Effects of peritoneal injury and endotoxin on myoelectric activity and transit

Tanabe, Yoshitaka; Calland, J. Forrest; Schirmer, Bruce D.

doi:10.1016/j.jss.2003.08.234

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…For the first time, we now provide evidence that LPS reduces myenteric SA and that this effect is dose‐dependent. These observations are in agreement with findings from others who reported that LPS affects myoelectrical features in rats, sheep and pigs 31–33 where LPS reduces myoelectrical activity, though a dose dependency of these effects was not reported yet.…”

Section: Discussionsupporting

confidence: 93%

Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus

Chen

et al. 2010

Neurogastroenterology &Amp; Motility

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BACKGROUND Cannabinoid (CB) receptors are involved in the regulation of gastrointestinal (GI) motility under physiological and pathophysiological conditions. We aimed to characterize the possible influence of CB(1) and CB(2) receptors on motility impairment in a model of septic ileus. METHODS Lipopolysaccharide (LPS) injections were used to mimic pathophysiological features of septic ileus. Spontaneous jejunal myoelectrical activity was measured in rats in vivo, and upper GI transit was measured in vivo by gavaging of a charcoal marker into the stomach of mice, in absence or presence of LPS, and CB(1) and CB(2) receptor agonists and antagonists. Tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 levels were measured using enzyme-linked immunosorbent assay. Histology was performed with haematoxylin-eosin staining. KEY RESULTS Lipopolysaccharide treatment significantly reduced amplitude and frequency of myoelectric spiking activity and GI transit in vivo in a dose-dependent manner. TNF-alpha and IL-6 were increased in LPS-treated animals and histology showed oedema and cell infiltration. Both, the CB(1) agonist HU210 and the CB(2) agonist JWH133 reduced myoelectrical activity whereas the CB(1) antagonist AM251 caused an increase of myoelectrical activity. Pretreatment with AM251 or AM630 prevented against LPS-induced reduction of myoelectrical activity, and also against the delay of GI transit during septic ileus in vivo. CONCLUSIONS & INFERENCES The LPS model of septic ileus impairs jejunal myoelectrical activity and delays GI transit in vivo. Antagonists at the CB(1) receptor or the CB(2) receptor prevent the delay of GI transit and thus may be powerful tools in the future treatment of septic ileus.

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Section: Discussionsupporting

confidence: 93%

Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus

Chen

et al. 2010

Neurogastroenterology &Amp; Motility

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“…The IIP technique revealed a consistently close relationship between the bacteria and the neurons and muscle cells. Myoelectric patterns of intestinal motility induced by enteric bacteria or their toxins have been described in mammals (Husebye and others 2001, Tanabe and others 2004). These motility patterns are responsible for fluid propulsion in the intestine of animals infected by Escherichia coli , Vibrio cholerae , Salmonella Typhimurium or their toxins (Navarre and Roussel 1996).…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis of Aeromonas hydrophila strain KJ99 infection and its extracellular products in two species of fish

et al. 2009

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The distribution of antigen and pathological changes induced by an experimental infection with Aeromonas hydrophila strain KJ99, and its extracellular products, were studied in two species of fish. The microorganism was disseminated systemically and the haemodynamic and tissue changes were similar to those observed in septicaemia of mammals. Intussusception, degeneration and necrosis of the nervous plexus and muscular layers of the gastrointestinal tract were common findings.

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“…ondary DGE patients had weak gastric myoelectric activity, but at this time, it remains unclear if this was a precursor for their secondary abdominal process, given that there were other patients with weak activity but no ensuing abdominal processes. While there are not many studies on this matter, two animal studies have shown disruptions in small bowel myoelectrical activity following injury or infection of the peritoneum (9,22). However, whether there is a primary failure of initiation of myoelectric activity (primary DGE) versus some suppression of myoelectric activity (secondary DGE), the end result still translates to a decrease in signal measured by the patch and a predictive system to identify clinically relevant DGE.…”

Section: Discussionmentioning

confidence: 99%

Monitoring gastric myoelectric activity after pancreaticoduodenectomy for diet “readiness”

Dua

Navalgund

Axelrod

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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Postoperative delayed gastric emptying (DGE) is a frustrating complication of pancreaticoduodenectomy (PD). We studied whether monitoring of postoperative gastric motor activity using a novel wireless patch system can identify patients at risk for DGE. Patients ( n = 81) were prospectively studied since 2016; 75 patients total were analyzed for this study. After PD, battery-operated wireless patches (G-Tech Medical) that acquire gastrointestinal myoelectrical signals are placed on the abdomen and transmit data by Bluetooth. Patients were divided into early and late groups by diet tolerance of 7 days [enhanced recovery after surgery (ERAS) goal]. Subgroup analysis was done of patients included after ERAS initiation. The early and late groups had 50 and 25 patients, respectively, with a length of stay (LOS) of 7 and 11 days ( P < 0.05). Nasogastric insertion was required in 44% of the late group. Tolerance of food was noted by 6 versus 9 days in the early versus late group ( P < 0.05) with higher cumulative gastric myoelectrical activity. Diminished gastric myoelectrical activity accurately identified delayed tolerance to regular diet in a logistical regression analysis [area under the curve (AUC): 0.81; 95% confidence interval (CI), 0.74-0.92]. The gastric myoelectrical activity also identified a delayed LOS status with an AUC of 0.75 (95% CI, 0.67-0.88). This stomach signal continued to be predictive in 90% of the ERAS cohort, despite earlier oral intake. Measurement of gastric activity after PD can distinguish patients with shorter or longer times to diet. This noninvasive technology provides data to identify patients at risk for DGE and may guide the timing of oral intake by gastric "readiness." NEW & NOTEWORTHY Limited clinical indicators exist after pancreaticoduodenectomy to allow prediction of delayed gastric emptying (DGE). This study introduces a novel, noninvasive, wireless patch system capable of accurately monitoring gastric myoelectric activity after surgery. This system can differentiate patients with longer or shorter times to a regular diet as well as provide objective data to identify patients at risk for DGE. This technology has the potential to individualize feeding regimens based on gastric activity patterns to improve outcomes.

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Effects of peritoneal injury and endotoxin on myoelectric activity and transit

Cited by 6 publications

References 39 publications

Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus

Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus

Pathogenesis of Aeromonas hydrophila strain KJ99 infection and its extracellular products in two species of fish

Monitoring gastric myoelectric activity after pancreaticoduodenectomy for diet “readiness”

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