Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction

Developmental toxicity of perfluorononanoic acid in mice

“…However, profound neonatal mortality was noted in the 5 mg/kg group, with only 20% of the pups surviving to weaning. Although neonatal death was also reported after gestational exposure to PFOS and PFOA [50,65,[73][74][75][76], the profile of this adverse effect elicited by PFNA is different from those seen with the eight-carbon PFAAs. A majority of the newborns (rats or mice) exposed prenatally to high doses (15-20 mg/kg) of PFOS died within the first day of life [65]; some of those exposed to high doses (10-20 mg/kg) of PFOA survived about a day longer [50].…”

Per- and polyfluorinated substances (PFASs): Environmental challenges

“…While neonatal mortality caused in mice is PPARα-dependent with PFOA (it is not seen in PPAR-null mice), it is PPARα-independent with PFOS (it occurs in PPAR-null mice) [347]. The mechanisms of neonatal death caused by PFOA and PFOS in mice also appear to be different [233]. PFOA induces pancreatic and testicular tumors in rats, but not PFOS [215,216].…”

“…The observed effects occur in animals at doses generally much lower than those causing hepatic effects. Exposure of rodents to PFOS or PFOA during pregnancy resulted in litter resorption, delayed parturition, neonatal mortality, delayed eye opening, retarded postnatal growth and liver hypertrophy [110,229,[233][234][235]. These effects depend again on PFAS, species, strain, gender and dose, but also on timing of fetal and lactational exposures.…”

Involvement of NRF2 in Perfluorooctanoic Acid-Induced Testicular Damage in Male Mice1

“…After 1 week of acclimatization, mice were orally administrated with different concentrations of PFOA (2.5, 5 or 10 mg/kg/day) once daily for 14 consecutive days. The doses of PFOA (2.5-10 mg/kg/day) were chosen based on the previous observations [18][19][20]. Controls received an equivalent volume of water.…”