Effects of permethrin, cypermethrin and 3-phenoxybenzoic acid on rat sperm motility in vitro evaluated with computer-assisted sperm analysis

Yuan, Chen; Wang, Cheng; Gao, Shu‐Qin; Kong, Tian-Tian; Chen, Lei; Li, Xufeng; Lee, Song; Wang, Yubang

doi:10.1016/j.tiv.2009.11.001

Cited by 79 publications

(55 citation statements)

References 21 publications

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“…This is also the case of pyrethroids (Meeker et al, 2009), and this is also the reason for research on the molecular mechanisms of these compounds. Toxic effects of the pyrethroids cypermethrin, deltamethrin and fenvalerate were demonstrated not only on the nervous system (Wolansky and Harrill, 2008), but also on various types of mammalian somatic cells cultured in vitro (Prasanthi et al, 2005) and even on gametes -sperm (Yuan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Petr

Eva

Žalmanová

et al. 2013

Animal

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Pesticides can significantly harm reproduction in animals and people. Pyrethroids are often used as insecticides, and their toxicity for mammals is considered to be low. However, cypermethrin, deltamethrin and fenvalerate -as potent specific inhibitors of protein phosphatase calcineurin -can influence the meiosis of mammalian oocytes. The objective of this study was to evaluate the effects of these pyrethroids on the in vitro maturation of pig oocytes at different levels of meiotic competence. Under the tested concentrations, cypermethrin, deltamethrin and fenvalerate neither had a significant effect on the viability of oocytes nor did they induce significant degeneration of oocytes. However, these pyrethroids significantly affected meiotic maturation. The effects depended on the stage of meiotic competence of the oocytes. Maturation of growing pig oocytes with partial meiotic competence was induced. On the other hand, in fully grown pig oocytes with full meiotic competence, maturation in vitro was delayed. The specificity of these effects was further supported by the same effect of non-pyrethroidal inhibitors of calcineurin -cyclosporin A or hymenistatin I -on the maturation of oocytes with different levels of meiotic competence. However, pyrethroids, which do not inhibit calcineurin -allethrin or permethrin -had no effect on pig oocyte maturation. We demonstrated a significant effect of pyrethroids on the maturation of mammalian oocytes under in vitro conditions. This indicates that exposure to these substances could affect the fertility of people or animals.

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Section: Introductionmentioning

confidence: 99%

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Petr

Eva

Žalmanová

et al. 2013

Animal

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“…Treated groups revealed shrinkage of the seminiferous tubules, pyknosis in some basal spermatogonial cells, and reduction in the population of mature sperm thus widening of luminal diameter. Both Perry et al [25] and Yuan et al [26] have observed that increased exposure to permethrin and its metabolites result in lower sperm concentrations in mammals. Present findings are in consonance with, Issam and coworkers [27] who have described that permethrin treated groups have decreased the population of spermatocytes, spermatids and spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Bhardwaj

Sharma

2017

Int J Pharm Pharm Sci

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Objective: Protective effects of Tribulus terrestris (TT) and vitamin C were studied against permethrin induced changes in the histoarchitecture of goat testis.Methods: Hydroalcoholic extract of the fruits of Tribulus terrestris was prepared by maceration method and the extractive value was calculated. Fresh stock solution of permethrin (1mg/ml) in dimethyl sulphoxide and Tribulus terrestris (1mg/ml) in distilled water were prepared. Testicular tissues were cultured in TCM-199 nutrition media at 39℃ with 95% humidity and 5% CO₂ in the CO₂ incubator. Cultured testicular tissue was grouped as control having only the nutritive media, experimental group I(EI) received two doses of permethrin (100µg/ml and 200µg/ml), experimental group II(EII) was administered doses of permethrin along with vitamin C(0.1µM/ml) and experimental group III(EIII) was supplemented with doses of permethrin along with Tribulus terrestris (100µg/ml). All the groups were tested for 4 hr. and 8hr. for histoarcitectural studies.Results: Histological alterations were observed such as distorted shape of seminiferous tubules, decreased luminal and interstitial space, reduction in the population of spermatocytes, spermatozoa and spermatids in treated (E1) group as compared to control group. Maximum damage was detected at a higher dose of permethrin (200µg/ml) for 8h in contrast to lower doses (100 4h and 8h). Thus, it is concluded that permethrin has both dose and timedependent effects. Protective groups (E2 and E3) imparted ameliorative effects by reestablishing shape of seminiferous tubules, decreasing luminal and interstitial space, increased population of spermatocyte, spermatozoa, and spermatids as compared with treated groups (E1) Conclusion: It has been reported that permethrin affects male fertility by inducing detrimental changes in the structure and function of seminiferous tubules. Both vitamin C and TT have the ability to mitigate the effect of pesticide. TT shows aphrodisiac activity against permethrin induced alterations in goat testis.

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“…This oxidative damage may be related to a lipophilic characteristic of CP. However, a list of the adverse effects induced by CP includes mechanisms unidentified yet (YUAN et al, 2010).…”

Section: Spermatogenesis and Hormonal Controlmentioning

confidence: 99%

Cypermethrin exposure and effects on the reproductive male system: a literature review

2017

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The use of pesticides has become a major problem of public and environmental health in the world and especially in Brazil, which consumes tons of these compounds every year since the 50s. Among the pesticides, cypermethrin is an admittedly widely used synthetic pyrethroid due to its broad spectrum of action, resulting in its massive use in the agricultural sector. Epidemiological data show a considerable increase in the incidence of diseases in the male reproductive tract among them, the decline of sperm quality in various regions of the world, with consequent increase in demand for assisted reproduction services and increased incidences of cryptorchidism, hypospadias and testicular tumors. In recent years, researchers have shown that some pyrethroid compounds are capable of interfering with the endocrine system of animal species, including human being and therefore can be considered as endocrine disrupters. They can result in a deviation from normal homeostatic control or reproduction by interfering with the synthesis, secretion, transport, binding, action or elimination of natural hormones. It has been reported that endocrine disruptors may be responsible for the decline in sperm density and increase in hypospadias, cryptorchidism and testicular Revinter, v. 10, n. 03, p. 18-38, out. 2017. P á g i n a19 | 38 cancer in humans. In this sense, experimental studies have shown that cypermethrin acts indirectly on male gametogenesis, interfering with the synthesis of testosterone.Other disorders induced by cypermethrin are also reported, as structural changes of the seminiferous tubules, morphological changes in germ cells and sperm as well as a reduction in their count in semen. This paper aims to demonstrate aspects of endocrine disruption in the male reproductive system related to cypermethrin exposure, using data from animal studies (in vivo) and biological samples of human beings (in vitro). células germinativas e espermatozoides, bem como uma redução na sua contagem no sêmen. Este trabalho tem como objetivo demonstrar aspectos da desregulação endócrina no sistema reprodutor masculino relacionados à exposição à cipermetrina, utilizando dados de estudos animais (in vivo) e amostras biológicas de seres humanos (in vitro). Palavras

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Effects of permethrin, cypermethrin and 3-phenoxybenzoic acid on rat sperm motility in vitro evaluated with computer-assisted sperm analysis

Cited by 79 publications

References 21 publications

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Cypermethrin exposure and effects on the reproductive male system: a literature review

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