1992
DOI: 10.1016/0190-9622(92)70060-s
|View full text |Cite
|
Sign up to set email alerts
|

Effects of petrolatum on stratum corneum structure and function

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

12
172
1
11

Year Published

1992
1992
2009
2009

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 296 publications
(196 citation statements)
references
References 19 publications
12
172
1
11
Order By: Relevance
“…Shave biopsies, obtained under local anesthesia, were taken from the normal appearing, non-sun-exposed, volar forearm or thigh skin of five of the aged (> 80 yr) and eight of the young (< 30 yr) human volunteers. Prior studies have shown that thigh and forearm display similar barrier repair kinetics (29). Samples were fixed in half-strength Karnovsky's fixative, divided, and processed routinely through either reduced 1.0% osmium tetroxide or 0.25% ruthenium tetroxide (30), followed by embeddment in an Epon-epoxy mixture (31).…”
Section: Functional Studiesmentioning
confidence: 99%
“…Shave biopsies, obtained under local anesthesia, were taken from the normal appearing, non-sun-exposed, volar forearm or thigh skin of five of the aged (> 80 yr) and eight of the young (< 30 yr) human volunteers. Prior studies have shown that thigh and forearm display similar barrier repair kinetics (29). Samples were fixed in half-strength Karnovsky's fixative, divided, and processed routinely through either reduced 1.0% osmium tetroxide or 0.25% ruthenium tetroxide (30), followed by embeddment in an Epon-epoxy mixture (31).…”
Section: Functional Studiesmentioning
confidence: 99%
“…Changes or defects in the lamellar body extrusion proces and formation of the lipid bilayers may lead to an alteration in the lipid bilayer organization, which is the case for skin diseases such as psoriasis, ichtyosis and eczema (Ghadially et al, 1992a) or atopic dermatitis (Linde, 1992;. It is very important for the treatment of such diseases to understand the processes leading to the disorganization.…”
Section: Introductionmentioning
confidence: 99%
“…Regular use of emollients and barrier creams has been shown to protect against drying and chemical irritation. 5,15 Simple petroleumbased emollients are generally as effective as emollients containing skin-related lipids, although several studies suggest that topical mixtures of key stratum corneum lipids, including ceramides, may accelerate barrier repair. 16,17 Adequate skin hydration is also extremely important for prevention in patients with chronic disease, even when symptoms are well controlled.…”
Section: Hydrationmentioning
confidence: 99%