1985
DOI: 10.1289/ehp.856035
|View full text |Cite
|
Sign up to set email alerts
|

Effects of PCBs and related compounds on hepatocarcinogenesis in rats and mice.

Abstract: Commercial mixtures of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) can cause hepatocellular carcinoma in rats and mice. Present evidence indicates that these chemicals act as promoters and not initiators of hepatocarcinogenesis. Our results show that Firemaster BP-6 (FM) and its nontoxic major congener, 2,2',4,4',5,5'-hexabromobiphenyl (HBB), act as promoters in the two-stage model for hepatocarcinogenesis devised by Pitot and associates. A toxic congener, 3,3',4,4',5,5'-HBB, also was… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
3
1
1

Year Published

1987
1987
2015
2015

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 19 publications
(5 citation statements)
references
References 38 publications
0
3
1
1
Order By: Relevance
“…Thus, the tumors seen in E 2 -treated mice reflect the species-specific E 2 -mediated tumor susceptibility of BALB/cCrgl mice. In contrast to findings in the literature that mixtures of PCBs promote hepatocellular carcinoma ( Dutch Expert Committee 1995 ; Mayes et al 1998 ; Sleight 1985 ), a variety of malignant tumors were identified in the OH-PCB–treated mice, but only one mouse developed a hepatocellular carcinoma; thus, the mechanisms are likely to be very different.…”
Section: Discussioncontrasting
confidence: 75%
“…Thus, the tumors seen in E 2 -treated mice reflect the species-specific E 2 -mediated tumor susceptibility of BALB/cCrgl mice. In contrast to findings in the literature that mixtures of PCBs promote hepatocellular carcinoma ( Dutch Expert Committee 1995 ; Mayes et al 1998 ; Sleight 1985 ), a variety of malignant tumors were identified in the OH-PCB–treated mice, but only one mouse developed a hepatocellular carcinoma; thus, the mechanisms are likely to be very different.…”
Section: Discussioncontrasting
confidence: 75%
“…In contrast to LC-PCBs, the tumor promoting activity of certain PCB mixtures has been partially attributed to their enzyme-inducing properties (Alvares et al, 1977, Knerr and Schrenk, 2006). The fact that the higher-chlorinated congeners are generally better inducers than LC-PCBs might explain the synergistic carcinogenicity of PCB mixtures as opposed to individual congeners that was observed in previous in vivo studies (Hansen, 1998, Sleight, 1985). Another mechanism by which hydroxylated, and potentially quinone metabolites of PCBs exert tumor promoting activity is through inhibition of gap junctional intercellular communication (Machala et al, 2004).…”
Section: Pcb Metabolite Associated Toxicitiesmentioning
confidence: 84%
“…The mechanism of carcinogenesis for the acutely toxic congeners may involve their ability to cause cytotoxicity and produce necrosis. Such chemicals have been referred to as cytotoxic liver carcinogens [37,38]. Other congeners that are not acutely toxic but cause mitogenic stimulation of cell replication and increased organ size have been referred to as mitogenic liver carcinogens [37,38].…”
Section: Discussionmentioning
confidence: 99%
“…Such chemicals have been referred to as cytotoxic liver carcinogens [37,38]. Other congeners that are not acutely toxic but cause mitogenic stimulation of cell replication and increased organ size have been referred to as mitogenic liver carcinogens [37,38]. The PCB and PBB congeners that have characteristics of both the above groups may exert their effects via both mechanisms.…”
Section: Discussionmentioning
confidence: 99%