Effects of particle dipole interaction on the ac magnetically induced heating characteristics of ferrite nanoparticles for hyperthermia

Jeun, Minhong; Bae, Seongtae; Tomitaka, Asahi; Takemura, Yasushi; Park, Ki Ho; Paek, Sun Ha; Chung, Kyu‐Rhim

doi:10.1063/1.3211120

Cited by 88 publications

(47 citation statements)

References 12 publications

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“…A decrease in the initial susceptibility with increasing c is observed, so that the stronger the interaction between particles, the lower the hyperthermia response. Our results partially agree with those published by Wang et al 27 but run contrary to the findings in polydisperse ferrofluids reported by Jeun et al, 28 although we think that the different system analyzed in the latter ͑sample concentration is described as related to the size distribution, whereas in our case a monodisperse system is assumed͒ may be responsible for such discrepancy. Figure 4͑b͒ shows magnetization curves as a function of the amplitude of the magnetic field for c = 0.007, where the importance of the field with respect to H a is underlined: for fields H Ͻ H c = 0.48 H a there is almost no noticeable effect in the area of the cycle, whereas for values H c Ͻ H Ͻ H a large increases are observed.…”

Section: -3contrasting

confidence: 57%

Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles

Serantes

Baldomir

Martínez-Boubeta

et al. 2010

Journal of Applied Physics

172

152

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Published by the American Institute of Physics. Related ArticlesFe3O4-citrate-curcumin: Promising conjugates for superoxide scavenging, tumor suppression and cancer hyperthermia J. Appl. Phys. 111, 064702 (2012) Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors AIP Advances 2, 011208 (2012) In vitro cytotoxicity of Selol-loaded magnetic nanocapsules against neoplastic cell lines under AC magnetic field activation J. Appl. Phys. 111, 07B335 (2012) Magnetically driven spinning nanowires as effective materials for eradicating living cells J. Appl. Phys. 111, 07B329 (2012) Experimental characterization of electrochemical synthesized Fe nanowires for biomedical applications J. Appl. Phys. 111, 056103 (2012) Additional information on J. Appl. Phys. We show both experimental evidences and Monte Carlo modeling of the effects of interparticle dipolar interactions on the hysteresis losses. Results indicate that an increase in the intensity of dipolar interactions produce a decrease in the magnetic susceptibility and hysteresis losses, thus diminishing the hyperthermia output. These findings may have important clinical implications for cancer treatment.

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Section: -3contrasting

confidence: 57%

Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles

Serantes

Baldomir

Martínez-Boubeta

et al. 2010

Journal of Applied Physics

172

152

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“…However in most cases no detailed comparison between those materials are made. The exceptions are the work from Maehara et al, 42 who investigated seven types of ferrites but (unfortunately) at the micrometer range, Jeun et al 43 that reported hyperthermia studies with particles around 30 nm of three ferrites, namely Co, Ni and Mgbased ones, and within the same size range of this investigation the interesting work of Lee et al 44 which reported data on Co, Fe and Mn-based ferrites as well as exchange-coupled crystalline coreshell (hard-soft magnetic) nanostructures. Nevertheless, it is known that larger particle sizes might be influenced by incoherent rotation (curling/vortex-like for soft magnets) or domain-wall motion, which need to be correctly modeled in order to make a fair comparison with experimental data.…”

Section: Different Ferrite-based Nanoparticlesmentioning

confidence: 99%

Field dependent transition to the non-linear regime in magnetic hyperthermia experiments: Comparison between maghemite, copper, zinc, nickel and cobalt ferrite nanoparticles of similar sizes

et al. 2012

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Further advances in magnetic hyperthermia might be limited by biological constraints, such as using sufficiently low frequencies and low field amplitudes to inhibit harmful eddy currents inside the patient's body. These incite the need to optimize the heating efficiency of the nanoparticles, referred to as the specific absorption rate (SAR). Among the several properties currently under research, one of particular importance is the transition from the linear to the non-linear regime that takes place as the field amplitude is increased, an aspect where the magnetic anisotropy is expected to play a fundamental role. In this paper we investigate the heating properties of cobalt ferrite and maghemite nanoparticles under the influence of a 500 kHz sinusoidal magnetic field with varying amplitude, up to 134 Oe. The particles were characterized by TEM, XRD, FMR and VSM, from which most relevant morphological, structural and magnetic properties were inferred. Both materials have similar size distributions and saturation magnetization, but strikingly different magnetic anisotropies. From magnetic hyperthermia experiments we found that, while at low fields maghemite is the best nanomaterial for hyperthermia applications, above a critical field, close to the transition from the linear to the non-linear regime, cobalt ferrite becomes more efficient. The results were also analyzed with respect to the energy conversion efficiency and compared with dynamic hysteresis simulations. Additional analysis with nickel, zinc and copper-ferrite nanoparticles of similar sizes confirmed the importance of the magnetic anisotropy and the damping factor. Further, the analysis of the characterization parameters suggested core-shell nanostructures, probably due to a surface passivation process during the nanoparticle synthesis. Finally, we discussed the effect of particle-particle interactions and its consequences, in particular regarding discrepancies between estimated parameters and expected theoretical predictions.

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“…Experiments range from the physical studies of the nanoparticles and the liquid 1,2 to medical studies on toxicity, 3 targeting ability, 4,5 intracellular mobility, 6 and the effectiveness of the heating. 7,8 Theoretically, most works deal with the general description of the particle assemblies, both analytically 9,10 and numerically.…”

Section: Introductionmentioning

confidence: 99%

Role of dipole-dipole interactions for hyperthermia heating of magnetic nanoparticle ensembles

2012

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For clinical hyperthermia treatment the heating efficiency of magnetic nanoparticle ensembles is a crucial element. Using efficient algorithms, this heating is studied numerically with a focus on the effects of dipole-dipole interparticle interactions. For the time evolution of realistically modeled systems an approach based on the Landau-Lifschitz-Gilbert equation of motion with Langevin dynamics is taken. Our results suggest a widely negative influence of dipole-dipole interactions on the heating power of nanoparticles. However, considering ensembles within a fixed, given sample volume an optimal particle density exists. The presented results may have important implications for the medical use of magnetic hyperthermia treatment.

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Effects of particle dipole interaction on the ac magnetically induced heating characteristics of ferrite nanoparticles for hyperthermia

Cited by 88 publications

References 12 publications

Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles

Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles

Field dependent transition to the non-linear regime in magnetic hyperthermia experiments: Comparison between maghemite, copper, zinc, nickel and cobalt ferrite nanoparticles of similar sizes

Role of dipole-dipole interactions for hyperthermia heating of magnetic nanoparticle ensembles

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