Effects of partial locus coeruleus denervation and chronic mild stress on behaviour and monoamine neurochemistry in the rat

Häidkind, Riina; Eller, Marika; Harro, Maarike; Kask, Ants; Rinken, Ago; Oreland, Lars; Harro, Jaanus

doi:10.1016/s0924-977x(02)00076-7

Cited by 44 publications

(44 citation statements)

References 55 publications

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“…Since acute or subchronic treatment with URB597 enhances firing of serotonergic and noradrenergic neurons in the midbrain (Gobbi et al 2005), it is possible that persistent anandamide accumulation in this region might contribute to the antidepressant-like effects of URB597 in CMS (Haidkind et al 2003;Liu et al 2003;Papp et al 1994). Testing this hypothesis will require, however, further experimentation.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Bortolato

Mangieri

et al. 2007

Biological Psychiatry

317

255

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Section: Discussionmentioning

confidence: 99%

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Bortolato

Mangieri

et al. 2007

Biological Psychiatry

317

255

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“…In addition to these effects, which by analogy with the 'anhedonic profi le' described earlier could be described as 'prohedonic', table 4 also lists a series of studies, from the same group, in which CMS caused a decrease in immobility in the forced swim test [19,87,89] , in contrast to the increased immobility reported by all other groups ( table 3 ). Although the forced swim test does not measure sensitivity to reward, these results are included here because, as discussed above, several research groups have reported that the effects of CMS in the forced swim test are consistent with its effects on rewarded behaviour: in conditions where CMS causes anhedonic effects, it also increases immobility in the forced swim test (see table 3 : entries in italics).…”

Section: Anomalous Effects Of Cmsmentioning

confidence: 97%

“…These include two series of studies reporting a decreased intake of palatable food intake in brief (3 or 5 min) sessions in rats [89,95,96,98] , and a similar effect in mice [82,97] , and one study that actually reported an increase in total intake of palatable food, but in the context of a very slow rate of eating in a much longer (30 min) session [98] . In the studies by Di Chiara and colleagues [100,101] , the dependent measure was dopamine release in nucleus accumbens shell and prefrontal cortex in response to the taste of a palatable food: these measures were both decreased by CMS.…”

Section: Effects Of Cms On Other Measures Of Hedonic Reactivitymentioning

confidence: 99%

“…For example: in some studies the decrease in sucrose intake by rats was unstable over time [31] or habituated rapidly [19,53] ; Harris et al [75] reported a decrease in saccharin preference in only one study out of three; and the studies of Gronli et al [27,28] , in which CMS decreased sucrose intake in rats, is balanced by another study from the same group reporting the opposite effect, an increase in sucrose intake [86] : indeed, as discussed below, there are several other reports of similar anomalous fi ndings. There are also some reports that CMS did not signifi cantly alter sucrose intake [87 (abstract); 88,89] . (A number of similar, unpublished studies are known to the author from personal communications [5] , as, also, are some further unpublished studies showing positive effects of CMS.)…”

Section: Introductionmentioning

confidence: 99%

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Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

Willner¹

2005

Neuropsychobiology

1,445

1,023

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The chronic mild stress (CMS) model of depression has high validity but has in the past been criticized for being difficult to replicate. However, a large number of recent publications have confirmed that CMS causes behavioural changes in rodents that parallel symptoms of depression. This review summarizes studies from over sixty independent research groups that have reported decreases in reactivity to rewards, and a variety of other depression-like behaviours, in rats or mice, following exposure to CMS. Together, these changes are referred to as a ‘depressive’ behavioural profile. Almost every study that has examined the effects of chronic antidepressant treatment in these procedures has reported that antidepressants were effective in reversing or preventing these ‘depressive’ behavioural changes. (The single exception is a study in which the duration of treatment was too brief to constitute an adequate trial.) There are also a handful of reports of CMS causing significant effects in the opposite direction, termed here an ‘anomalous’ behavioural profile. There are six neurobiological parameters that have been studied in both ‘anhedonic’ and ‘anomalous’ animals: psychostimulant and place-conditioning effects of dopamine agonists; dopamine D₂ receptor number and message; inhibition of dopamine turnover by quinpirole, and beta-adrenergic receptor binding. On all six measures, CMS caused opposite effects in animals displaying ‘depressive’ and ‘anomalous’ profiles. Thus, there is overwhelming evidence that under appropriate experimental conditions, CMS can cause antidepressant-reversible depressive-like effects in rodents; however, the ‘anomalous’ profile that is occasionally reported appears to be a genuine phenomenon, and these two sets of behavioural effects appear to be associated with opposite patterns of neurobiological changes.

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“…Descending projections from the LC to the spinal cord block nociceptive inputs, while projections ascending to the forebrain regulate emotional responses (Haidkind et al, 2003). Although the involvement of the LC in both pain and depression has been well established, its role in comorbid pain and depression remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats

Bravo

Torres-Sánchez

Alba-Delgado

et al. 2014

European Neuropsychopharmacology

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Depression can influence pain and vice versa, yet the biological mechanisms underlying how one influences the pathophysiology of the other remains unclear. Dysregulation of locus coeruleusnoradrenergic transmission is implicated in both conditions, although it is not known whether this effect is exacerbated in cases of co-morbid depression and chronic pain. We studied locus coeruleus activity using immunofluorescence and electrophysiological approaches in rats subjected to unpredictable chronic mild stress (CMS, an experimental model of depression) and/or chronic constriction injury (CCI, a model of chronic neuropathic pain) for 2 weeks. CCI alone had no effect on any of the locus coeruleus parameters studied, while CMS led to a slight reduction in the electrophysiological activity of the locus coeruleus. Furthermore, CMS was associated with an increase in the number of tyrosine hydroxylase-positive cells in the locus coeruleus, although they were smaller in size. Interestingly, these effects of CMS were exacerbated when combined with CCI, even though no changes in the α2-adrenoreceptors or the noradrenaline transporter were observed in any group. Together, these findings suggest that CMS triggers several modifications in locus coeruleus-noradrenergic transmission that are exacerbated by co-morbid chronic pain. & 2014 Elsevier B.V. and ECNP. All rights reserved. E-mail address: esther.berrocoso@uca.es (E. Berrocoso). European Neuropsychopharmacology (]]]]) ], ]]]-]]]Please cite this article as: Bravo, L., et al., Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats. European Neuropsychopharmacology (2014), http://dx

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Effects of partial locus coeruleus denervation and chronic mild stress on behaviour and monoamine neurochemistry in the rat

Cited by 44 publications

References 55 publications

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats

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