Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice

Zha, Hua; Tang, Ruiqi; Li, Shengjie; Zhuge, Aoxiang; Xia, Jiafeng; Lv, Jiawen; Wang, Shuting; Wang, Kaiceng; Zhang, Hua; Li, Lanjuan

doi:10.1016/j.chemosphere.2023.140940

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…Among the studies with exposure to both MPLs and NPLs in the same experimental conditions, four studies supported a greater intestinal toxicity of MPLs compared to NPLs [27,47,51,52]. The other five studies showed that the intestinal toxicity of NPLs was of a similar intensity to that of MPLs, but that the features of toxic effects were dependent on the size of the MNPLs [28,40,43,49,55]. The complete study performed by Zhang et al, which included different PS MNPL sizes and concentrations and 2-week and 4-week exposure durations, argued in favor of a greater influence of exposure duration and MNPL size compared to MNPL concentration on the gut toxicity of MNPLs [49].…”

Section: Resultsmentioning

confidence: 94%

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Djouina,

Loison,

Body-Malapel

2024

Microplastics

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The tremendous plastic production and poor post-use management are current and future sources of environmental and human contamination due to their degradation products: microplastics and nanoplastics (MNPLs). Methodological developments have allowed MNPLs to be detected in an increasing variety of human foods, as well as in stool and colonic mucosa. It was suggested early that the direct contact between MNPLs and intestinal tissues could represent a potential risk for human health. In order to assess this, over the last 3 years, numerous studies have evaluated the impact of MNPL ingestion on intestinal homeostasis in rodents. This comprehensive review reports the preclinical studies published between January 2021 and January 2024, and analyzes their contributions as well as their shortcomings. It shows that evidence is accumulating of the intestinal toxicity of spherical MNPLs, which lead to pro-inflammatory, pro-oxidative, barrier-disruptive and dysbiotic effects. However, the available literature has addressed only a minor part of the potential health issues of MNPLs. Many parameters contributing to MNPL toxicity need to be better taken into account in future studies. Particular attention should be paid to improve the representativeness of MNPLs, as well as to better consider the susceptibility factors of MNPL toxicity, generated especially by an underlying pathology or pathological imprinting.

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Section: Resultsmentioning

confidence: 94%

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Djouina,

Loison,

Body-Malapel

2024

Microplastics

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“…[17] Recently, studies have drawn a connection between gut microbiome and liver toxicity caused by PS MNPs in healthy mice. [18][19][20] The oxidative stress induced by in ammation can favor the bloom of more resistant bacterial groups, such as the members of Enterobacteriaceae, altering the gut's microbial ecosystem. MNPs serve as vectors for microbial dispersal, potentially introducing pathogens into the gut.…”

Section: Introductionmentioning

confidence: 99%

Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome

Kopatz,

Draganic,

Horvath

et al. 2024

Preprint

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Background The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro- and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD and exposure to MNPs, we induced colitis in mice using dextran sodium sulfate (DSS) and orally administered a solution of differently sized polystyrene (PS) MNPs (diameter 10, 1, and 0.29 µm). These particles facilitated a detailed examination of MNP biodistribution, macrophage response, and gut microbiome alterations under inflammatory conditions. Results Specifically nanosized PS particles accumulated in the bloodstream and excretory organs, with enhanced accumulation in the colitis model. Macrophages shifted towards a pro-inflammatory phenotype, with decreased anti-inflammatory markers highlighting the intricate effects of MNPs on inflammation and immune cell behavior. Moreover, MNPs significantly disrupted the gut microbiome, reducing microbial diversity and shifting bacterial populations towards pro-inflammatory and potentially pathogenic species. Conclusions These changes suggest that MNP exposure could exacerbate colitis through complex interactions involving MNPs, immune responses, and microbial dynamics. The fast growing exposure to MNPs underscores the urgent need for comprehensive public health strategies to address MNP pollution, its implications for disease and potential impacts on public health.

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A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review

Zhang,

García-Pérez,

Muñoz-Palazon

et al. 2024

Science of The Total Environment

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Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice

Cited by 4 publications

References 62 publications

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome

A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review

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