Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis

He, Huan; Chen, Wenjing; Yu, Wei; Zhang, Taifa; Geng, Wenfeng; Zhai, Jinxia

doi:10.1007/s11356-021-18338-w

Cited by 8 publications

(3 citation statements)

References 45 publications

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Section: Methodsmentioning

confidence: 99%

“…Animal experiments exhibit unique characteristics, necessitating a focus on their reproducibility and internal authenticity, so currently, there are no consistent standards for evaluating the quality of animal research. 17 The STAIR checklist was used in this article to assess the quality of the included studies. The STAIR committee, under the direction of M. Fisher, first published the STAIR list (the initial Stroke Therapy Academic Industry Roundtable) in 1999.…”

Section: Data Extraction and Literature Quality Evaluationmentioning

confidence: 99%

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Anti‐aging effect of peptides on Caenorhabditis elegans: a meta‐analysis

Huang,

Zhu,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDPeptides have been studied in Caenorhabditis elegans for anti‐aging research recently. Due to the lack of sufficient evidence, we conducted this meta‐analysis focusing on the anti‐aging effect of peptides in C. elegans to provide more convincing evidence.RESULTSA literature search in PubMed, SCOUPUS, and Web of Science databases yielded 2879 articles. After removing duplicates and based on inclusion criteria and STAIR checklist quality assessment, 9 articles were selected. Data extraction and analysis showed that, compared to the control group without peptide intervention, peptide supplementation significantly reduced nematode mortality risk (HR= 0.54, 95% CI = 0.47, 0.62; p < 0.05), significantly increased the pharyngeal pumping rate (SMD = 1.64, 95% CI = 0.87, 2.41; p < 0.05), bending frequency (SMD = 1.67, 95% CI =1.16, 2.18; p < 0.05), and significantly decreased the accumulation of lipofuscin levels within nematodes (SMD = ‐4.48, 95% CI = ‐6.85, ‐2.12; p < 0.05). Additionally, subgroup analysis showed that doses ranging from 0.1–1 kg m3 ^‐1 (HR= 0.50, 95% CI = 0.38, 0.65; p < 0.05) displayed better anti‐aging effects compared to other dose ranges.CONCLUSIONThe findings suggest that peptides can significantly extend the lifespan of C. elegans under normal circumstances and improve three indicators of healthylife. More importantly, subgroup analysis revealed that a dosage of 0.1–1 kg m3 ^‐1 demonstrated superior anti‐aging effects. This meta‐analysis provides more convincing evidence that peptides can play an anti‐aging role in C. elegans.This article is protected by copyright. All rights reserved.

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Section: Methodsmentioning

confidence: 99%

Section: Data Extraction and Literature Quality Evaluationmentioning

confidence: 99%

Anti‐aging effect of peptides on Caenorhabditis elegans: a meta‐analysis

Huang,

Zhu,

Zhang

et al. 2024

J Sci Food Agric

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“…ATZ is banned in Europe, but it is the second most commonly used herbicide besides glyphosate [ 5 ]. Recent studies have shown in various species, including fish, amphibians, reptiles, and mammals, the reduction and induction in androgen and estrogen levels, respectively, which represent a possible mechanism able to explain the effect of ATZ on male development [ 6 , 7 ]. Cypermethrin (CYP, [cyano-(3-phenoxyphenyl)methyl] 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate, Figure 1 B), a pyrethroid pesticide, is largely used in agricultural production and daily life.…”

Section: Introductionmentioning

confidence: 99%

Effects of Subtoxic Concentrations of Atrazine, Cypermethrin, and Vinclozolin on microRNA-Mediated PI3K/Akt/mTOR Signaling in SH-SY5Y Cells

Graziosi

Sita

Corrieri

et al. 2022

IJMS

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Endocrine-disrupting chemicals (EDCs) are different natural and synthetic chemicals that may interfere with several mechanisms of the endocrine system producing adverse developmental, metabolic, reproductive, and neurological effects in both human beings and wildlife. Among pesticides, numerous chemicals have been identified as EDCs. MicroRNAs (miRNAs) can regulate gene expression, making fine adjustments in mRNA abundance and regulating proteostasis. We hypothesized that exposure to low doses of atrazine, cypermethrin, and vinclozolin may lead to effects on miRNA expression in SH-SY5Y cells. In particular, the exposure of SH-SY5Y cells to subtoxic concentrations of vinclozolin is able to downregulate miR-29b-3p expression leading to the increase in the related gene expression of ADAM12 and CDK6, which may promote a pro-oncogenic response through the activation of the PI3K/Akt/mTOR pathway and counteracting p53 activity. A better understanding of the molecular mechanisms of EDCs could provide important insight into their role in human disease.

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