Effects of passive smoke inhalation on the vocal cords of rats

Duarte, Josilene Luciene; Faria, Flávio Augusto Cardoso de; Ceolin, Danielle Santi; Cestari, Tânia Mary; Assis, Gérson Francisco de

doi:10.1016/s1808-8694(15)30057-4

Cited by 31 publications

(15 citation statements)

References 19 publications

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“…Authors hypothesized that a more chronic exposure may be required to compromise the functional integrity of the epithelium and increase leakiness. While the effects of chronic cigarette smoke exposures on TER have not been studied, damage to epithelial structure following chronic exposures was observed in rat and rabbit models (Duarte, Faria, Ceolin, Cestari, & Assis, 2006; Gaafar & Al-Mansour, 1981; Isik, Kalender, Yardimci, & Ergun, 2004). Vocal fold epithelium of rats exposed to 30 cigarettes per day for 25, 50, and 75 days demonstrated signs of hyperplasia (Duarte, et al, 2006).…”

Section: Vocal Fold Epithelial Barrier Injurymentioning

confidence: 99%

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Levendoski

Leydon

Thibeault

2014

J Speech Lang Hear Res

116

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Purpose Vocal fold epithelium is composed of layers of individual epithelial cells joined by junctional complexes constituting a unique interface with the external environment. This barrier provides structural stability to the vocal folds and protects underlying connective tissue from injury while being nearly continuously exposed to potentially hazardous insults including environmental or systemic-based irritants such as pollutants and reflux, surgical procedures, and vibratory trauma. Small disruptions in the epithelial barrier may have a large impact on susceptibility to injury and overall vocal health. The purpose of this article is to provide a broad-based review of our current knowledge of the vocal fold epithelial barrier. Methods A comprehensive review of the literature was conducted. Details of the structure of the vocal fold epithelial barrier are presented and evaluated in the context of function in injury and pathology. The importance of the epithelial-associated vocal fold mucus barrier is also introduced. Results/Conclusions Information presented in this review is valuable for clinicians and researchers as it highlights the importance of this understudied portion of the vocal folds to overall vocal health and disease. Prevention and treatment of injury to the epithelial barrier is a significant area awaiting further investigation.

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Section: Vocal Fold Epithelial Barrier Injurymentioning

confidence: 99%

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Levendoski

Leydon

Thibeault

2014

J Speech Lang Hear Res

116

View full text Add to dashboard Cite

show abstract

“…[10][11][12] Animal studies also revealed vocal fold changes, including hyperplasia, metaplasia, and keratinization, triggered by regular smoking. [13][14][15] The vocal fold is the most common site of laryngeal carcinoma, 16 and it is vulnerable to vapor produced by ENDS because the cord lies directly in the upper respiratory tract. We sought to evaluate the histopathologic effects of 4 weeks of exposure to vapor created by ENDS on the vocal fold mucosa of rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of Electronic Nicotine Delivery System on Larynx: Experimental Study

et al. 2015

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“…The causal relationship in which smoking has a direct effect on the change of the mucous membrane of the vocal cords has been verified by numerous animal experiments [29]. Rats exposed to second-hand smoking had significantly higher proportions of moderate and focal inflammation of the larynx than a control group [30].…”

Section: Discussionmentioning

confidence: 99%

Association between Second-Hand Smoking and Laryngopathy in the General Population of South Korea

2016

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PurposeThe relationship between second-hand smoking and laryngopathy has not yet been reported. Thus, this study investigates the relationship between second-hand smoking and laryngopathy and suggests basic empirical data to prevent laryngopathy.MethodsThis study analyzed 1,905 non-smokers over the age of 19 (269 men and 1,636 women) who completed the health questionnaire, laryngeal endoscope test, and urine cotinine test in the 2008 Korea National Health and Nutrition Examination Survey (KNHANES). Second-hand smoking was defined as a urine cotinine concentration of 50ng/ml and over. Confounding factors included age, gender, education, household income, occupation, alcohol consumption, and coffee consumption. Risk ratios (RR) and 95% confidence intervals (CI) were presented for the relationship between second-hand smoking and laryngopathy by using Poisson regression analysis.ResultsThere was a significant relationship between second-hand smoking and laryngopathy (p<0.05). After all compounding factors were adjusted, non-smokers exposed to second-hand smoking had a 2.5 times (RR = 2.47, 95% CI: 1.19–5.08) significantly higher risk of laryngopathy than non-smokers not exposed to second-hand smoking (p<0.05).ConclusionIn this epidemiological study, there was a significant relationship between second-hand smoking and laryngopathy. More effective anti-smoking policies are required to protect the health of both non-smokers and smokers.

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Effects of passive smoke inhalation on the vocal cords of rats

Abstract: It was concluded that the passive inhalation of cigarette smoke yields important morphological changes in the vocal fold epithelium, which may progress to neoplasia.

Cited by 31 publications

References 19 publications

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Effects of Electronic Nicotine Delivery System on Larynx: Experimental Study

Association between Second-Hand Smoking and Laryngopathy in the General Population of South Korea

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