Effects of PGE1 on the Function of Red Blood Cell.

Shigihara, Akira; Akama, Youichi; Tase, Choichiro; Okuaki, A

doi:10.2199/jjsca.13.42

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Erythrocytes can deform and pass through capillaries flexibly (erythrocyte deformability), which improves blood flow through good blood circulation and oxygen transportation ( Shigihara et al, 1993 ). Erythrocyte deformability is mainly dictated by three factors: geometric cell factors (surface area to volume ratio, morphological changes), internal cell viscosity, and cell membrane viscoelasticity ( Mohandas et al, 1993 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of clinical glycemic control markers treated with imeglimin and its effect on erythrocytes in patients with type 2 diabetes mellitus: study protocol of a single-arm, open-label, prospective, exploratory trial

et al. 2023

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Background: Imeglimin is a novel type 2 diabetes (T2D) drug that is expected to improve mitochondrial function. In its phase 3 clinical trials in Japanese patients with T2D, the hemoglobin A1c (HbA1c) decrease following imeglimin administration was slow, reaching a plateau after 20–24 weeks of treatment. In general, the erythrocyte lifespan may be a factor when HbA1c shows an abnormal value. Therefore, this study will comparatively evaluate HbA1c and other markers of glycemic control in patients with T2D after imeglimin administration and also examine the effects of imeglimin on erythrocytes.Methods: This single-arm, open-label, prospective, exploratory study is designed to evaluate the divergence between HbA1c and glycoalbumin (GA) or 1,5-anhydroglucitol (1,5-AG) and the glycemic reduction rate in 30 patients with T2D with inadequate glycemic control when imeglimin 2,000 mg is administered for 6 months. In addition, we will examine the effect on erythrocytes, the presumed cause of this divergence. We will measure sustained glycemic variability using flash glucose monitoring and examine the relationship between changes in these indices and HbA1c. Moreover, because prolonged erythrocyte lifespan is a possible cause of falsely high HbA1c levels, erythrocyte lifespan, erythrocyte deformability, and hemoglobin concentration will be evaluated as effects of imeglimin on erythrocytes. Furthermore, if imeglimin has an ameliorative effect on erythrocyte deformability, it may improve peripheral arterial disease; thus, we will also evaluate the toe-brachial pressure index, a measure of this effect.Discussion: In this study, if imeglimin administration results in diverging rates of hypoglycemic effect between HbA1c and GA or 1,5-AG and prolongs erythrocyte lifespan, GA and 1,5-AG, rather than HbA1c, will be considered appropriate measures of the hypoglycemic effect in the early stages of imeglimin administration. If imeglimin improves erythrocyte deformability, it may also be a new treatment strategy for peripheral arterial disease, a chronic complication of T2D.Ethics and dissemination: The study protocol was scientifically and ethically reviewed and approved by the Certified Clinical Research Review Board of Toho University (approval number: THU22002). The study protocol was registered in the Japan Registry of Clinical Trials (jRCT) in December 2022 (jRCTs031220489).

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Section: Discussionmentioning

confidence: 99%

Comparative evaluation of clinical glycemic control markers treated with imeglimin and its effect on erythrocytes in patients with type 2 diabetes mellitus: study protocol of a single-arm, open-label, prospective, exploratory trial

et al. 2023

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“…d -Sorbitol, a polylol derived from glucose by the enzyme aldose reductase, is a common organic solute in many cells of human body. , It can be used as a test substance for measuring liver plasma flow in humans and can be recommended as a cost-effective alternative to lactulose for the treatment of constipation in the elderly . As an important isomer, d -mannitol is also widely used in many fields of medicine because of its beneficial action on the brain, − kidneys, and heart, and hence research on its physiological functions in the human body is continuously done. , As we all know, the main solvent in the body fluid of humans and animals is water in which various ions coexist. Interactions of sorbitol/mannitol−sorbitol/mannitol, sorbitol/mannitol−water, and sorbitol/mannitol−ions must be in existence and bound up with the thermodynamic character of the systems.…”

Section: Introductionmentioning

confidence: 99%

“…4 As an important isomer, D-mannitol is also widely used in many fields of medicine because of its beneficial action on the brain, [5][6][7][8][9] kidneys, 10 and heart, 11 and hence research on its physiological functions in the human body is continuously done. 12,13 As we all know, the main solvent in the body fluid of humans and animals is water in which various ions coexist. Interactions of sorbitol/mannitol-sorbitol/mannitol, sorbitol/mannitol-water, and sorbitol/mannitol-ions must be in existence and bound up with the thermodynamic character of the systems.…”

Section: Introductionmentioning

confidence: 99%

Enthalpic Interaction of d-Sorbitol and d-Mannitol in Water and Aqueous Sodium Halide Solutions at 313.15 K

Song

Zhu

et al. 2005

J. Chem. Eng. Data

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The enthalpies of dilution of d-sorbitol and d-mannitol with water and aqueous sodium halide solutions were determined by isothermal microcalorimetry at 313.15 K. Experimental enthalpies of dilution varying with the concentration of the polylols were correlated with the virial expansion equation that was obtained with the McMillan−Mayer theory. Enthalpic interaction coefficients h 2, h 3, and h 4 in the equations have been determined, and the values of the pairwise enthalpic interaction coefficient (h 2) are discussed in terms of solute−solute and solute−solvent interactions.

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“…В лечении ОНМ большую роль играют диуретики. Из осмодиуретиков чаще всего применяют маннитол, глицерол, сорбитол, сорбилакт, реосорбилакт [5,8,14,15,16,18,26,27,29,30].…”

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Сlinico-morphological basing of prophilaxis and treatment of brain edema at intracranial extracerebral tumors

Chepkiy¹,

Шамаев²

2006

Ukr Neurosurg J

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Effects of PGE1 on the Function of Red Blood Cell.

Cited by 4 publications

References 8 publications

Comparative evaluation of clinical glycemic control markers treated with imeglimin and its effect on erythrocytes in patients with type 2 diabetes mellitus: study protocol of a single-arm, open-label, prospective, exploratory trial

Comparative evaluation of clinical glycemic control markers treated with imeglimin and its effect on erythrocytes in patients with type 2 diabetes mellitus: study protocol of a single-arm, open-label, prospective, exploratory trial

Enthalpic Interaction of d-Sorbitol and d-Mannitol in Water and Aqueous Sodium Halide Solutions at 313.15 K

Сlinico-morphological basing of prophilaxis and treatment of brain edema at intracranial extracerebral tumors

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