Effects of Permethrin or Deltamethrin Exposure in Adult Sprague Dawley Rats on Acoustic and Light Prepulse Inhibition of Acoustic or Tactile Startle

Regan, Samantha L.; Sugimoto, Chiho; Fritz, Adam; Vorhees, Charles V.

doi:10.1007/s12640-021-00339-9

Cited by 2 publications

(1 citation statement)

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“…Light prepulse inhibition of startle. On P68 rats were tested for ASR and TSR, using the same conditions as above, with two exceptions: 1) house lights were off and 2) before the acoustic or the tactile pulse there was a light (~1110 lux) prepulse presented at interstimulus intervals of 30, 70, 100, or 400 ms or no light before the pulse as described [30]. The light prepulse was from an LED array of high intensity lights (SDI) that provided approximately 1110 ± 17 lux (mean ± SEM) measured at the level of the animal holder with a light meter (Extech Easyview 33, Boston, MA).…”

Section: Behaviormentioning

confidence: 99%

Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model

et al. 2022

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Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates (~1 Gy/s), but further preclinical data are required to demonstrate this sparing effect. In this study, postnatal day 11 (P11) rats were treated with whole brain irradiation with protons at a total dose of 0, 5, or 8 Gy, comparing a conventional dose rate of 1 Gy/s vs. a FLASH dose rate of 100 Gy/s. Beginning on P64, rats were tested for locomotor activity, acoustic and tactile startle responses (ASR, TSR) with or without prepulses, novel object recognition (NOR; 4-object version), striatal dependent egocentric learning ([configuration A] Cincinnati water maze (CWM-A)), prefrontal dependent working memory (radial water maze (RWM)), hippocampal dependent spatial learning (Morris water maze (MWM)), amygdala dependent conditioned freezing, and the mirror image CWM [configuration B (CWM-B)]. All groups had deficits in the CWM-A procedure. Weight reductions, decreased center ambulation in the open-field, increased latency on day-1 of RWM, and deficits in CWM-B were observed in all irradiated groups, except the 5 Gy FLASH group. ASR and TSR were reduced in the 8 Gy FLASH group and day-2 latencies in the RWM were increased in the FLASH groups compared with controls. There were no effects on prepulse trials of ASR or TSR, NOR, MWM, or conditioned freezing. The results suggest striatal and prefrontal cortex are sensitive regions at P11 to proton irradiation, with reduced toxicity from FLASH at 5 Gy.

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Section: Behaviormentioning

confidence: 99%