Effects of particulate matter on allergic respiratory diseases

Wu, Jinzhun; Ge, Dongyu; Zhou, Linfu; Hou, Lingyun; Zhou, Ying; Li, Qiyuan

doi:10.1016/j.cdtm.2018.04.001

Cited by 101 publications

(75 citation statements)

References 70 publications

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“…However, experimental studies suggest that DEP alone had no effect on the major phenotypes of allergic asthma . By contrast, DEP co‐exposure with HDM exacerbated allergic responses, including airway hyper‐responsiveness, increased levels of allergen‐specific IgE, and accumulations of eosinophils and Th2/Th17 cells . These findings were well supported by our findings in this study.…”

Section: Discussionsupporting

confidence: 89%

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Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Wang

Liu

et al. 2019

Allergy

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Background Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co‐exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1‐induced asthma and its underlying mechanisms. Methods The effect of BaP was investigated in Der f 1‐induced mouse model of asthma, including airway hyper‐responsiveness, allergic inflammation, and epithelial‐derived cytokines. The impact of BaP on Der f 1‐induced airway epithelial cell oxidative stress (ROS) and cytokine release was further analyzed. The role of aryl hydrocarbon receptor (AhR) signaling in BaP‐promoted Der f 1‐induced ROS, cytokine production, and allergic inflammation was also investigated. Results Compared with Der f 1, BaP co‐exposure with Der f 1 led to airway hyper‐responsiveness and increased lung inflammation in mouse model of asthma. Increased expression of TSLP, IL‐33, and IL‐25 was also found in the airways of these mice. Moreover, BaP co‐exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL‐33, but not IL‐25, expression. Interestingly, AhR antagonist CH223191 or cells with AhR knockdown abrogated the increased expression of ROS, TSLP, and IL‐33. Furthermore, ROS inhibitor N‐acetyl‐L‐cysteine (NAC) also suppressed BaP co‐exposure‐induced expression of epithelial TSLP, IL‐33, and IL‐25. Finally, AhR antagonist CH223191 and NAC inhibited BaP co‐exposure with Der f 1‐induced lung inflammation. Conclusions Our findings suggest that BaP facilitates Der f 1‐induced epithelial cytokine release through the AhR‐ROS axis.

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Section: Discussionsupporting

confidence: 89%

“…The prevalence of asthma has been increasing over the past few decades, and the increase may be attributed to industrialization‐ and urbanization‐generated environmental pollutants . Environmental pollutants, which coexist with allergens, may contribute to the exacerbation of asthma.…”

Section: Introductionmentioning

confidence: 99%

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Wang

Liu

et al. 2019

Allergy

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“…Particulates of different aerodynamic diameters may lead to different inflammatory responses in the respiratory tract, 35 and the mechanisms underlying the interaction between PM and the immune system still need to be elucidated and addressed clinically. 36 Furthermore, the biological effects of particulates are based on their chemical compositions, which may depend on the diameter of particulates. We found no clear association between traffic metrics and severity of rhinitis, a result consistent with previous ESCAPE articles reporting associations of specific pollutants with asthma and lung function, but not with traffic metrics.…”

Section: Discussionmentioning

confidence: 99%

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Burte

Leynaert

Marcon

et al. 2020

Journal of Allergy and Clinical Immunology

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Background: Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. Objective: We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis. Methods: Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO 2 , PM 10 , PM 2.5 , and PM coarse (calculated by subtracting PM 2.5 from PM 10) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used. Results: A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd

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“…Particles modulate airway macrophages host defences by increasing IL-6 levels and suppressing CD11b macrophages in human alveoli. Particles were also capable of provoking Th2-mediate immune responses by increasing IL-10 secretion in lipopolysaccharide induced antigen-specific T cells through the Nrf2 signalling pathway (Wu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Exposure to Indoor Pollutants on Allergy and Lung Inflammation among School Children in Selangor, Malaysia: An Evaluation Using Factor Analysis

Isa

Hashim

Jalaludin

et al. 2020

Aerosol Air Qual. Res.

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A cross-sectional study of 470, 14-year-old students from 8 secondary schools located in suburban and urban areas in Hulu Langat district, Selangor, Malaysia was undertaken to determine the impact of atmospheric indoor air pollutants on atopy, asthma, respiratory symptoms and lung inflammation among school children. The students were surveyed using ISAAC and ECRHS questionnaires, their FeNO levels were measured and allergic skin prick tests were conducted. Active and passive sampling was used to measure the classroom indoor air concentration of NO 2 , CO 2 , formaldehyde, PM 10 , PM 2.5 , temperature and relative humidity. Linear mixed model, two-levels multiple logistic regression, PCA and SPC were applied to determine the complex relationship between respiratory symptoms, personal factors, FeNO levels and atmospheric indoor pollutants. 20.6% of students reported daytime breathlessness and 55.5% reported having rhinitis in the last 12 months. Atopy was prevalent in 57.7% of students, with predominant sensitization to Derp1 (51.9%) and Derf1 (47.9%) among doctor's diagnosed asthmatic students. Indoor air pollutants in urban area schools were significantly higher than those in suburban areas (p < 0.001). There was a significant association between exposure to PM 10 (OR = 2.66, 95% CI: 1.33-5.30) with skin allergy symptoms in the past 12 months. The PCA suggested that the most prominent factor associated with increasing FeNO levels was PM 10 , with 73.5% of the variation. SPC predicted the pattern of FeNO at an upper confidence limit (UCL) of 104.21 ppb with increasing PM 10 concentration in the classroom (UCL = 40.23 µg m-3). Exposure to PM 10 and PM 2.5 significantly influenced the inflammation of the school children's lungs. Moreover, there were associations between self-reported wheezing, daytime and nocturnal attack of breathlessness with doctor's diagnosed asthma among school children.

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Effects of particulate matter on allergic respiratory diseases

Cited by 101 publications

References 70 publications

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

The Impact of Exposure to Indoor Pollutants on Allergy and Lung Inflammation among School Children in Selangor, Malaysia: An Evaluation Using Factor Analysis

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