Effects of penicillin and streptomycin onPoecilocerus pictus—A cytological study

Subramanyam, S. V.; Reddy, G. Prem Veer

doi:10.1007/bf03050752

Proceedings of the Indian Academy of Sciences - Section B

1975

DOI: 10.1007/bf03050752

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Effects of penicillin and streptomycin onPoecilocerus pictus—A cytological study

S. V. Subramanyam

G. Prem Veer Reddy

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1980

1984

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Cited by 3 publications

References 13 publications

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Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index

Jaju

Ahuja

1983

Hum Genet

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Cytogenetic effects of three combinations of anti-tubercular drugs were evaluated on human lymphocytes in vivo and were compared with controls of two types: (1) newly diagnosed tuberculosis patients before starting therapy and (2) individuals from the general population. The drugs used were: isoniazid (INH), thiacetazone (TAZ), para-aminosalicylic acid (PAS), and streptomycin (SM). These drugs were tested in the following combinations: (a) INH + TAZ + SM, (b) INH + PAS + SM, (c) INH + SM. The frequency of chromosome aberrations was significantly increased in patients treated with both the triple drug combinations, i.e., with INH + TAZ + SM and INH + PAS + SM, whereas patients treated with INH + SM did not exhibit an increase in the frequency of chromosome aberrations as compared to the controls. Although both the triple drug combinations were clastogenic, none of the three drug combinations tested induced an increase in the frequency of sister chromatid exchanges (SCEs). In other words, the mechanisms leading to SCEs and chromosome aberrations may be different. SM appeared to depress the mitotic index in patients treated with INH + SM and INH + PAS + SM, though it was found to possess a mild anti-clastogenic effect. INH + TAZ + SM, on the other hand, enhanced the mitotic index. This enhanced mitotic index was probably due to the presence of TAZ.

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Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index

Jaju

Ahuja

1983

Hum Genet

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Studies on the effects of neomycin on puffing in chironomus

Rathore

Swakup

1980

Acta Histochemica

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Evaluation of Genotoxicity of Ampicillin and Carbenicillin on Human Lymphocytes in vitro: Chromosome Aberrations, Mitotic Index, Cell Cycle Kinetics, Satellite Associations of Acrocentric Chromosomes and Sister Chromatid Exchanges

Jaju

Ahuja

1984

Human Toxicology

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A large number of drugs have been introduced into man's environment in recent years, many of which have been shown to have mutagenic, teratogenic and carcinogenic effects. Keeping in view the potential hazardous effects of drugs and chemicals, it is desirable to test new drugs for their genotoxic effects prior to widespread use. 1 In the present investigation genetic effects of ampicillin and carbenicillin were studied in vitro in human lymphocytes using a number of end-points. 2 These drugs were added at a range of concentrations and times during a 72h culture period. Concentrations corresponding to the plasma level after receiving therapeutic doses as well as concentrations higher than the plasma levels were examined. 3 Neither drug affected the frequency of chromosome aberrations, satellite associations, mitotic index and cell turnover rate at plasma level concentrations. However, all these parameters were affected at higher concentrations. 4 The frequency of SCEs was not increased with both the drugs irrespective of the concentrations or durations of treatment, suggesting that the mechanisms leading to the formation of SCEs and chromosome aberrations are different. 5 Both ampicillin and carbenicillin were genetically non-toxic for the end points measured and non-clastogenic in vitro at therapeutic doses. However, previous studies have shown ampicillin to be clastogenic in vivo. 6 For evaluation of genetic toxicity, drugs should be tested both in vitro and in vivo.

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Effects of penicillin and streptomycin onPoecilocerus pictus—A cytological study

Cited by 3 publications

References 13 publications

Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index

Cytogenetic effects of chemotherapy with three combinations of anti-tubercular drugs involving isoniazid, thiacetazone, para-aminosalicylic acid and streptomycin on human lymphocytes: chromosome aberrations, sister chromatid exchanges and mitotic index

Studies on the effects of neomycin on puffing in chironomus

Evaluation of Genotoxicity of Ampicillin and Carbenicillin on Human Lymphocytes in vitro: Chromosome Aberrations, Mitotic Index, Cell Cycle Kinetics, Satellite Associations of Acrocentric Chromosomes and Sister Chromatid Exchanges

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