Effects of periodontal therapy on glucose management in people with diabetes mellitus

Calabrese, Nicolino; D’Aiuto, Francesco; Calabrese, Alessia Maria; Patel, Kalpesh; Calabrese, Giuseppe; Massi‐Benedetti, Massimo

doi:10.1016/j.diabet.2011.05.004

Cited by 24 publications

(14 citation statements)

References 16 publications

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“…In the present study, some studies that did not fulfill the inclusion criteria reported positive effects of periodontal treatment on glycemic control [41][42][43] .…”

Section: Discussionmentioning

confidence: 72%

Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis

Corbella

Francetti

Taschieri

et al. 2013

J of Diabetes Invest

100

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Aims/Introduction: The aim of the present study was to investigate whether non-surgical periodontal treatment reduces glycated hemoglobin (HbA 1c ) and fasting plasma glucose (FPG) levels in diabetic patients. Materials and Methods: An electronic search was carried out on MEDLINE (through PubMed interface), EMBASE and the Cochrane Central Register of Controlled Trials. Randomized controlled trials with a minimum of 3 months follow up were included. The risk of bias was assessed for each study. A meta-analysis was carried out to evaluate the effect of non-surgical periodontal treatment on HbA 1c and FPG levels. The effect of the adjunctive use of antimicrobials was also assessed. Results: A total of 15 studies were included. A reduction of -0.38% (95% confidence interval [CI] -0.23 to -0.53) after 3-4 months (P < 0.001) and of -0.31% (95% CI 0.11 to -0.74) after 6 months (P = 0.15) of follow-up was found for HbA 1c , favoring the treatment group. Similarly, in treated patients, a significantly greater decrease in FPG was observed in respect to control participants. Such difference amounted to -9.01 mg/dL (95% CI -2.24 to -15.78) after 3-4 months (P = 0.009) and -13.62 mg/dL (95% CI 0.45 to -27.69) after 6 months (P = 0.06) from treatment, respectively. In participants treated with adjunctive antimicrobials, a non-significant increase of HbA 1c was observed 3 months after treatment, whereas FPG decreased by 0.27 mg/dL (95% CI 39.56 to -40.11; P = 0.99). Conclusions:The meta-analysis showed that non-surgical periodontal treatment improves metabolic control in patients with both periodontitis and diabetes. (J Diabetes Invest,

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“…In the present study, some studies that did not fulfill the inclusion criteria reported positive effects of periodontal treatment on glycemic control [41][42][43] .…”

Section: Discussionmentioning

confidence: 72%

Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis

Corbella

Francetti

Taschieri

et al. 2013

J of Diabetes Invest

100

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“…Therefore, 72 articles were assessed for elegibility 1,7,[11][12][13][14][15][16] (inter-reviewer agreement, k = 0.79). Of these, 61 articles 11,[13][14][15][16]26,[28][29][30][31][32][33][34][35][36][37][38][39]41,43,44,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][62][63][64][65][66][67][68][69]…”

Section: Search Resultsmentioning

confidence: 99%

Effectiveness of Periodontal Treatment to Improve Metabolic Control in Patients With Chronic Periodontitis and Type 2 Diabetes: A Meta‐Analysis of Randomized Clinical Trials

Sgolastra

Severino

Pietropaoli

et al. 2013

Journal of Periodontology

134

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“…Therefore, in diabetic patients with periodontitis, once the periodontal pathogen has been removed and inflammation subsides, HPDLFs can differentiate into the osteoblast lineage, which assists in bone regeneration. Intensive periodontal therapy can significantly reduce periodontal indices and HbA1c in diabetic patients with moderate periodontitis (24).…”

Section: Discussionmentioning

confidence: 99%

High glucose promotes the osteogenic differentiation capability of human periodontal ligament fibroblasts

Seubbuk

Sritanaudomchai

Kasetsuwan

et al. 2017

Molecular Medicine Reports

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Periodontal ligament fibroblasts (PDLFs) are important cells, which are involved in maintaining tooth integrity. Diabetes has been found to be associated with periodontal disease in a bidirectional manner. The aim of the present study was to investigate the stemness properties of human PDLFs (HPDLFs) in high glucose conditions. HPDLFs were analyzed for their osteogenic differentiation capacity by inducing the cells with osteogenic medium in various glucose concentrations. The gene expression was then examined using reverse transcription‑quantitative polymerase chain reaction analysis, and examinations of alkaline phosphatase activity and nodule formation were performed. The results of the gene expression analysis revealed that high glucose media induced the expression of NANOG, octamer-binding transcription factor 4, (sex determining region Y)‑box 2, cluster of differentiation 166 (CD166), PERIOSTIN and β‑CATENIN following culture of the cells for 3 days. Alkaline phosphatase activity increased following 14 days in the high glucose condition. In addition, higher numbers of calcified nodules were formed on day 28 in the group cultured with high glucose. The results showed that high glucose induced bone formation by elevating the expression of stem cell markers, particularly CD166, and this induction may be regulated through β-CATENIN.

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Effects of periodontal therapy on glucose management in people with diabetes mellitus

Cited by 24 publications

References 16 publications

Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis

Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis

Effectiveness of Periodontal Treatment to Improve Metabolic Control in Patients With Chronic Periodontitis and Type 2 Diabetes: A Meta‐Analysis of Randomized Clinical Trials

High glucose promotes the osteogenic differentiation capability of human periodontal ligament fibroblasts

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