Effects of Patient Preferences on Outcomes in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) Study

Abstract

Treatment guidelines that recommend either an evidence-based psychotherapy or antidepressant medication for nonpsychotic major depression can be extended to treatment-naive patients. Treatment preferences among patients without prior treatment exposure do not significantly moderate symptomatic outcomes.

Functional Connectivity of the Subcallosal Cingulate Cortex And Differential Outcomes to Treatment With Cognitive-Behavioral Therapy or Antidepressant Medication for Major Depressive Disorder

“…Brain-based measures of major depression are proving superior to clinical measures and patient preferences in signifying differential outcomes to depression treatments (7,8,10). Such measures may provide a basis for possible future algorithms for triaging subjects to the appropriate treatment, likely as a component within a multivariate approach to prediction.…”

“…The design of the Emory PReDICT study has been published previously (39), and the clinical results of the trial are published elsewhere (10). The overarching goal of PReDICT was to identify clinical and biological moderators of outcomes to CBT and antidepressant medication.…”

“…Depressive symptom severity has received the most attention among the clinical predictors but the largest patient-level meta-analyses found no difference in outcome among patients treated with CBT or antidepressant medication based on severity (7) or depressive clinical subtype (8). The consistent failure of clinical features meaningfully to inform treatment selection serves as an impetus to identify biomarkers predictive of treatment outcomes (9,10). Unfortunately, genetic testing, neuroimaging, and psychophysiological approaches, though promising, have not yet proven sufficiently accurate or replicable to warrant clinical application to individual patients (11).…”

Response rate profiles for major depressive disorder: Characterizing early response and longitudinal nonresponse

“…The current study evaluated data collected from the Emory Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study, for which the rationale, methods, and design have been previously published (Dunlop et al, 2012; Dunlop, Kelley et al, 2017). The study was conducted through the Emory Mood and Anxiety Disorders Program in English-language clinics at Emory University and in Spanish-language clinic at Grady Hospital in Atlanta.…”

Web-based Cognitive Behavioral Therapy Blended with Face-to-Face Sessions for Major Depression: a Randomized Clinical Trial (Preprint)

“…Dunlop et al reported that patients matched to their preferred treatment could achieve a higher rate of treatment completion than those who were mismatched [44].…”