Endotoxin on Pituitary Hormone Secretion in Sheep

A possible role of central serotonin in L‐tryptophan‐induced GH secretion in cattle

Effects of serotonin injected into the third ventricle on prolactin and growth hormone secretion in Holstein steers

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