Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer

Cai, Jun; Xuan, Zheng-Rong; Wei, Yong-ping; Yang, Haibo; Wang, Hua

doi:10.3736/jcim20050309

Cited by 8 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MXD is a modified version of XD, with the addition of three components: Astragalus, Frankincense, and Myrrh on the basis of XD. Rhubarb[ 50 - 53 ], Astragalus[ 54 - 58 ], and Magnolia officinalis[ 59 - 61 ] have immune protection effects and reduce the inflammatory stress response. MXD may improve the recovery of GI function of patients with cholelithiasis in the perioperative period under ERAS.…”

Section: Discussionmentioning

confidence: 99%

Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

Sun¹,

Zhang²,

Chen³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND In the perioperative period of biliary surgery, various factors can induce the release of a large number of inflammatory factors, leading to an imbalance in pro-inflammatory and anti-inflammatory responses and resulting in gastrointestinal (GI) dysfunction. Enhanced Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative recovery. It is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery, both of which are the basis and key for perioperative care and postoperative recovery. AIM To better understand the effects of Modified Xiao-Cheng-Qi decoction (MXD) on inflammatory response and GI function in the perioperative management of cholelithiasis and their correlation. METHODS This was a prospective randomized placebo-controlled trial, in which 162 patients who received biliary tract surgery were randomly assigned to three groups: MXD group, XD group, and placebo-control group. The observed parameters included frequency of bowel sounds, time of first flatus and defecation, time of diet, and amount of activity after surgery. The serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, serum amyloid A protein (SAA), and substance P were measured by the enzyme-linked immunosorbent assay. Then, the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and inflammation. RESULTS Compared to the placebo-control, improvements in GI function were observed in the MXD groups including reduced incidence of nausea, vomiting, and bloating; and earlier first exhaust time, first defecation time, and feeding time after surgery ( P < 0.05). On the 1 st and 2 nd d after surgery, IL-6, CRP and SAA levels in MXD group were lower than that in placebo control, but substance P level was higher, compared to the control ( P < 0.05). Functional diarrhea occurred in both MXD and XD groups without any other adverse effects, toxic reactions, and allergic reactions. Diarrhea was relieved after the discontinuation of the investigational remedies. Bowel sounds at 12 h after surgery, the occurring time of the first flatus, first defecation, postoperative liquid diet and semi-liquid diet were significantly correlated with levels of IL-6, CRP, SAA and substance P on second day after surgery ( P < 0.05). CONCLUSION Treatment with MXD can relieve inflammatory response and improve GI function after surgery. Moreover, there are significant correlations between them. Furthermore, it does not cause serious adverse reactions.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

Sun¹,

Zhang²,

Chen³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

show abstract

“…Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been reported to suppress the growth of tumor in some clinical situations (Cai et al, 2005;Mantani et al, 2002) and effectively inhibit tumor metastasis in vitro and in vivo Huang et al, 2006). Some studies investigated the effects and mechanisms of emodin on cell death in human prostate, lung, liver, and cervical, and blood cancer cells (Cha et al, 2005;Chen et al, 2002;Fu et al, 2007;Jing et al, 2002;Jing et al, 2006;Lee, 2001;Muto et al, 2007;Su et al, 2005;Yi et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

“…It has the effects of purgation, purging heat, loosening the bowels, curing metal and renal disorders and removing bacterial dysentery (Kang et al, 2006;Wang et al, 2007;Yue, 1990). Recent studies found that rhubarb has the action of antitumor and antimutagenicity (Cai et al, 2005, Kang et al, 2006Sun et al, 2000). Anthraquinones and bianthrones, including emodin and rhein were considered in the last decades as a cancer chemopreventative agent and therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Emodin-induced apoptosis in human breast cancer BCap-37 cells through the mitochondrial signaling pathway

2008

View full text Add to dashboard Cite

Emodin, a natural anthraquinone compound isolated from the rhizome of rhubarb, is reported to suppress the growth of tumor in many clinical situations. In this study, we focused on the effect of emodin in human breast cancer BCap-37 cells and further understand the underlying molecular mechanism in treating breast cancer. Using MTT assay and flow cytometry, we demonstrated the critical role of emodin in the suppression of the proliferation of BCap-37 cells based on a concentration-and time-dependent manner. The increase of apoptotic rate was also observed after incubation of BCap-37 cells on emodin at 20 microM and 50 microM for 48 h. The cells exhibited typical apoptotic features including cellular morphological change, chromatin condensation and membrane blebbing. The results of the study further showed that Bcl-2 level decreased, while Bax and cytosolic cytochrome c levels in sample cells increased after the emodin treatment by using Western blot. The decline in the Bcl-2/Bax ratio and the increase of cytosolic cytochrome c concentration were consistent with the increase of the apoptotic ratio. The results strongly suggest that the disruption of the mitochondrial signaling pathway was involved in emodin-induced apoptosis in BCap-37 cells.

show abstract

“…It is known to exert several biological effects, which involve purgative, antipyretic, anti-inflammatory, anti-angiogenic, and antineoplastic activities [ 13 – 15 ]. The previous study reported that the administration of rhubarb modulated acute inflammatory response in patients with gastric cancer [ 16 ]. Furthermore, we previously reported the increase in free radical scavenging activities of Rhei Rhizoma and Glycyrrhiza Rhizoma combined extract (RGE) in the inflammation induced ROS [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Rhei Rhizoma on reflux esophagitis in rats via Nrf2-mediated inhibition of NF-κB signaling pathway

Kwon

Choo

Lee

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundRhei Rhizoma has been widely used as a traditional herbal medicine to treat various inflammatory diseases. The present study was conducted to evaluate its anti-inflammatory activity against experimental reflux-induced esophagitis (RE) in SD rats.MethodsRhei Rhizoma was administered at 125 or 250 mg/kg body weight per day for 7 days prior to the induction of reflux esophagitis, and its effect was compared with RE control and normal rats.ResultsRhei Rhizoma administration markedly ameliorated mucosal damage on histological evaluation. The elevated reactive oxygen species in the esophageal tissue of RE control rats decreased with the administration of Rhei Rhizoma. RE control rats exhibited the down-regulation of antioxidant-related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression levels, in the presence of esophagitis; however, the levels with Rhei Rhizoma treatment were significantly higher than those in RE control rats. Moreover, RE control rats exhibited the up-regulation of protein expressions related to oxidative stress in the presence of esophagitis, but Rhei Rhizoma administration significantly reduced the expression of inflammatory proteins through mitogen-activated protein kinase (MAPK)-related signaling pathways. The protein expressions of inflammatory mediators and cytokines by nuclear factor-kappa B (NF-κB) activation were modulated through blocking the phosphorylation of inhibitor of nuclear factor kappa B (IκB)α.ConclusionOur findings support the therapeutic evidence for Rhei Rhizoma ameliorating the development of esophagitis via regulating inflammation through the activation of the antioxidant pathway.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0974-z) contains supplementary material, which is available to authorized users.

show abstract

Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer

Abstract: Rhubarb can positively modulate the acute inflammatory response, promote the recovery of postoperative gastrointestinal motility, and benefit enteral nutrition support in patients who have undergone major operations for gastric cancer.

Cited by 8 publications

References 3 publications

Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

Emodin-induced apoptosis in human breast cancer BCap-37 cells through the mitochondrial signaling pathway

Protective effect of Rhei Rhizoma on reflux esophagitis in rats via Nrf2-mediated inhibition of NF-κB signaling pathway

Contact Info

Product

Resources

About