Effects of peripheral administration of synthetic human glucose‐dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes

Daousi, Christina; Wilding, John; Aditya, Suruchi; Durham, B; Cleator, Jacqueline; Pinkney, Jonathan; Ranganath, L.

doi:10.1111/j.1365-2265.2008.03451.x

Cited by 53 publications

(54 citation statements)

References 32 publications

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“…The administration of GLP1 receptor agonists in T2DM improves glucose homeostasis, while it is followed by a dose-dependent weight loss compared with placebo (10)(11)(12). Furthermore, GIP, another incretin, has been associated with a decrease in resting energy expenditure in healthy humans (13). Ghrelin, discovered as a natural ligand of the GH secretagogue receptor type 1a, is a gut-brain peptide with somatotropic, food intake-increasing and adipogenic effects.…”

Section: Introductionmentioning

confidence: 99%

The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change

Valsamakis

Margeli

Vitoratos

et al. 2010

European Journal of Endocrinology

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Objective: Maternal weight in pregnancy contributes to a glycemic environment that affects fetal growth. Gut peptides (glucagon-like peptide 1 (GLP1), glucose-dependent insulinotropic peptide (GIP), ghrelin, and peptide YY (PYY)) have been related to insulin sensitivity and secretion, weight control, and adipose tissue metabolism. This study aimed at examining the associations of gut hormones during pregnancy with maternal glucose homeostasis, maternal weight, and fetal growth. Methods: A total of 55 pregnant nonobese, nondiabetic Caucasian women were examined during the three trimesters of pregnancy, and anthropometric measurements, evaluation of fasting maternal plasma GLP1 (active), ghrelin (active), total PYY, total GIP, and a 75-g oral glucose tolerance test were done in them. Homeostasis model assessment (HOMA-R), insulin sensitivity index (ISI), and indices of insulin secretion were calculated. Fetal growth was estimated by ultrasound. Results: Fasting GLP1 increased significantly from the second to the third trimester (P!0.05). Fasting GLP1 correlated positively with high-density lipoprotein cholesterol (rZ0.52, PZ0.04). At the second trimester, fasting GLP1 levels correlated negatively with fetal abdomen circumference (rZK0.55, PZ0.034), birth weight (rZK0.50, PZ0.040), HOMA-R (rZK0.65, PZ0.001), insulin secretion, and triglycerides. At the first trimester, fasting ghrelin levels correlated negatively with HOMA-R and insulin secretion, and positively with ISI. In backward multiple regression analysis, the first trimester GLP1 levels were the best negative predictors of the second trimester fetal abdomen circumference (bZK0.96, PZ0.009). In longitudinal regression model, maternal fat and HOMA-R were the positive predictors of maternal weight change during pregnancy, and fasting GLP1 levels were the negative predictors of maternal weight change during pregnancy. Conclusions: During pregnancy, maternal GLP1 might be involved in mechanisms that compensate for the pregnancy-related increase in glycemia and insulin resistance, suggesting a role of this peptide in maternal metabolism and weight and fetal growth.

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Section: Introductionmentioning

confidence: 99%

The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change

Valsamakis

Margeli

Vitoratos

et al. 2010

European Journal of Endocrinology

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“…Other studies have founded that postprandial GIP response was inversely related to the subsequent feeling of satiety (5,12,13). On the other hand, positive (14) or neutral (9,10,15) correlation between postprandial GIP and satiety were also observed.…”

Section: Introductionmentioning

confidence: 70%

Effects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity

et al. 2017

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Penaforte FRO, Japur CC, Diez-Garcia RW, Chiarello PG. Effects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity. AbstractBackground: Considering the possible role of triglycerides (TG), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the regulation of appetite, this study aimed to compare high fat meal-induced response of GIP and GLP-1, appetite scores and ad libitum energy intake in women with obesity, according to postprandial increment in triglyceridemia (∆TG). Methods: Thirty-three no-diabetic women (BMI = 35.0 ± 3.2 kg.m

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“…Daousi et al [26] reported that intravenous infusion of GIP reduces REE in healthy humans, suggesting that GIP has acute effects on energy catabolism. In the present study, blood GIP levels were reduced after consumption of steamed WB and, simultaneously with the decrease in the blood GIP levels, fat utilization was increased in mice fed the WB diet.…”

Section: Discussionmentioning

confidence: 99%

“…A genetic deficit in GIP-secreting K cells enhances energy expenditure and prevents high-fat diet-induced obesity in mice [25]. In contrast, intravenous administration of GIP to healthy lean men lowers resting energy expenditure (REE) [26]. In our previous study, we found that the dietary components that control GIP secretion, such as diacylglycerol [27], 1-monoolein [28], and RS4-type-resistant starch [29], increase postprandial fat utilization and prevent high-fat diet-induced obesity in mice.…”

Section: Introductionmentioning

confidence: 99%

Dietary steamed wheat bran increases postprandial fat oxidation in association with a reduced blood glucose-dependent insulinotropic polypeptide response in mice

Hosoda

Okahara

Mori

et al. 2017

Food & Nutrition Research

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Obesity is a global epidemic associated with a higher risk of cardiovascular disease and metabolic disorders, such as type 2 diabetes. Previous studies demonstrated that chronic feeding of steamed wheat bran (WB) decreases obesity. To clarify the underlying mechanism and the responsible component for the anti-obesity effects of steamed WB, we investigated the effects of dietary steamed WB and arabinoxylan on postprandial energy metabolism and blood variables. Overnight-fasted male C57BL/6J mice were fed an isocaloric diet with or without steamed WB (30%). Energy metabolism was evaluated using an indirect calorimeter, and plasma glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) levels were measured for 120 min after feeding. We similarly investigated the effect of arabinoxylan, a major component of steamed WB. Mice fed the WB diet had higher postprandial fat oxidation and a lower blood GIP response compared with mice fed the control diet. Mice fed the arabinoxylan diet exhibited a dose-dependent postprandial blood GIP response; increasing the arabinoxylan content in the diet led to a lower postprandial blood GIP response. The arabinoxylan-fed mice also had higher fat oxidation and energy expenditure compared with the control mice. In conclusion, the findings of the present study revealed that dietary steamed WB increases fat oxidation in mice. Increased fat oxidation may have a significant role in the anti-obesity effects of steamed WB. The postprandial effects of steamed WB are due to arabinoxylan, a major component of WB. The reduction of the postprandial blood GIP response may be responsible for the increase in postprandial fat utilization after feeding on a diet containing steamed WB and arabinoxylan.

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Effects of peripheral administration of synthetic human glucose‐dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes

Cited by 53 publications

References 32 publications

The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change

The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change

Effects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity

Dietary steamed wheat bran increases postprandial fat oxidation in association with a reduced blood glucose-dependent insulinotropic polypeptide response in mice

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