Effects of Parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological parameters in streptozotocin induced diabetic rats

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

“…Histopathological observation revealed destruction of the islets of Langerhans in the diabetic control group as indicated by their smaller sizes when juxtaposed with healthy rats, this is a possible explanation for the reduction in insulin secretion in the diabetic rats, since β‐cells are critical to insulin function. These observations are similar to previous reports (Chaudhary et al, 2016; Ekperikpe et al, 2019; Katisart & Rattana, 2017; Kotha et al, 2019). We also observed abnormalities in the architecture of the β‐cells tissue of the diabetic rats, which was reversed by treatment with T. triandra.…”

“…A marked reduction in total protein, albumin, and globulin levels of diabetic rats was observed, this is indicative of diabetes‐induced liver damage. Hyperglycemic conditions causes the breakdown of structural proteins as a result of heightened conversion of amino acids to glucose (Ekperikpe et al, 2019; Goboza et al, 2019), this in turn negatively affects the synthesis of proteins such as albumin and globulin. We observed that T. triandra caused an increase in protein levels of the treated rats.…”

“…Elevated level of bilirubin as observed in the untreated diabetic group is another indicator of hepatic compromise. This may be due to decreased hepatic uptake, decreased bilirubin conjugation and elevated formation of bilirubin (Ekperikpe et al, 2019). The total and direct bilirubin level in the serum were found to significantly decrease after treatment with T. triandra .…”

“…Although diabetes is incurable, it can be managed by a combination of lifestyle changes and medication. Huge successes have been recorded with respect to finding effective management therapies for diabetes giving rise to drugs like alpha‐glucosidase and alpha‐amylase inhibitors, sulfonylureas, biguanides, meglitinides, thiazolidinediones, dipeptidyl peptidase 4, and glucagon‐like peptide‐1 agonist that are currently employed in the treatment of diabetes (Ekperikpe, Owolabi, & Olapeju, 2019; Irons & Minze, 2014). However, there are still several challenges despite the progresses made so far.…”

Fate of proteic and lipidic compounds during production of a traditional legume condiment (Soumbala) made from African Locust Bean (Parkia biglobosa) seeds

“…Consumption of such products, with a very distinctive odour and taste, has decreased over the past decades for the benefit of industrial alternatives (Ham, 2017). However, current nutritional and sustainability considerations encourage agronomist, nutritionist and food scientists to pay attention again to this very interesting legume and its transformation (Bari et al ., 2016; Ham, 2017; Abbas et al ., 2018; Lado et al ., 2018); Ekperikpe et al ., 2019). ALBS are nutritionally interesting since they present a balanced composition of protein (39 à 47%), lipids (31 à 40%) and carbohydrates (12 à 16%) (Odunfa, 1985; Ndir et al ., 2000; Esenwah & Ikenebomeh, 2008).…”