Effects of pH, Temperature and Ionic Strength on Aggregation Behavior of Dodecyldiethoxylamine Oxide

Abstract

The isoelectric point of dodecyldiethoxylamine oxide (DDEAO) containing hydroxyethyl groups was determined with the method of acid–base titration. The isoelectric point value of DDEAO is 7.8. The effects of pH, temperature and ionic strength on the aggregation behavior of DDEAO were investigated by surface tension measurements. The results show a good surface activity over a large pH range, especially under weakly acidic conditions. The surface activity of DDEAO increases trend increasing temperature. The thermodynamic parameters were also evaluated and the results show that the micelle formation is entropy‐driven within the temperature range investigated. CMC values decrease with increases in ionic strength. The packing parameters (P) were evaluated and ensure the formation of vesicles for DDEAO at various pH values, which is expected to have potential applications in some fields, such as in nanomaterials synthesis and the application in drug delivery.

A many-body dissipative particle dynamics parametrisation scheme to study behaviour at air–water interfaces

“…The surface tension at the CMC is experimentally reported as between 25–35 mN m −1 , 99–101 therefore our plateau to around ≈26 mN m −1 at higher concentrations is consistent with the available experimental data. There is a brief drop (to ≈19 mN m −1 ) in the surface tension before this plateau at high concentrations.…”

Nanoprecipitation of polymeric nanoparticle micelles based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl methacrylate (DPA), for intracellular delivery applications

“…The EtOH and MeOH based systems were reproducible in both PBS and McB (Fig. 3 ), with only a slight reduction in particle diameter for MeOH in PBS versus the McB, but solution ionic strength is reported to influence micelle aggregation number, critical micelle concentration (CMC), and size [ 40 , 41 ], however loading of the hydrophobic model compound OOT did not produce any discernable changes to the systems. Loading micelles with hydrophobic compounds can result in particle size changes [ 42 – 44 ] as has been seen in other MPC–DPA based micelle systems [ 24 ], however the previous micelle preparation method differed from that used for this study, which may account for apparent variance in particle size and stability.…”

Self-Assembly of Cyclodextrins and Their Complexes in Aqueous Solutions

“…Regarding external factors, increase of medium ionic strength will reduce solute hydration, decrease electrostatic repulsion, and increase counterion binding that ultimately will decrease the CMC. 19,24 Changing of ionic strength is more effective for ionic substances than nonionic ones. Influence of temperature on aggregation process is, however, not so ambiguous.…”