Effects of Parasitic Infections in Pregnant Women

Reinhardt, M. C.

doi:10.1002/9780470720608.ch10

Cited by 10 publications

(2 citation statements)

References 46 publications

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“…1982). Congenital infection with both forms of African trypanosomiasis (gambiense and rhodesiense) have been described in a number of publications, but the frequency of infection is not known (Reinhardt 1980). The older literature has been reviewed by Debroise e f a/.…”

Section: Discussionmentioning

confidence: 99%

Congenital Trypanosomiasis in a Child Born in London

Lingam

Marshall

Wilson

et al. 1985

Develop Med Child Neuro

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SUMMARY A female infant of 22 months was referred to the Hospital for Sick Children, London, because of delayed psychomotor development. Extensive investigations revealed no cause, but eventually trypanosomiasis was diagnosed. The infant had not been outside the UK, but her mother came from Zaire, where the disease is endemic, but had lived in Kinshasa, where there is no sleeping sickness. It is thought that the mother may have been asymptomatically infected by a fresh‐blood transfusion four years earlier, since no other source of infection was apparent. RÉSUMÉ Trypanosomiase congénitale chez un enfant néà Londres Une fillette de 22 mois a été addressée a L'Hôpital des Enfants Malades de Londres en raison ďun retard du développement psychomoteur. Des examens multiples ne révélérent aucune cause mais une trypanosomiase fut diagnostiquée. L'enfant n'avait pas été en dehors du Royaume Uni mais sa mére venait de Zaire ou la maladie est endémique; cependant, cette mére vivait à Kinshasa, oú il n'y a pas de maladie du sommeil. Les auteurs pensent que la mére avait été infectée asymptomatiquement par une transfusion de sang frais quatre ans plus tôt car il n'y avait aucune autre source ďinfection apparente. ZUSAMMENFASSUNG Angeborene Trypanosomiasis bei einem in London geborenen Kind Ein 22 Monate altes Mädchen wurde wegen einer verzögerten psychomotorischen Entwicklung in das Hospital für kranke Kinder in London eingewiesen. Trotz umfangreicher Diagnostik konnte die Ursache nicht festgestellt werden, aber schließlich wurde eine Trypanosomiasis diagnostiziert. Das Kind war nie außerhalb des UK gewesen, aber seine Mutter kam aus Zaire, wo die Erkrankung endemisch ist, hatte aber in Kinshasa gelebt, wo es keine Schlafkrankheit gibt. Man nimmt an, daß die Mutter vier Jahre zuvor durch eine Frischblutkonserve asymptomatisch infiziert wurde, da sich keine andere Infektionsquelle fand. RESUMEN Tripanosomiasis congenita en un niño nacido en Londres Una niña de 22 meses de edad fue ingresada en el Hospital for Sick Children de Londres debido a un retraso en el desarrollo psicomotor. Las exploraciones extensivas no revelaron ninguna etiología pero eventualmente se diagnosticó una tripanosomiasis. La niña no habia estado fuera del Reino Unido, pero su madre venia del Zaire donde la enférmedad es endemica, pero habia vivido en Kinshasa donde no hay enfermedad del suefio. Se cree qu la madre había estado infectada asintomáticamente por una transfuseón de sangre fresca hacia cuatro años ya que no era aparente ninguna otra fuente de infección.

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Section: Discussionmentioning

confidence: 99%

Congenital Trypanosomiasis in a Child Born in London

Lingam

Marshall

Wilson

et al. 1985

Develop Med Child Neuro

Self Cite

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“…Viral, bacterial, and parasitic infections can also impact the pregnancy outcomes, by increasing the risk of abortion, congenital anomalies, stillbirth, intrauterine growth retardation, preterm birth, or neonatal death. [26][27][28][29][30][31] Besides the ectopic pregnancies described earlier, the effects of maternal infection with Schistosoma sp. on the pregnancy outcomes are not well known.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo

Campillo

Chabot

Awaca-Uvon

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Little is known about the effect of helminth infections on the natural gynecological and pregnancy course. Our goal was to assess the relationship between Wuchereria bancrofti and hookworm (HW) infections with pregnancy course and outcome in a group of 82 women living in a rural area of the Democratic Republic of the Congo. Demographics and information on gynecological and obstetrical histories were collected retrospectively with standardized questionnaires. Wuchereria bancrofti and HW infections were diagnosed using a filarial antigen-detection test and the Kato–Katz method, respectively. Analyses consisted of multivariable logistic regressions adjusting for age, number of deliveries, and history of anthelmintic treatment (HAHT). The median age of study participants was 35 (interquartile range [IQR]: 30–44) years, and the median number of deliveries was five (IQR: 3–7). Wuchereria bancrofti and HW infection rates were 44.5% and 43.3%, respectively. Filarial antigenemia and HW infection were not significantly associated with the number of deliveries. The proportions of women with a history of pregnancy resulting in neonatal death, miscarriage, premature birth, and postpartum hemorrhage were 56%, 44%, 23%, and 36%, respectively. History of pregnancy associated with neonatal death was less frequent in women with HAHT, tended to be more frequent in women with filarial antigenemia, and was not associated with HW infection. None of the three other pregnancy events studied (miscarriage, premature birth, and postpartum hemorrhage) were associated with filarial antigenemia or HW infection. The positive association found between HAHT and lower risk of neonatal death warrants investigation in larger groups of women.

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Infection in Pregnancy and the Neonatal Period

Holzel¹

1993

Fetal and Neonatal Pathology

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Effects of Parasitic Infections in Pregnant Women

Cited by 10 publications

References 46 publications

Congenital Trypanosomiasis in a Child Born in London

Congenital Trypanosomiasis in a Child Born in London

Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo

Infection in Pregnancy and the Neonatal Period

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